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Microwave Method for the Synthesis of Amantadine Hydrochloride
Paper Type  |
Contributed Paper |
Title |
Microwave Method for the Synthesis of Amantadine Hydrochloride |
Author |
Thinh Van Nguyen, Hien Van Pham, Duong Binh Vu, Anh Tuan Dang, Vu Khac Tran and Chau Dinh Phan |
Email |
vu.trankhac@hust.edu.vn; Chau.phandinh@hust.edu.vn |
|
Abstract: An easy and rapid method to prepare amantadine hydrochloride (1), which was used for the treatment of certain influenza infections type A and Parkinson’s disease was developed. In this work, we report a microwave method, which was effective in heating and saving solvents, for the synthesis of amantadine hydrochloride from adamantane by Ritter-type reaction via N-(1-adamantyl)acetamide in a two-step procedure with an improved overall yield 71%. The reaction conditions were investigated to increase the overall yield and to shorten the reaction time, reduce the use of toxic reagents, solvents, rendering it more effective and environment-friendly. |
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Start & End Page |
2454 - 2458 |
Received Date |
2017-08-26 |
Revised Date |
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Accepted Date |
2017-10-21 |
Full Text |
Download |
Keyword |
Amantadine hydrochloride, adamantane, acetonitrile, N-(1-adamantyl)acetamide, microwave radiation, Parkinson’s disease |
Volume |
Vol.45 No.6 (September 2018) |
DOI |
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Citation |
Nguyen T.V., Pham H.V., Vu D.B., Dang A.T., Tran V.K. and Phan C.D., Microwave Method for the Synthesis of Amantadine Hydrochloride, Chiang Mai Journal of Science, 2018; 45(6): 2454-2458. |
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