Synthesis of 6/8-Methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes: A Facile CTAB Catalyzed Protocol
Rubina Munir, Muhammad Makshoof Atha, Muhammad Zia-ur-Rehman and Noman Javid* Author for corresponding; e-mail address: organist94@gmail.com
Volume: Vol.47 No.1 (January 2020)
Research Article
DOI:
Received: 23 July 2019, Revised: -, Accepted: 20 September 2019, Published: -
Citation: Munir R., Atha M.M., Zia-ur-rehman M. and Javid N., Synthesis of 6/8-Methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes: A Facile CTAB Catalyzed Protocol, Chiang Mai Journal of Science, 2020; 47(1): 175-180.
Abstract
An efficient method for nucleophilic aromatic substitution of 2-chloroquinoline-3-carbaldehydes is described for the synthesis of 6/8-methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes. The protocol involves the effective use of phase transfer catalyst CTAB in combination with polyethyleneglycol-400 to obtain the desired products in less reaction time. The newly developed method is found superior to the previously reported methods due to easy work up and excellent yields.