Chiang Mai Journal of Science

Print ISSN: 0125-2526 | eISSN : 2465-3845

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Essential Oil of Solanum spirale Fruits and Its Biological Activities

Sukanya Keawsa-ard [a], Boonsom Liawruangrath* [b], Saisunee Liawruangrath [c], Aphiwat Teerawutgulrag [c] Stephen G. Pyne [d]
* Author for corresponding; e-mail address: liawruangrath@gmail.com
Volume: Vol.43 No.3 (APRIL 2016)
Research Article
DOI:
Received: 6 August 2014, Revised: -, Accepted: 28 October 2014, Published: -

Citation: Keawsa-ard S., Liawruangrath B., Liawruangrath S. and Pyne A.T..S.G., Essential Oil of Solanum spirale Fruits and Its Biological Activities, Chiang Mai Journal of Science, 2016; 43(3): 547-555.

Abstract

 The essential oil of Solanum spirale Roxb. unripe fruits was analyzed for the first time using GC-MS. Twenty-nine constituents were identified, constituting 82.11% of the total chromatographical oil components. The major components were n-hexadecanoic acid (56.01%), linolelic acid (9.71%), octadecanoic acid (4.41%), methyl plamitate (1.69%), tetradecanoic acid (1.55%), (E)-phytol (1.18%), n-hexanal (0.91%), methyl salicylate (0.83%), 4-hydroxy-4-methylpentan-2-one (0.81%), pentadecanoic acid (0.71%) and b-selinene (0.56%). The oil exhibited anticancer activities against MCF-7 (breast cancer) and NCI-H187 (small cell lung cancer) with the IC50 values of 23.17 and 49.07 µg/mL, respectively. It exhibited antituberculosis activity against Mycobacterium tuberculosis H37Ra with the MIC value of 50.0 µg/mL and it also showed moderately antibacterial activity against Escherichia coli and Staphylococcus aureus with the MIC values of 118 mg/mL.

Keywords: Solanum spirale, unripe fruits, essential oil, anticancer activity, cytotoxic activity, antituberculosis activity, antibacterial activity

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