Chiang Mai Journal of Science

Synthesis of 6/8-Methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes: A Facile CTAB Catalyzed Protocol

Paper Type	Contributed Paper
Title	Synthesis of 6/8-Methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes: A Facile CTAB Catalyzed Protocol
Author	Rubina Munir, Muhammad Makshoof Atha, Muhammad Zia-ur-Rehman and Noman Javid
Email	organist94@gmail.com
Abstract:  An efficient method for nucleophilic aromatic substitution of 2-chloroquinoline-3-carbaldehydes is described for the synthesis of 6/8-methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes. The protocol involves the effective use of phase transfer catalyst CTAB in combination with polyethyleneglycol-400 to obtain the desired products in less reaction time. The newly developed method is found superior to the previously reported methods due to easy work up and excellent yields.
Start & End Page	175 - 180
Received Date	2019-07-23
Revised Date
Accepted Date	2019-09-20
Full Text	Download
Keyword	quinoline, nucleophilic aromatic substitution, phase transfer catalyst, CTAB, piperidine
Volume	Vol.47 No.1 (January 2020)
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