Antibacterial Activity Against Acne Involved Bacteria of Chitosan in a Soluble State and as Nanoparticles

Supreedee Sungkharak [a; b]; Nicha Supasit [b]; Sasiluk Choopan [b]; Suwipa Ungphaiboon[a; b]

Antibacterial Activity Against Acne Involved Bacteria of Chitosan in a Soluble State and as Nanoparticles

Supreedee Sungkharak [a, b], Nicha Supasit [b], Sasiluk Choopan [b] and Suwipa Ungphaiboon*[a, b]
* Author for corresponding; e-mail address: suwipa.u@psu.ac.th
Volume: Vol.43 No.5 (OCTOBER 2016)
Research Article
DOI:
Received: 16 March 2015, Revised: -, Accepted: 27 May 2015, Published: -

Citation: [a S.S., B] , Supasit N., Choopan S. and B] S.U., Antibacterial Activity Against Acne Involved Bacteria of Chitosan in a Soluble State and as Nanoparticles, Chiang Mai Journal of Science, 2016; 43(5): 1149-1158.

Abstract

Chitosans with different molecular weights (MW) in the range of 10 kDa -500 kDa from two sources in a soluble state and as chitosan nanoparticles were investigated for their antibacterial activities against three bacteria involved in acne namely Propionibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis. Chitosans in a soluble state showed antibacterial effects with the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values ranged from 15 to 125 mg/mL. The antibacterial activities were dependent on the MW, the sources of the chitosan and the type of bacteria. The antibacterial activity was enhanced as the MW increased. In addition, the sources of chitosan had a marked influence on the antibacterial activity against P. acnes and S. epidermidis. Chitosan nanoparticles exhibited higher antibacterial activity than the solution form. The MIC and MBC values ranged from 0.25 to 31 mg/mL depending on their particle size in that small chitosan nanoparticles (<200 nm) had higher antibacterial activity than larger chitosan nanoparticles (>200 nm). Chitosan in both a soluble form and nanoparticles has potential to use as an anti-acne agent due to their antibacterial properties.

Keywords: chitosan, soluble state, nanoparticle, anti-acne agent, antibacterial activity, molecular weight

Antibacterial Activity and Photocatalytic Performance of Zinc Oxide Nanoparticles from Morus alba L.
DOI: 10.12982/CMJS.2026.009.

Natrada Phumprakhon, Mongkol Nontakitticharoen, Angkhana Chuajedton, Sirinuch Loiha, Ratchaneekorn Pilasombat, Prawit Nuengmatcha, Surapon Saensouk and Siripit Pitchuanchom*

Vol.53 No.1 (January 2026)
Research Article View: 897 Download: 94

Enhancement of Antioxidant Activity and Inhibition of Polyphenol Oxidase from Green Oak Lettuce by Chitosan-Encapsulated Rambutan (Nephelium lappaceum L.) Peel Extract
DOI: 10.12982/CMJS.2025.035.

Panita Kongsune, Kittisak Sangthongchin, Phasin Ampha, Manee Maneechote and Netnapa Chana

Vol.52 No.4 (July 2025)
Research Article View: 2,117 Download: 585

Optimization of Chitosan-Alginate Hydrogel Properties for Controlled Release of Urea
DOI: 10.12982/CMJS.2025.008.

Melody Kimi and Chee Jiun Chong

Vol.52 No.1 (January 2025)
Research Article View: 1,407 Download: 1,702

Antibacterial Properties of Bacillus sp. TBRC 16324 and Its Efficacy in Controlling Bacterial Leaf Blight Disease in Rice
DOI: 10.12982/CMJS.2024.100.

Juangjun Jumpathong, Chanetsada Yothasuphap, Paweena Permthawee, Bernard Dell, Nungruthai Suphrom, Thanita Boonsrangsom and Tepsuda Rungrat

Vol.51 No.6 (November 2024)
Research Article View: 1,957 Download: 489

Increased Antibacterial Activity of Zinc-Silver Doped Hydroxyapatite Synthesized via Ultrasonic in Combination with Sol-Gel Technique using Glutinous Rice as a Template
DOI: 10.12982/CMJS.2024.044.

Piaw Phatai, Sirilak Kamonwannasit, Sakuntala Siri-udom, Cybelle Morales Futalan, Pongtanawat Khemthong, Saran Youngjan, Teera Butburee, Khongvit Prasitnok and Orrasa Prasitnok

Vol.51 No.3 (May 2024)
Research Article View: 1,326 Download: 607

Efficacy of Dried Indian Gooseberry Kombucha on a Pre–industrial Scale: Chemical Composition, Antioxidant and Antibacterial Activity
DOI: 10.12982/CMJS.2023.034.

Tharinee Klawpiyapamornkun, Thida Kaewkod, Toungporn Uttarotai, Sunanta Wangkarn, Panee Sirisa-ard, Suwalee Kiatkarun, Yingmanee Tragoolpua and Sakunnee Bovonsombut

Vol.50 No.3 (May 2023)
Research Article View: 1,781 Download: 835

Cu2O(ClO4)2/TiO2 Dandelion-shaped Nanospheres with Photocatalytic Antibacterial Activity
DOI: 10.12982/CMJS.2022.021.

Xiaolin Xu, Yacong Yang, Yingchun Miao, Kaiquan Liu, Yuqin Chen and Shaoyan Yue

Vol.49 No.2 (March 2022)
Research Article View: 2,203 Download: 444

Bacterial Cellulose and Bacterial Cellulose/Chitosan Films Containing Mangosteen Pericarp Extract for Wound Dressings
page: 952 - 968

Pronpatsorn Moonsungnoen, Duangjai Ochaikul and Pathavuth Monvisade

Vol.48 No.4 (July 2021)
Research Article View: 2,225 Download: 705

Optimal Conditions for Lignin Coagulation in Lignin Contaminated Water
page: 123 - 131

Surin Saipanya*, Ruangsri Watanesk, Wimol Saiyasombat and Sunanta Wangkarn

Vol.30 No.2 (AUGUST 2003)
Research Article View: 1,130 Download: 333

Application of Silver Nanoparticles Synthesized by Using Ipomoea batatas L. Waste to Improve Antibacterial Properties and Hydrophobicity of Polyester Cloths
page: 2715 - 2729

Eli Rohaeti and Anna Rakhmawati

Vol.45 NO.7 (November 2018)
Research Article View: 1,322 Download: 591

Pencil Graphite Based Biosensor for Rapid Malathion Pesticide Detection
page: 2374 - 2380

Lerdluck Kaewvimol

Vol.45 No.6 (September 2018)
Research Article View: 1,198 Download: 386

Comparative GC-MS Analysis, In-vitro Antioxidant and Antimicrobial Activities of the Essential Oils Isolated from the Peel of Omani Lime
page: 1782 - 1795

Amwaj Mohammed Al-Breiki, Huda Mubarak Al-Brashdi, Jamal Nasser Al-Sabahi and Shah Alam Khan

Vol.45 No.4 (July 2018)
Research Article View: 1,612 Download: 373

Antibacterial, Antioxidant Properties and Bioactive Compounds of Thai Cultivated Mushroom Extracts Against Food-borne Bacterial Strains
page: 1713 - 1727

Mathurot Chaiharn, Waya S. Phutdhawong, Doungporn Amornlerdpison and Weerachai Phutdhawong

Vol.45 No.4 (July 2018)
Research Article View: 1,480 Download: 552

Phytochemical Screening and Antibacterial Activities of Tuber Extract of Stephania pierrei Diels
page: 1396 - 1406

Sirilak Kamonwannasit and Agarat Kamcharoen*

Vol.45 No.3 (May 2018)
Research Article View: 1,362 Download: 470

Antibacterial and Antioxidant Activities of 3-O-methyl Ellagic Acid from Stem Bark of Polyalthia longifolia Thw.
page: 858 - 867

Pankaj Kumar Jain, Arjun Patra*+, Swaha Satpathy, Sonika Jain and Saleemulla Khan

Vol.45 No.2 (March 2018)
Research Article View: 1,291 Download: 369

Antimicrobial Efficacy of a Combination of Crocodile (Crocodylus siamensis) Leukocyte Extract and Hen Egg Lysozyme
page: 797 - 810

Tinnakorn Theansungnoen, Patthana Tastub, Nisachon Jangpromma, Nualyai Yaraksa, Theeranan Temsiripong and Sompong Klaynongsruang*

Vol.45 No.2 (March 2018)
Research Article View: 1,158 Download: 319

Scaffolds of Fish Skin Gelatin from Unicorn Leatherjackets (Aluterus monoceros) Reinforced with Chitosan for Bone Tissue Engineering
page: 1611 - 1623

Safiah Saah, Kwunchit Oungbho* and Soottawat Benjakul

Vol.44 No.4 (October 2017)
Research Article View: 1,226 Download: 405

Newer 1,2,3-oxathiazino [5,6-c] Quinolin-5 (6H) One-2,2-dioxidederivatives: Synthesis, Molecular Properties Prediction and Biological Evaluation as Potent Antibacterial, Anticoagulant Agents
page: 1463 - 1474

Naveen Polkam, Parsharamulu Rayam, Tejeswara Rao Allaka, Shankaraiah Malthum, Naveen Kuntala, Bhaska

Vol.44 No.4 (October 2017)
Research Article View: 1,228 Download: 273

Production of Chitooligosaccharides with Antibacterial Potential via Crude Chitinase Enzymes from Marine Fungi
page: 1224 - 1230

Apiradee Pilantanapak*, Yaowapha Waiprib, Phattharawadee Eadtem and Watanalai Panbangred

Vol.44 No.4 (October 2017)
Research Article View: 1,205 Download: 323

Antibiotics Constituents of Endophytic Bacillus amyloliquefaciens UD25 Extracted from a Medicinal Plant, Memecylon edule Roxb.
page: 788 - 799

Artidtaya Bhoonobtong, Sirirath Sodngam, Sophon Boonlue, Wandee Bunyatratchata and Wiyada Mongkolt

Vol.44 No.3 (July 2017)
Research Article View: 2,394 Download: 1,051

Effects of Chitosan and Salicylic Acid on Stemona Alkaloid Production in Hydroponic Culture of Stemona curtisii Hook. f.
page: 1070 - 1076

Jiraporn Palee [a], Srisulak Dheeranupattana* [b], Sunanta Wangkarn [c], Stephen G. Pyne [d] and Alison T. Ung [e]

Vol.43 No.5 (OCTOBER 2016)
Research Article View: 1,181 Download: 348

Encapsulation of Artocarpus lacucha Roxb. Extract in Alginate Chitosan Nanoparticles for Inhibition of Methicillin Resistant Staphylococcus aureus and Bacteria Causing Skin Diseases
page: 946 - 958

Thida Kaewkod [a], Khajornsak Tragoolpua [b] and Yingmanee Tragoolpua* [a]

Vol.43 No.5 (OCTOBER 2016)
Research Article View: 1,165 Download: 410

Essential Oil of Solanum spirale Fruits and Its Biological Activities
page: 547 - 555

Sukanya Keawsa-ard [a], Boonsom Liawruangrath* [b], Saisunee Liawruangrath [c], Aphiwat Teerawutgulrag [c] Stephen G. Pyne [d]

Vol.43 No.3 (APRIL 2016)
Research Article View: 1,766 Download: 381

Analysis of Chitin, Chitosan, and Optimization for Carotenoids Extraction Yield with Rice Bran Oil from Thai Fairy Shrimp
page: 918 - 929

Tanyarat Poothawan and Khomsorn Lomthaisong

Vol.42 No.4 (OCTOBER 2015)
Research Article View: 1,178 Download: 418

Emulsions stabilized by chitosan/lithium dodecyl sulfate complexes
page: 393 - 400

Thammasit Vongsetskul, Kewalin Phaenthong, Ratana Chanthateyanonth, Panya Sunintaboon and Pramuan T

Vol.42 No.2 (APRIL 2015)
Research Article View: 11,528 Download: 498

Production and Immobilization of Levansucrase
page: 44 - 51

Surawut Sangmanee, Santhana Nakapong, Kamontip Kuttiyawong and Rath Pichyangkura

Vol.42 No.1 (JANUARY 2015)
Research Article View: 1,129 Download: 327

Antimicrobial and antioxidant activity of various solvent extracts of Salsola stenoptera Wagenitz and Petrosimonia nigdeensis Aellen (Chenopodiaceae) plants
page: 156 - 172

Meltem Asan Ozusaglam, Mahmut Erzengin, Derya Onal Darilmaz, Seher Karaman Erkul, Mehtap Tekse

Vol.42 No.1 (JANUARY 2015)
Research Article View: 1,416 Download: 253

Antibacterial Activity and Chemical Composition of Essential Oil and Various Extracts of Fagraea fragrans Roxb. Flowers
page: 214 - 223

Patcharee Pripdeevech* [a] and Jarupux Saansoomchai [b]

Vol.40 No.2 (APRIL 2013)
Research Article View: 1,412 Download: 551

Antioxidant, Antibacterial, Anticancer Activities and Chemical Constituents of the Essential Oil from Mesua ferrea Leaves
page: 455 - 463

Sukanya Keawsa-ard* [a] and Samart Kongtaweelert [b]

Vol.39 No.3 (JULY 2012)
Research Article View: 1,432 Download: 634

Anticancer and Antibacterial Activities of the Isolated Compounds from Solanum spirale Roxb. Leaves
page: 445 - 454

Sukanya Keawsa-ard [a], Surapol Natakankitkul [a], Saisunee Liawruangrath [b], Aphiwat Teerawutgulra

Vol.39 No.3 (JULY 2012)
Research Article View: 1,258 Download: 427

Effect of Relative Humidity on MechanicalProperties of Blended Chitosan-Methylcellulose Film
page: 133 - 137

Pornchai Rachtanapun and Panchat Wongchaiya

Vol.39 No.1 (JANUARY 2012)
Short Communication View: 1,163 Download: 203

Antibacterial Activity of Bauhinia acuminata L. Seed Protein Extract with Low Hemolytic Activity Against Human Erythrocytes
page: 242 - 251

Karaket Phansri [a], Rakrudee Sarnthima [a], Sompong Thammasirirak [b], Pasakorn Boonchalee [c] and

Vol.38 No.2 (APRIL 2011)
Research Article View: 1,334 Download: 285

Effect of Chitosan and Mordants on Dyeability of Cotton Fabrics with Ruellia tuberosa Linn.
page: 95 - 104

Piyaporn Kampeerapappun, Trongsu Phattararittigul, Sutida Jittrong and Dararat Kullachod

Vol.38 No.1 (JANUARY 2011)
Research Article View: 1,291 Download: 296

Comparison of Sludge Granule and UASB Performance by Adding Chitosan in Different Forms
page: 95 - 102

Boonyarit Nuntakumjorn, Wuthichok Khumsalud, Naret Vetsavas, Thoranin Sujjaviriyasup and Chantarapor

Vol.35 No.1 (JANUARY 2008)
Research Article View: 1,155 Download: 371

Artificial Tear Formulation from Chitosan
page: 501 - 505

Phuriwat L eesawat *[a], K arn V earnsilp[a], Nijaporn Y anasarn [a] and Peeracha Thanawatta

Vol.32 No.3 (SEPTEMBER 2005)
Research Article View: 1,105 Download: 366

Chiang Mai Journal of Science

2,458

Q3 1.0

Q2 1.6

7 days

Outline

Figures and Tables