Paper Type |
Contributed Paper |
Title |
Formulation Development of Plai Nanoemulsion Based on the Influence of Surfactant Combinations |
Author |
Suvimol Surassmo*, Wanwisa Srinuanchai, Jakarwan Yostawonkul and Uracha Ruktanonchai |
Email |
suvimol@nanotec.or.th |
Abstract: Plai (Zinggiber cassumura Roxb.) nanoemulsions were prepared under oil-in-water (O/W) emulsion system by high pressure homogenization. This study investigated the effect of emulsifier complex on the appropriate compositions. The obtained formulation characterized in terms of droplet size, surface charge, storage stability and physical morphology were examined by visual observation and optical microscope. Uniform nanoemulsions can be achieved at appropriate concentration 5-6.5% (w/v) of surfactant and co-surfactant combinations. This optimized formulations demonstrated particle size less than 200 nm with the homogeneous distribution curve at 0.05-0.15 polydispersity index values and presented zeta potential in the range of -35.0 to -37.6 mV. For the stability of nanoemulsions were evaluated by storage at 25℃ (room temperature) and 45℃ (accelerated condition) for one month, the optimized nanoemulsions were maintained homogeneous emulsion when compared with other formulations. Furthermore, physical morphology photograph supported further results which their small droplet particles were observed. This research has an impact on the development of topical delivery system with the high oil loading in the composition. |
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Start & End Page |
994 - 999 |
Received Date |
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Revised Date |
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Accepted Date |
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Full Text |
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Keyword |
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Volume |
Vol.40 No.6 SPECIAL ISSUE 2 |
DOI |
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Citation |
Surassmo S., Srinuanchai W., Yostawonkul J. and Ruktanonchai U., Formulation Development of Plai Nanoemulsion Based on the Influence of Surfactant Combinations, Chiang Mai J. Sci., 2013; 40(6): 994-999. |
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