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Synthesis of 6/8-Methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes: A Facile CTAB Catalyzed Protocol
Paper Type  |
Contributed Paper |
Title |
Synthesis of 6/8-Methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes: A Facile CTAB Catalyzed Protocol |
Author |
Rubina Munir, Muhammad Makshoof Atha, Muhammad Zia-ur-Rehman and Noman Javid |
Email |
organist94@gmail.com |
|
Abstract: An efficient method for nucleophilic aromatic substitution of 2-chloroquinoline-3-carbaldehydes
is described for the synthesis of 6/8-methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes. The protocol
involves the effective use of phase transfer catalyst CTAB in combination with polyethyleneglycol-400
to obtain the desired products in less reaction time. The newly developed method is found superior
to the previously reported methods due to easy work up and excellent yields. |
|
Start & End Page |
175 - 180 |
Received Date |
2019-07-23 |
Revised Date |
|
Accepted Date |
2019-09-20 |
Full Text |
Download |
Keyword |
quinoline, nucleophilic aromatic substitution, phase transfer catalyst, CTAB, piperidine |
Volume |
Vol.47 No.1 (January 2020) |
DOI |
|
Citation |
Munir R., Atha M.M., Zia-ur-Rehman M. and Javid N., Synthesis of 6/8-Methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes: A Facile CTAB Catalyzed Protocol, Chiang Mai Journal of Science, 2020; 47(1): 175-180. |
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