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Gelatin Microspheres Containing Multi-Walled Carbon Nanotubes: Preparation, Characterization, and Use as a Drug Carrier
Paper Type  |
Contributed Paper |
Title |
Gelatin Microspheres Containing Multi-Walled Carbon Nanotubes: Preparation, Characterization, and Use as a Drug Carrier |
Author |
Saowapa Thumsing [a,b] and Pitt Supaphol [a,b]* |
Email |
pitt.s@chula.ac.th |
|
Abstract: This work investigated how the incorporation of multi-walled carbon nanotubes (MWCNTs) into gelatin microspheres influences the effectiveness of microspheres as drug delivery systems by studying the adsorption of asiaticoside (AC) on the microspheres. We treated MWCNTs with a H2SO4/HNO3 solution. The treated MWCNTs were dispersed in deionized water and sonicated in an ultrasonic bath. The dispersion of treated MWCNTs was then mixed with the gelatin stock solution, and microsphere swelling and AC encapsulation efficiency were determined. Untreated gelatin microspheres were used for comparison. The experimental results indicated that the addition of the treated MWCNTs enhanced the mechanical stability of the gelatin microspheres. Furthermore, the addition of the treated MWCNTs to the gelatin microspheres increased AC encapsulation efficiency and slowed AC release. The maximum AC sorption capacities of the gelatin and the treated MWCNT-filled gelatin microspheres were 115.22 and 230.11 mg/g, respectively. In addition, cytotoxicity was investigated using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, which revealed that the treated MWCNT-filled gelatin microspheres did not affect murine fibroblast (L929) viability. Thus, the synthesized microspheres were biocompatible with the fibroblasts.
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Start & End Page |
1287 - 1300 |
Received Date |
2013-08-14 |
Revised Date |
|
Accepted Date |
2014-03-24 |
Full Text |
Download |
Keyword |
Carbon nanotubes, Gelatin, Asiaticoside, Microsphere, Controlled release |
Volume |
Vol.41 No.5/2 (OCTOBER 2014) |
DOI |
|
Citation |
[a S.T., B] , [a P.S. and B]* , Gelatin Microspheres Containing Multi-Walled Carbon Nanotubes: Preparation, Characterization, and Use as a Drug Carrier, Chiang Mai Journal of Science, 2014; 41(5/2): 1287-1300. |
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