Chiang Mai Journal of Science

The aim of this study was to develop latanoprost as a sterile eye drop solution using hydroxypropyl-β-cyclodextrin (HP-b-CD) as a solubilizing and stabilizing agent. Latanoprost eye drops were prepared according to the requirements for eye drop preparations. The inclusion complex of latanoprost/HP-β-CD was characterized by NMR spectroscopy. The efficacy of latanoprost eye drops prepared by using the complex with HP-b-CD was evaluated by measuring the intraocular pressure in a rabbit model. The stability of latanoprost eye drops was determined after storage at 5°C and 25°C/60%RH. The NMR results show that latanoprost was incorporated into the cavity of cyclodextrin. The dosage form of the new eye drop solution was stable at 25°C/60%RH for at least 6 months. The decrease of intraocular pressure observed was similar to that for Xalatan^Ò.