Chiang Mai Journal of Science

Print ISSN: 0125-2526 | eISSN : 2465-3845

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Antimicrobial Metabolites from the Freshwater Fungus Tubeufia longihelicospora Strain GZCC 23-0405

Lijuan Zhang, Jian Ma, Tianming Zhao, Meiyan Han, Dege Zheng, Ruvishika S. Jayawardena, Ausana Mapook and Yongzhong Lu
* Author for corresponding; e-mail address: yzlu@git.edu.cn
Volume: Vol.51 No.4 (July 2024)
Research Article
DOI: https://doi.org/10.12982/CMJS.2024.053
Received: 8 November 2023, Revised: 20 April 2024, Accepted: 22 April 2024, Published: -

Citation: Zhang L., Ma J., Zhao T., Han M., Zheng D., Jayawardena R.S., et al., Antimicrobial metabolites from the freshwater fungus Tubeufia longihelicospora strain GZCC 23-0405, Chiang Mai Journal of Science, 2024; 51(4): e2024053. DOI 10.12982/CMJS.2024.053.

Abstract

     In this study, five metabolites were successfully isolated from the culture medium of Tubeufia longihelicospora strain GZCC 23-0405, comprising two dimeric naphtha-γ-pyrones (1–2), two dimeric coumarins (3–4), and one alkaloid (5). The elucidation of their chemical structures relied on a combination of NMR, MS, and optical rotation methods. Interestingly, these compounds represent the first instances of such metabolites being isolated from helicosporous hyphomycetes. Additionally, compounds (1) and (2) exhibited significant antimicrobial potential, with MIC and MBC values of 62.0 μg mL-1 and 248 μg mL-1, respectively, against Pseudomonas aeruginosa. This study provides a comprehensive account of the extraction, isolation, structural characterization, and antimicrobial properties of these compounds, shedding light on their potential significance in the field of natural product research.

Keywords: antimicrobial, freshwater fungi, secondary metabolites

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