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Polymer-Peptide Conjugate Hydrogels; Towards Controlled Drug Delivery
Paper Type  |
Contributed Paper |
Title |
Polymer-Peptide Conjugate Hydrogels; Towards Controlled Drug Delivery |
Author |
Arun A. Sohdi, Darren Campbell andPaul D. Topham* |
Email |
p.d.topham@aston.ac.uk |
|
Abstract: Peptide-based materials exhibit remarkable supramolecular self-assembling behavior, owing to their overwhelming propensity to from hierarchical structures from α-helices and β-sheets. Coupling a peptide sequence to a synthetic polymer chain allows greater control over the final physical properties of the supermolecular material. So-called ‘polymer-peptide conjugates’ can be used to create biocompatible hydrogels which are held together by reversible physical interactions. Potentially, the hydrogels can be loaded with aqueous-based drug molecules, which can be injected into targeted sites in the body if they can exhibit a gel-sol-gel transition under application and removal of a shear force. In this review, we introduce this topic to readers new to the field of polymer-peptide conjugates, discussing common synthetic strategies and their self-assembling behavior. The lack of examples of actual drug delivery applications from polymer-peptide conjugates is highlighted in an attempt to incite progress in this area. |
|
Start & End Page |
351 - 372 |
Received Date |
2012-03-16 |
Revised Date |
|
Accepted Date |
2012-04-21 |
Full Text |
Download |
Keyword |
polymer-peptide conjugates, hydrogels, drug delivery |
Volume |
Vol.39 No.3 (JULY 2012) |
DOI |
|
Citation |
Sohdi A.A. and Topham* D.C.A.D., Polymer-Peptide Conjugate Hydrogels; Towards Controlled Drug Delivery , Chiang Mai Journal of Science, 2012; 39(3): 351-372. |
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