Submit your paper 
Download Template JOURNAL DETAIL
A Smart Hydrogel-Based System for Controlled Drug Release
Paper Type  |
Contributed Paper |
Title |
A Smart Hydrogel-Based System for Controlled Drug Release |
Author |
Patchara Punyamoonwongsa * and Brian J. Tighe |
Email |
punyamop@aston.ac.uk |
|
Abstract: A method for the formation of polymer-lipid nanoparticles (Astosomes) is described. These lipid-based structures have been shown to be capable of being loaded with hydrophobic compounds. A range of dyes (oil red O, rhodamine B, basic fuchsin and fluorescein sodium salt) differing in structure were used as surrogate compounds for drugs in order to characterize the factors that affect incorporation and release. The incorporation methodology allowed each of these compounds, which were widely different in chemical structure, to be incorporated into the polymer-lipid complexes prior to polymerization with hydrogel-forming monomers. The surface behaviour of the complexes under compression, measured using a Langmuir trough, proved to be a useful method of characterizing them in both non-loaded and loaded forms. These loaded polymer-lipid nanoparticles were then encapsulated into hydrogels to give optically clear hydrophilic polymer matrices. Poly(hydroxyethyl methacrylate-co-methacrylic acid), poly(HEMA-co-MAA), hydrogel matrixes were prepared by the redox polymerization of HEMA and MAA monomers using ethylene glycol dimethacrylate as cross-linking agent and Oxone and ascorbic acid as initiators. The release studies of model drugs delivered from hydrogels were carried out in phosphate buffers of pH 7.4 and pH 9.2 and were determined by fluorimetry. The extents of release were dependent on the partition coefficients and the ionization of the drugs, the release medium and the degree of hydrogel swelling. Results indicate that the loaded hydrogels can deliver model drugs at a slow rate for a long period and offer a useful technology for the development of therapeutic contact lenses with long-term controlled drug release characteristics. This would be of particular value in the case of the new generation of lenses which can be worn continuously for 30 consecutive day and night period.
|
|
Start & End Page |
471 - 478 |
Received Date |
|
Revised Date |
|
Accepted Date |
|
Full Text |
Download |
Keyword |
Astosomes, drug delivery, Langmuir monolayer, phospholipids, hydrogel |
Volume |
Vol.32 No.3 (SEPTEMBER 2005) |
DOI |
|
Citation |
* P.P. and Tighe B..J.., A Smart Hydrogel-Based System for Controlled Drug Release, Chiang Mai Journal of Science, 2005; 32(3): 471-478. |
SDGs |
|
| View:656 Download:204 | |
RELATED ARTICLE
Optimization of Chitosan-Alginate Hydrogel Properties for Controlled Release of Urea
Article ID: e2025008
Author:Melody Kimi and Chee Jiun Chong
Vol.52 No.1 (January 2025) View: 246 Download:106
Article ID: e2025008
Author:Melody Kimi and Chee Jiun Chong
Vol.52 No.1 (January 2025) View: 246 Download:106
Clindamycin Hydrochloride-loaded Composite Hydrogel of Poly((ethylene glycol) dimethacrylate-glycidyl methacrylate) and Mesoporous Silica Nanoparticles for Bacterial Infection Treatment
page: 765 - 775
Author:Piyarat Sungkhaphan, Boonlom Thavornyutikarn, Pakkanun Kaewkong, Weerachai Singhatanadgit, Soraya Pornsuwan and Wanida Janvikul*
Vol.47 No.4 (Special Issue II : July 2020) View: 846 Download:662
page: 765 - 775
Author:Piyarat Sungkhaphan, Boonlom Thavornyutikarn, Pakkanun Kaewkong, Weerachai Singhatanadgit, Soraya Pornsuwan and Wanida Janvikul*
Vol.47 No.4 (Special Issue II : July 2020) View: 846 Download:662
Molecular Aggregation of Four Modified Xyloglucan Models in Aqueous Solution
page: 2201 - 2210
Author:Napat Kongtaworn, Namon Hirun, Vimon Tantishaiyakul, Thanyada Rungrotmongkol and Supaporn Dokmaisrijan
Vol.45 No.5 (Special 2018) View: 774 Download:237
page: 2201 - 2210
Author:Napat Kongtaworn, Namon Hirun, Vimon Tantishaiyakul, Thanyada Rungrotmongkol and Supaporn Dokmaisrijan
Vol.45 No.5 (Special 2018) View: 774 Download:237
Kinetic Study of Ibuprofen Release from a pH- and Temperature-sensitive Hydrogel, Based on Poly(styrene-alt-maleic anhydride) Copolymer
page: 224 - 236
Author:Morteza Bahram, Fariba Hoseinpour, Naimeh Mohseni and Peyman Najafi-Moghaddam
Vol.44 No.1 (JANUARY 2017) View: 670 Download:468
page: 224 - 236
Author:Morteza Bahram, Fariba Hoseinpour, Naimeh Mohseni and Peyman Najafi-Moghaddam
Vol.44 No.1 (JANUARY 2017) View: 670 Download:468
Polymer-Peptide Conjugate Hydrogels; Towards Controlled Drug Delivery
page: 351 - 372
Author:Arun A. Sohdi, Darren Campbell andPaul D. Topham*
Vol.39 No.3 (JULY 2012) View: 634 Download:259
page: 351 - 372
Author:Arun A. Sohdi, Darren Campbell andPaul D. Topham*
Vol.39 No.3 (JULY 2012) View: 634 Download:259
Design and Preparation of AMPS-Based Hydrogels
for Biomedical Use as Wound Dressings
page: 183 - 189
Author:Kanarat Nalampang, Nantarat Suebsanit, Chinanat Witthayaprapakorn, and Robert Molloy
Vol.34 No.2 (MAY 2007) View: 717 Download:233
page: 183 - 189
Author:Kanarat Nalampang, Nantarat Suebsanit, Chinanat Witthayaprapakorn, and Robert Molloy
Vol.34 No.2 (MAY 2007) View: 717 Download:233
Synthesis and Characterisation of Poly(2-hydroxyethyl methacrylate-co-methyl acrylate) Hydrogels for Use as Temporary Skin Substitutes
page: 71 - 82
Author:Tiwaporn Siriwittayakorn [a], Nantarat Suebsanit [a], Robert Molloy [a], Paisit Siriwittayakorn [b] and Malinee Prasitsilp [c]
Vol.28 No.2 (DECEMBER 2001) View: 677 Download:225
page: 71 - 82
Author:Tiwaporn Siriwittayakorn [a], Nantarat Suebsanit [a], Robert Molloy [a], Paisit Siriwittayakorn [b] and Malinee Prasitsilp [c]
Vol.28 No.2 (DECEMBER 2001) View: 677 Download:225
Copyrights © Since 2021 All Rights Reserved by Chiang Mai Journal of Science