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Cytotoxicity of Aromatic Substituted Curcuminoid against Human Lung Cancer Cell Line


Paper Type 
Contributed Paper
Title 
Cytotoxicity of Aromatic Substituted Curcuminoid against Human Lung Cancer Cell Line
Author 
Hien Van Nguyen, Van Thi Bich Pham and Hao Minh Hoang
Email 
haohm@hcmute.edu.vn
Abstract:

We now focus on the synthesis of curcumin analogues (1-8) bearing -OCH3/-OH/-F substituents on the phenyl rings via base-catalyzed aldol condensations between various benzaldehydes with pentane- 2,4-dione. The analogues were subsequently tested for in vitro anticancer capacity against human lung cancer cell line (LU-1) by determining their half-maximal inhibitory concentration (IC50, μM). The presence of methoxy/hydroxy groups at meta-positions in aromatic rings of compounds (3, IC50 = 29.21±2.12 μM; 5, IC50 = 68.69±5.47 μM) exhibited higher anticancer activities, whereas analogues (2, 4) having similar substituents at para-positions displayed very poor activities when compared with curcumin (1, IC50 = 72.88±6.19 μM). Fluorinated curcuminoids (6, 7) showed inactivities. Remarkably, the level of inhibition of (8) containing 3-fluoro aromatic moiety was improved with an IC50 of 56.39±4.26 μM in this assay. The results indicated that the 3-substituted phenyl motifs are responsible for inhibition of LU-1 cell growth.

Start & End Page 
1313 - 1321
Received Date 
2021-02-04
Revised Date 
2021-03-20
Accepted Date 
2021-03-25
Full Text 
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Correspondence & Author Name 
Keyword 
Curcuminoid, human lung cancer cell line, anticancer activity, aldol condensation, aromatic substitution
Volume 
Vol.48 No.5 (September 2021)
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