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Antibiotics Constituents of Endophytic Bacillus amyloliquefaciens UD25 Extracted from a Medicinal Plant, Memecylon edule Roxb.


Paper Type 
Contributed Paper
Title 
Antibiotics Constituents of Endophytic Bacillus amyloliquefaciens UD25 Extracted from a Medicinal Plant, Memecylon edule Roxb.
Author 
Artidtaya Bhoonobtong, Sirirath Sodngam, Sophon Boonlue, Wandee Bunyatratchata and Wiyada Mongkolt
Email 
wiymon@kku.ac.th
Abstract:
Natural products derived from endophytic microorganisms are one possible source for a new array of drug candidates. In this study, an endophytic Bacillus amyloliquefaciens UD25 was isolated and identified from a medicinal plant (Memecylon edule Roxb). Crude ethyl acetate extract of a whole culture of B. amyloliquefaciens UD25 demonstrated growth inhibition of pathogenic bacteria, including Streptococcus sp., methicillin resistant Staphylococcus aureus (MRSA), Enterococcus faecalis, Bacillus cereus and Escherichia coli. The antibiotic compounds were analyzed by GC-MS. Eighteen multifunctional natural product derivatives were identified including carboxylic acid and ester (1-4, 8-9, 12-13, 15), anthaquinone (5), alkaloids (7, 10-11),  organohalogen  (17), carbonyl (6,14, 16) and thiol (18). The antibiotic compounds observed by scanning electron microscope (SEM) had an impact on the cell membranes, which wilted and collapsed the cell surface. These results may lead to an alternative source of new antibacterial drugs candidates from endophytic bacteria.
Start & End Page 
788 - 799
Received Date 
2015-01-12
Revised Date 
Accepted Date 
2015-05-15
Full Text 
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Correspondence & Author Name 
Wiyada Mongkolthanaruk*,
Keyword 
antibacterial activity, Bacillus amyloliquefaciens, endophytic bacteria, fluorinated derivatives
Volume 
Vol.44 No.3 (July 2017)
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Chiang Mai Journal of Science

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