Submit your paper 
Download Template JOURNAL DETAIL
Development of a Stable Latanoprost Solution for Use as Eye Drops
Paper Type  |
Contributed Paper |
Title |
Development of a Stable Latanoprost Solution for Use as Eye Drops |
Author |
Somchai Sawatdee [a], Hirihattaya Phetmung [b] and Teerapol Srichana* [a,c] |
Email |
teerapol.s@psu.ac.th |
|
Abstract: The aim of this study was to develop latanoprost as a sterile eye drop solution using hydroxypropyl-β-cyclodextrin (HP-b-CD) as a solubilizing and stabilizing agent. Latanoprost eye drops were prepared according to the requirements for eye drop preparations. The inclusion complex of latanoprost/HP-β-CD was characterized by NMR spectroscopy. The efficacy of latanoprost eye drops prepared by using the complex with HP-b-CD was evaluated by measuring the intraocular pressure in a rabbit model. The stability of latanoprost eye drops was determined after storage at 5°C and 25°C/60%RH. The NMR results show that latanoprost was incorporated into the cavity of cyclodextrin. The dosage form of the new eye drop solution was stable at 25°C/60%RH for at least 6 months. The decrease of intraocular pressure observed was similar to that for XalatanÒ. |
|
Start & End Page |
656 - 668 |
Received Date |
2012-12-07 |
Revised Date |
|
Accepted Date |
2013-02-23 |
Full Text |
Download |
Keyword |
Latanoprost, Hydroxypropyl--cyclodextrin, Intraocular pressure reduction, Glaucoma |
Volume |
Vol.40 No.4 (OCTOBER 2013) |
DOI |
|
Citation |
[a] S.S., [b] H.P., [a T.S. and C] , Development of a Stable Latanoprost Solution for Use as Eye Drops, Chiang Mai Journal of Science, 2013; 40(4): 656-668. |
SDGs |
|
| View:616 Download:417 | |
RELATED ARTICLE
page: 631 - 642
Author:Jiradej Manosroi [a,b,c], Charinya Chankhampan [a], Kuncoro Foe [d], Maria Goretti Apriyani [d], Worapaka Manosroi [e] and Aranya Manosroi*[a,b,c]
Vol.43 No.3 (APRIL 2016) View: 642 Download:397
Copyrights © Since 2021 All Rights Reserved by Chiang Mai Journal of Science