Chiang Mai Journal of Science

Print ISSN: 0125-2526 | eISSN : 2465-3845

2,424
Articles
Q3 0.80
Impact Factor
Q2 1.6
CiteScore
7 days
Avg. First Decision
Outline
Figures and Tables
ARTICLE METRICS
Views 2,591
Downloads 428

Synthesis and Biological Evaluation of Sulfamoyl Carboxamide Derivatives from Sulfur-containing α-Amino acids

Melford C. Egbujor, Uchechukwu C. Okoro, Attah S. Egu, Vivian I. Okonkwo, Sunday N. Okafor, Chigbundu N. Emeruwa, Pius I. Egwuatu, Odera R. Umeh, Mercy I. Eziafakaego, Ifeanyi S. Amasiatu and David C. Nwobodo
* Author for corresponding; e-mail address: nwobododave@gmail.com, egbujormc@gmail.com
Volume: Vol.49 No.4 (July 2022)
Research Article
DOI: https://doi.org/10.12982/CMJS.2022.070
Received: 8 March 2022, Revised: 21 May 2022, Accepted: 25 May 2022, Published: -

Citation: Egbujor M.C., Okoro U.C., Egu A.S., Okonkwo V.I., Okafor S.N., Emeruwa C.N., et al., Synthesis and biological evaluation of sulfamoyl carboxamide derivatives from sulfur-containing α-amino acids, Chiang Mai Journal of Science, 2022; 49(4): 1100-1115. DOI 10.12982/CMJS.2022.070.

Abstract

    A series of new sulfamoyl carboxamide analogs were synthesized using sulfur-containing amino acids and sulfonyl chloride. The characterization of the compounds was done using FTIR, 1H-NMR, 13C-NMR, and elemental analysis. Their antioxidant, antimalarial, antimicrobial activities and molecular docking were evaluated. Compounds 5h (MIC, 0.3, 0.5, 0.3 and 0.4 mg/mL) was the most potent antibacterial agent against Staphylococcus aureus, Escherichia coli, Bacillus subtilis and Salmonella typhi, compounds 5a (MIC, 0.7 mg/mL) and 5g (MIC, 0.7m g/mL) were most potent against Pseudomonas aeruginosa while compound 5e (MIC, 0.5 and 0.8 mg/mL) had the best in vitro antifungal activity against Aspergillus niger and Candida albicans. Compound 5d (1C50 = 1.128 μg/mL) displayed an antioxidant activity comparable with ascorbic acid (1C50 = 1.000 μg/mL) and compound 5e (4, 14, 4%) effected the most significant reduction in the percentage malaria parasitaemia comparable with artemeter lumefantrin (5, 4, 4%) after 5 days of treatment of the mice. From the molecular docking results, compound 5c had a strong molecular interaction with the appropriate drug target, Escherichia coli DNA gyrase complexed with 1-ethyl-3-[8-methyl-5-(2-methyl-pyridin-4-yl) isoquinolin-3-yl]urea (PDB code: 5MMN). The title compounds displayed signifi cant antimicrobial, antioxidant and antimalarial activities.

Keywords: antimalarial, antimicrobial, antioxidant, carboxamide, sulphonamide, methionine, cysteine, molecular docking

Related Articles

Comparative Analysis of Leaf Micromorphology, Phytochemical Profiles, and Antioxidant Activity in Two Vallaris Species (Apocynaceae)
DOI: 10.12982/CMJS.2026.039.

Siriphan Sukkhaeng, Piyanan Thanomchat, Sunipa Detpitthayanan and Yupadee Paopun*

Vol.53 No.3 (May 2026)
Research Article View: 395 Download: 82
Coumarin-Based Thiosemicarbazones: Molecular Docking, ADMET Analysis, Synthesis, and α-Glucosidase Inhibition
DOI: 10.12982/CMJS.2026.037.

Muhammad Shahid Nazir, Matloob Ahmad* and Azhar Rasul

Vol.53 No.2 (March 2026)
Research Article View: 305 Download: 56
Enhancement of Antioxidant Activity and Inhibition of Polyphenol Oxidase from Green Oak Lettuce by Chitosan-Encapsulated Rambutan (Nephelium lappaceum L.) Peel Extract
DOI: 10.12982/CMJS.2025.035.

Panita Kongsune, Kittisak Sangthongchin, Phasin Ampha, Manee Maneechote and Netnapa Chana

Vol.52 No.4 (July 2025)
Research Article View: 1,927 Download: 558
Enhancing the Physicochemical Characteristics and Biological Activities of Phenolic-rich ‘Bignay’ (Antidesma bunius (L.) Spreng.) Fruit Beverage by Two-stage Fermentation
DOI: 10.12982/CMJS.2025.011.

Vince Ellison B. Leyeza, Rona Camille M. Lizardo-Agustin, Lloyd Earl L. Flandez and Katherine Ann T. Castillo-Israel

Vol.52 No.2 (March 2025)
Research Article View: 1,616 Download: 427
Effect of Die Temperature and Porang (Amorphophallus mulleri B.) Flour on the Physicochemical Properties, Nutritional Value, Estimated Glycemic Index, and Sensory Evaluation of Brown Rice Snack by a Collet Extruder
DOI: 10.12982/CMJS.2025.003.

Cindytia Selvina Bernas, Sagar Pandappa Kalahal, Domas Galih Patria and Jenshinn Lin

Vol.52 No.1 (January 2025)
Research Article View: 2,133 Download: 393
Microbiological and Biochemical Characterization, and Sensory Evaluation of Dragon Blood Tea Kombucha
DOI: 10.12982/CMJS.2024.088.

Niphawan Panti, Phatthanapong Therdtatha, Suttida Doungta, Supakan Saenkam, Phisit Seesuriyachan, Pornchai Rachtanapun and Kasirawat Sawangrat

Vol.51 No.6 (November 2024)
Research Article View: 1,868 Download: 1,127
Antimicrobial Metabolites from the Freshwater Fungus Tubeufia longihelicospora Strain GZCC 23-0405
DOI: 10.12982/CMJS.2024.053.

Lijuan Zhang, Jian Ma, Tianming Zhao, Meiyan Han, Dege Zheng, Ruvishika S. Jayawardena, Ausana Mapook and Yongzhong Lu

Vol.51 No.4 (July 2024)
Research Article View: 1,921 Download: 732
Effects of Selected Yeasts on the Chemical Profiles and Antioxidant Activity of Fermented Coffee Beans during the Aging Process
DOI: 10.12982/CMJS.2024.016.

Yi-Ting Chang, Pi-Hui Hsu, Mao-Che Chiu and Jui-Yu Chou

Vol.51 No.1 (January 2024)
Research Article View: 2,212 Download: 555
Evaluation of Alcoholic Extracts of Mucuna pruriens (L.) DC. Var. utilis for Antibacterial, Antioxidant and Cytotoxic Activities toward Human Cancer Cell Lines
DOI: 10.12982/CMJS.2023.045.

Kanokwan Jitpimai, Lukana Ngiwsara, Weeranuch Lang, Thanawan Panichpat, Ratchanee Mingma, Jisnuson Svasti and Jintanart Wongchawalit

Vol.50 No.5 (September 2023)
Research Article View: 2,920 Download: 1,203
Determination of Both Total Phenolic Compound and Antioxidant Capacity of Herbal Teas Using Smartphone Digital Imaging
DOI: 10.12982/CMJS.2022.030.

Hau Van Nguyen, Jaroon Jakmunee, Napaporn Youngvises and Pakorn Preechaburana

Vol.49 No.2 (March 2022)
Research Article View: 2,174 Download: 1,594
Genetic Diversity Assessment Through Morphological, Biological, and Molecular Studies Among Thai Holy Basil Landraces and Commercial Cultivars
page: 1500 - 1510

Ponsit Sathapondecha and Sukhuman Whankaew

Vol.48 No.6 (November 2021)
Research Article View: 2,580 Download: 785
Antioxidant and Antiproliferative Properties of a Chinese Water Chestnut Extract and Its Biologically Active Isolated Compounds
page: 1036 - 1044

Jinfeng Yang, Myong Jo Kim, Weiling Chen, Yong Soo Kwon and Ji Hye Yoo

Vol.48 No.4 (July 2021)
Research Article View: 1,317 Download: 134
Alpha-Glucosidase Inhibition and Molecular Docking Studies of 4-Hydroxy-N'-[Benzylidene/1-Phenylethylidene]-2H-1,2-Benzothiazine-3-Carbohydrazide 1,1-Dioxides
page: 460 - 469

Furqan Ahmad Saddique, Matloob Ahmad, Usman Ali Ashfaq, Asim Mansha and Samreen Gul Khan

Vol.48 No.2 (March 2021)
Research Article View: 1,206 Download: 1,198
Investigation of Skin Whitening Property of Soybean Seed Protein; Anti-tyrosinase, Anti-inflammation and Antioxidant
page: 150 - 162

Anupong Joompang, Wisarut Payoungkiattikun, Jirayut Dansuk, Napat Nuramrum, Nisachon Jangpromma, Santi Phosri, Bancha Mahong and Sompong Klaynongsruang*

Vol.48 No.1 (January 2021)
Research Article View: 1,927 Download: 1,208
Synthesis, Characterization, Antimicrobial, Antioxidant Activities of Schiff Base and its Transition Metal Complexes
page: 1241 - 1254

Atta Ullah Khan*, Iqbal Hussain and Riaz Ullah

Vol.47 No.6 (November 2020)
Research Article View: 1,359 Download: 624
Antioxidant and Anti-inflammatory Activities of Ethanolic Extract from Hoya kerrii Craib
page: 912 - 925

Patcharawan Sittisart, Benjawan Dunkhunthod and Chokchai Chuea-nongthon

Vol.47 No.5 (September 2020)
Research Article View: 1,761 Download: 748
Molecular Docking Study of Chromone Derivatives as Dual Inhibitor Against Plasmepsin II and Falcipain-2
page: 98 - 113

Chirattikan Maicheen, Jiraporn Ungwitayatorn

Vol.47 No.1 (January 2020)
Research Article View: 1,173 Download: 601
Diptoindonesin D, a Potent Antibacterial Activity Against Gram-positive Bacteria, an Inhibitor of Penicillin-binding Protein 2a from the Stem Bark of Shorea roxburghii G.Don
page: 1161 - 1175

Kanokorn Sudto, Patchreenart Saparpakorn, Chompoonuch Tancharoen, Darinee Phromyothin, Supanna Techasakul, Nisachon Khunnawutmanotham, Srunya Vajrodaya, Hui-Ming Ge, Ren Xiang Tan, and Supa Hannongbua*

Vol.46 No.6 (November 2019)
Research Article View: 1,463 Download: 696
Antioxidant, Anti-tyrosinase, Anti-aging Potentialsand Safety of Arabica Coffee Cherry Extract
page: 930 - 945

Kanokwan Kiattisin*, Nutjeera Intasai, Nichcha Nitthikan, Thananya Nantarat, Kuan-Han Lee, Wei-Chao Lin, Shang-Chian Lue and Pimporn Leelapornpisid

Vol.46 No.5 (September 2019)
Research Article View: 1,494 Download: 664
Antioxidant and Anti-inflammatory Activities of the Siamese Crocodile (Crocodylus Siamensis) Hemoglobin Hydrolysate Derived from Trypsin and Papain Hydrolysis
page: 915 - 929

Jiraporn Lueangsakulthai, Nicholas Michael, Theeranan Temsiripong, Watcharee Khunkitti, Sompong Klaynongsruang, Nisachon Jangpromma*

Vol.46 No.5 (September 2019)
Research Article View: 1,165 Download: 534
Anti-inflammatory, Antioxidant Activities and Safety of Coffea arabica Leaf Extract for Alternative Cosmetic Ingredient
page: 284 - 294

Kanokwan Kiattisin, Nichcha Nitthikan, Worrapan Poomanee, Pimporn Leelapornpisid, Helmut Viernstein and Monika Mueller

Vol.46 No.2 (March 2019)
Research Article View: 1,201 Download: 1,023
Pharmaceutical and Cosmeceutical Biological Activities of Hemp (Cannabis sativa L var. sativa) Leaf and Seed Extracts
page: 180 - 195

Aranya Manosroi, Charinya Chankhampan, Bang-on Kietthanakorn, Warintorn Ruksiriwanich, Puxvadee Chaikul, Korawinwich Boonpisuttinant, Mathukorn Sainakham, Worapaka Manosroi, Theeraphong Tangjai and Jiradej Manosroi

Vol.46 No.2 (March 2019)
Research Article View: 2,090 Download: 662
Phytochemical Investigation and Antioxidant Properties of Different Extracts from Artabotrys harmandii Finet & Gagnep
page: 2338 - 2347

Wararut Bunchareon, Supaporn Pamok, Supap Saenphet and Kanokporn Saenphet

Vol.45 No.6 (September 2018)
Research Article View: 1,234 Download: 464
Comparative GC-MS Analysis, In-vitro Antioxidant and Antimicrobial Activities of the Essential Oils Isolated from the Peel of Omani Lime
page: 1782 - 1795

Amwaj Mohammed Al-Breiki, Huda Mubarak Al-Brashdi, Jamal Nasser Al-Sabahi and Shah Alam Khan

Vol.45 No.4 (July 2018)
Research Article View: 1,500 Download: 366
Chemometric Profiling of Clinacanthus nutans Leaves Possessing Antioxidant Activities using Ultraviolet-visible Spectrophotometry
page: 1519 - 1530

Hui Wen Chong, Khansa Rezaei, Bee Lynn Chew and Vuanghao Lim*

Vol.45 No.3 (May 2018)
Research Article View: 1,190 Download: 381
Synthesis, Docking Studies and Pharmacological Activity of Synthetic Flavonols
page: 1415 - 1425

Mohammad Shoaib [a], Mehreen Ghias*, Niaz Ali, Abdul Wadood, Syed Wadood Ali Shah, Ismail Shah, Shafiullah, Mehreen Ghufran and Mehboob ur Rahman

Vol.45 No.3 (May 2018)
Research Article View: 1,546 Download: 389
Antioxidant and Antimicrobial Properties of Polysaccharides from Rice Brans
page: 1372 - 1382

Siriluck Surin, Phisit Seesuriyachan, Prodpran Thakeow, SangGuan You and Yuthana Phimolsiripol*

Vol.45 No.3 (May 2018)
Research Article View: 1,355 Download: 453
Antioxidant Properties of Crocodylus siamensis Blood Components on H2O2-induced Human Skin Fibroblast Cells
page: 1359 - 1371

Nisachon Jangpromma, Khantheeranut Suttee, Santi Phosri, Tinnakorn Theansungnoen, Jiraporn Lueangsakulthai, Wisarut Payoungkiattikun, Sakda Daduang and Sompong Klaynongsruang*

Vol.45 No.3 (May 2018)
Research Article View: 1,399 Download: 495
Effects of Three Drying Treatments on the Polyphenol Content, Antioxidant and Antimicrobial Properties of Syzygium aromaticum Extract
page: 937 - 948

Suat-HianTan* and Md. Rezaul Karim

Vol.45 No.2 (March 2018)
Research Article View: 1,157 Download: 280
Phenolic Compounds and Antioxidant Activities of Four Edible Species During Seed Germination
page: 905 - 916

Arthitaya Kawee-ai, Pimpak Phumat, Siriporn Okonogi, Srikarnjana Klayraung and Phisit Seesuriyachan*

Vol.45 No.2 (March 2018)
Research Article View: 1,278 Download: 348
Antioxidant, Anti-tyrosinase and Immunomodulatory Activities of the Enzymatic Boiled Venus Clam Hydrolysate
page: 249 - 262

Chanutchamon Sutthiwanjampa and Sang Moo Kim

Vol.45 No.1 (January 2018)
Research Article View: 1,159 Download: 453
Molecular Docking Study of Phthalimide Derivatives as Non-nucleoside HIV-1 Reverse Transcriptase Inhibitor
page: 1395 - 1406

Chirattikan Maicheen, Weerasak Samee and Jiraporn Ungwitayatorn*

Vol.44 No.4 (October 2017)
Research Article View: 1,080 Download: 287
In vitro Anti-aging Activities of Crocodile (Crocodylus siamensis) Blood Extracts
page: 1334 - 1346

Jiradej Manosroi, Charinya Chankhampan, Worapaka Manosroi and Aranya Manosroi*

Vol.44 No.4 (October 2017)
Research Article View: 1,324 Download: 342
Antioxidant, Total Phenolics and Total Flavonoid Content of the Aqueous Extract of Caesalpinia bonducella Seeds
page: 929 - 938

Shruti Shukla* and Archana Mehta

Vol.44 No.3 (July 2017)
Research Article View: 1,245 Download: 478
Innovating Botanical Extraction through Application of Microwaves for the Efficient Extraction of Ursolic Acid from Ocimum sanctum Leaves
page: 869 - 880

Rajendra Mehta, Raj Kumar, Roshni Tandey and Vivekananda Mandal*

Vol.44 No.3 (July 2017)
Research Article View: 1,115 Download: 310
Chemical Profiles and Antimicrobial Activities of Thai Propolis Collected from Apis mellifera
page: 438 - 448

Sirikarn Sanpa [a,b], Milena Popova [c], Tawee Tunkasiri [d], Sukum Eitssayeam [d], Vassya Bankova [

Vol.44 No.2 (April 2017)
Research Article View: 2,055 Download: 477
Ultrasonic Extraction, Antioxidant and Anti-glycation Activities of Polysaccharides from Gynura divaricata Leaves
page: 144 - 156

Pawinee Deetae*[a, e], Kwanrudee Tseng [a], Chanathinart Pasuphan [a], Atikorn Panya [b], Pawadee Methacanon [c], Waranya Temthawee [a] and Manop Suphantharika [d]

Vol.44 No.1 (JANUARY 2017)
Research Article View: 2,466 Download: 417
Phenolic Profile, Fatty Acid and Essential Oil Composition Analysis and Antioxidant, Antialzheimer and Antibacterial Activities of Verbascum flavidum Extracts
page: 1090 - 1101

Mehmet Boğa*[a], Abdulselam Ertaş [b], Nesrin Haşimi [c], Serpil Demirci [d], Mustafa Abdullah Yılmaz [e], Hamdi Temel [f] and Ufuk Kolak [g]

Vol.43 No.5 (OCTOBER 2016)
Research Article View: 1,187 Download: 383
Antioxidant Compounds and Activities in Selected Fresh and Blanched Vegetables from Northeastern Thailand
page: 834 - 844

Thidarat Somdee*[a], Udomsak Mahaweerawat [a], Methin Phadungkit [b] and Suneerat Yangyuen [a]

Vol.43 No.4 (JULY 2016)
Research Article View: 1,129 Download: 294
Synthesis, Characterization and Antioxidant Activity of 2-Halobenzoyl Thiourea bearing α- and β-Alanine
page: 578 - 584

Nurziana Ngah*, Nor Azanita Mohamed, and Deny Susanti Darnis

Vol.43 No.3 (APRIL 2016)
Research Article View: 1,062 Download: 326
Phytochemical Constituents with Antimicrobial and Antioxidant Activities from Xylia xylocarpa (Roxb.) Taub. Sawdust Extracts
page: 11 - 21

Pattarawadee Sumthong Nakmee* [a], Soontree Khuntong [a] and Nitra Nuengchamnong [b]

Vol.43 No.1 (JANUARY 2016)
Research Article View: 1,234 Download: 425
Fatty Acid, Essential Oil and Phenolic Compositions of Alcea pallida and Alcea apterocarpa with Antioxidant, Anticholinesterase and Antimicrobial Activities
page: 89 - 99

Abdulselam Ertas*[a,b], Mehmet Boga [b,c], Isil Gazioglu [d], Yeter Yesil [e] , Nesrin Hasimi [f], Cumali Ozaslan [g], Hasibe Yilmaz[h], Muammer Kaplan[j]

Vol.43 No.1 (JANUARY 2016)
Research Article View: 1,165 Download: 385
Prediction of Antioxidant Capacity of Thai Vegetable Extracts by Infrared Spectroscopy
page: 657 - 668

Trakul Prommajak, Sang Moo Kim, Cheol-Ho Pan, Sang Min Kim, Suthat Surawang, Nithiya

Vol.42 No.3 (JULY 2015)
Research Article View: 1,207 Download: 340
Plasma Assisted Immobilization of TiO2 nanoparticles onto PLA Surface to Promote the Antimicrobial Activity
page: 1361 - 1374

Chonlada Theerakarunwong*[a], Somruthai Tunma[b] and Dheerawan Boonyawan[c]

Vol.41 No.5/2 (OCTOBER 2014)
Research Article View: 1,007 Download: 261
In vitro INHIBITION OF LIPID PEROXIDATION AND THE ANTIOXIDANT SYSTEM OF ENDOPHYTIC FUNGI FROM THAI MEDICINAL PLANTS
page: 429 - 444

Teerayut Theantana [a,b], Duangta Kanjanapothi [c], Saisamorn Lumyong* [b]

Vol.39 No.3 (JULY 2012)
Research Article View: 1,178 Download: 296
Comparative Analysis of Aqueous Extracts of Amaranth and Coriander in Scavenging Free Radical Activity and Protection of DNA against Oxidative Damage
page: 560 - 571

Asmita Dutta and Mukesh Singh

Vol.38 No.4 (OCTOBER 2011)
Research Article View: 1,123 Download: 411
Antioxidant Capacity of Broccoli Seeds Grown in Thailand
page: 117 - 122

Sarunya Chuanphongpanich* [a], Maitree Suttajit [b], Sukon Phanichphant [c Duang Buddhasukh [c]

Vol.33 No.1 (JANUARY 2006)
Research Article View: 1,125 Download: 373
Extraction of Phenolic Compounds from Fruits of Bitter Melon (Momordica charantia ) with Subcritical Water Extraction and Antioxidant Activities of These Extracts
page: 123 - 130

Parichat Budrat and Artiwan Shotipruk

Vol.35 No.1 (JANUARY 2008)
Research Article View: 1,208 Download: 683
Red Yeast Rice Prepared from Thai Glutinous Rice and the Antioxidant Activities
page: 42 - 49

Em-on Chairote, Griangsak Chairote, and Saisamorn Lumyong

Vol.36 No.1 (JANUARY 2009)
Research Article View: 1,302 Download: 380
Screening of Antioxidants from Some Thai Vegetables and Herbs
page: 1 - 5

Anchana Chanwitheesuk, Nuansri Rakariyatham*, Aphiwat Teerawutgulrag and Teerapol Wongchanapiboon

Vol.29 No.1 (APRIL 2002)
Opinion View: 1,305 Download: 372
Antimalarial Activity in Vitro of Some Natural Extracts from Vitex trifolia
page: 9 - 13

Sombat Chowwanapoonpohn and Apiwat Baramee

Vol.27 No.1 (JUNE 2000)
Opinion View: 1,118 Download: 288
Outline
Figures