Pharmaceutical and Cosmeceutical Biological Activities of Hemp (Cannabis sativa L var. sativa) Leaf and Seed Extracts
Aranya Manosroi, Charinya Chankhampan, Bang-on Kietthanakorn, Warintorn Ruksiriwanich, Puxvadee Chaikul, Korawinwich Boonpisuttinant, Mathukorn Sainakham, Worapaka Manosroi, Theeraphong Tangjai and Jiradej Manosroi* Author for corresponding; e-mail address: jiradej.manosroi8@gmail.com
Volume: Vol.46 No.2 (March 2019)
Research Article
DOI:
Received: 14 December 2018, Revised: -, Accepted: 16 January 2019, Published: -
Citation: Manosroi A., Chankhampan C., Kietthanakorn B., Ruksiriwanich W., Chaikul P., Boonpisuttinant K., et al., Pharmaceutical and Cosmeceutical Biological Activities of Hemp (Cannabis sativa L var. sativa) Leaf and Seed Extracts, Chiang Mai Journal of Science, 2019; 46(2): 180-195.
Abstract
The fresh Hemp (Cannabis sativa L var. sativa) leaves and seeds were extracted by maceration in 95% ethanol and investigated for their biological activities. The percentage yields were 3.77±0.31 and 1.58±0.20%, respectively. For cosmeceutical activities, the leaf extract exhibited higher DPPH scavenging, metal chelating and tyrosinase inhibition activity than the seed extract. The leaf extract exhibited pro MMP-2 inhibition (56.27±5.98%) and active MMP-2 inhibition (100%) with the pro MMP-2 inhibition lower than ascorbic acid of 1.11 times. The melanin induction in B16F10 melanoma cells of the leaf extract was 1.06 and 2.22 times of the control and theophylline, respectively. Moreover, it showed 5α-reductase inhibition (13.57±3.21%), but lower than dutasteride of 3.78 times. For pharmaceutical activities, the leaf extract showed anti-bacterial activity on S. mutans which was lower than erythromycin of 17 times and anti-proliferation on HepG2 and KB cell lines (IC50 values=13.17±1.53 and 5.16±1.66 mg/ml), which were lower than doxorubicin of 2,800 and 3,000 time, respectively. The high apoptotic on HeLa cells of the leaf extract was observed at 13.26±7.40%. The seed extract showed lipid peroxidation inhibition and anti-bacterial activity on S. aureus higher than the leaf extract. This study has demonstrated the potential of the Hemp leaf extract which can be further developed for pharmaceutical and cosmeceutical application.
Related Articles
DOI: 10.12982/CMJS.2026.039.
Siriphan Sukkhaeng, Piyanan Thanomchat, Sunipa Detpitthayanan and Yupadee Paopun*
Vol.53 No.3 (May 2026)Research Article View: 503 Download: 110
DOI: 10.12982/CMJS.2025.012.
Sakoolrud Raunmoon, Varintorn Bangwiset, Wanrudee Kaewmesri, Arthid Thim-uam, Paideang Khwanchai, Chee O. Too and Widsanusan Chartarrayawadee
Vol.52 No.2 (March 2025)Research Article View: 1,274 Download: 326
DOI: 10.12982/CMJS.2025.011.
Vince Ellison B. Leyeza, Rona Camille M. Lizardo-Agustin, Lloyd Earl L. Flandez and Katherine Ann T. Castillo-Israel
Vol.52 No.2 (March 2025)Research Article View: 1,732 Download: 435
DOI: 10.12982/CMJS.2025.003.
Cindytia Selvina Bernas, Sagar Pandappa Kalahal, Domas Galih Patria and Jenshinn Lin
Vol.52 No.1 (January 2025)Research Article View: 2,174 Download: 397
DOI: 10.12982/CMJS.2024.106.
Sasi Florence
Vol.51 No.6 (November 2024)Research Article View: 931 Download: 462
DOI: 10.12982/CMJS.2024.088.
Niphawan Panti, Phatthanapong Therdtatha, Suttida Doungta, Supakan Saenkam, Phisit Seesuriyachan, Pornchai Rachtanapun and Kasirawat Sawangrat
Vol.51 No.6 (November 2024)Research Article View: 1,901 Download: 1,129
DOI: 10.12982/CMJS.2024.061.
Meluzvia Marie Amora, Noreen Grace V. Fundador and Erwin Oliver V. Fundador
Vol.51 No.4 (July 2024)Research Article View: 2,637 Download: 622
DOI: 10.12982/CMJS.2024.016.
Yi-Ting Chang, Pi-Hui Hsu, Mao-Che Chiu and Jui-Yu Chou
Vol.51 No.1 (January 2024)Research Article View: 2,238 Download: 558
DOI: 10.12982/CMJS.2024.002.
Wannisa Raksamat and Ingorn Kimkong
Vol.51 No.1 (January 2024)Research Article View: 1,475 Download: 1,584
DOI: 10.12982/CMJS.2023.045.
Kanokwan Jitpimai, Lukana Ngiwsara, Weeranuch Lang, Thanawan Panichpat, Ratchanee Mingma, Jisnuson Svasti and Jintanart Wongchawalit
Vol.50 No.5 (September 2023)Research Article View: 2,956 Download: 1,205
DOI: 10.12982/CMJS.2022.070.
Melford C. Egbujor, Uchechukwu C. Okoro, Attah S. Egu, Vivian I. Okonkwo, Sunday N. Okafor, Chigbundu N. Emeruwa, Pius I. Egwuatu, Odera R. Umeh, Mercy I. Eziafakaego, Ifeanyi S. Amasiatu and David C. Nwobodo
Vol.49 No.4 (July 2022)Research Article View: 2,623 Download: 435
DOI: 10.12982/CMJS.2022.030.
Hau Van Nguyen, Jaroon Jakmunee, Napaporn Youngvises and Pakorn Preechaburana
Vol.49 No.2 (March 2022)Research Article View: 2,210 Download: 1,614
page: 1500 - 1510
Ponsit Sathapondecha and Sukhuman Whankaew
Vol.48 No.6 (November 2021)Research Article View: 2,594 Download: 785
page: 1036 - 1044
Jinfeng Yang, Myong Jo Kim, Weiling Chen, Yong Soo Kwon and Ji Hye Yoo
Vol.48 No.4 (July 2021)Research Article View: 1,327 Download: 134
page: 150 - 162
Anupong Joompang, Wisarut Payoungkiattikun, Jirayut Dansuk, Napat Nuramrum, Nisachon Jangpromma, Santi Phosri, Bancha Mahong and Sompong Klaynongsruang*
Vol.48 No.1 (January 2021)Research Article View: 1,935 Download: 1,208
page: 123 - 134
Minh Thi Hong Nguyen, Lam Luong Nguyen, Tae-Hee Kim, Won-Kyo Jung and Phuong Thi Mai Nguyen*
Vol.48 No.1 (January 2021)Research Article View: 1,154 Download: 908
page: 1265 - 1282
Husna Syaima, Venty Suryanti and Sentot B. Rahardjo
Vol.47 No.6 (November 2020)Research Article View: 1,289 Download: 491
page: 912 - 925
Patcharawan Sittisart, Benjawan Dunkhunthod and Chokchai Chuea-nongthon
Vol.47 No.5 (September 2020)Research Article View: 1,793 Download: 750
page: 930 - 945
Kanokwan Kiattisin*, Nutjeera Intasai, Nichcha Nitthikan, Thananya Nantarat, Kuan-Han Lee, Wei-Chao Lin, Shang-Chian Lue and Pimporn Leelapornpisid
Vol.46 No.5 (September 2019)Research Article View: 1,506 Download: 665
page: 915 - 929
Jiraporn Lueangsakulthai, Nicholas Michael, Theeranan Temsiripong, Watcharee Khunkitti, Sompong Klaynongsruang, Nisachon Jangpromma*
Vol.46 No.5 (September 2019)Research Article View: 1,176 Download: 534
page: 284 - 294
Kanokwan Kiattisin, Nichcha Nitthikan, Worrapan Poomanee, Pimporn Leelapornpisid, Helmut Viernstein and Monika Mueller
Vol.46 No.2 (March 2019)Research Article View: 1,219 Download: 1,023
page: 2566 - 2580
Phennapa Charoenwiwattanakij, Jaturong Pratuangdejkul, Montree Jaturanpinyo, Witaya Lowtangkitcharoen, Khanit Suwanborirux and Veena Nukoolkarn
Vol.45 NO.7 (November 2018)Research Article View: 1,971 Download: 484
page: 2338 - 2347
Wararut Bunchareon, Supaporn Pamok, Supap Saenphet and Kanokporn Saenphet
Vol.45 No.6 (September 2018)Research Article View: 1,253 Download: 464
page: 1782 - 1795
Amwaj Mohammed Al-Breiki, Huda Mubarak Al-Brashdi, Jamal Nasser Al-Sabahi and Shah Alam Khan
Vol.45 No.4 (July 2018)Research Article View: 1,516 Download: 368
page: 1519 - 1530
Hui Wen Chong, Khansa Rezaei, Bee Lynn Chew and Vuanghao Lim*
Vol.45 No.3 (May 2018)Research Article View: 1,207 Download: 382
page: 1372 - 1382
Siriluck Surin, Phisit Seesuriyachan, Prodpran Thakeow, SangGuan You and Yuthana Phimolsiripol*
Vol.45 No.3 (May 2018)Research Article View: 1,378 Download: 455
page: 1359 - 1371
Nisachon Jangpromma, Khantheeranut Suttee, Santi Phosri, Tinnakorn Theansungnoen, Jiraporn Lueangsakulthai, Wisarut Payoungkiattikun, Sakda Daduang and Sompong Klaynongsruang*
Vol.45 No.3 (May 2018)Research Article View: 1,410 Download: 495
page: 937 - 948
Suat-HianTan* and Md. Rezaul Karim
Vol.45 No.2 (March 2018)Research Article View: 1,169 Download: 280
page: 905 - 916
Arthitaya Kawee-ai, Pimpak Phumat, Siriporn Okonogi, Srikarnjana Klayraung and Phisit Seesuriyachan*
Vol.45 No.2 (March 2018)Research Article View: 1,288 Download: 348
page: 846 - 857
Thavatchai Kamoltham, Jiradej Manosroi, Charinya Chankhampan, Worapaka Manosroi and Aranya Manosroi*
Vol.45 No.2 (March 2018)Research Article View: 1,349 Download: 830
page: 249 - 262
Chanutchamon Sutthiwanjampa and Sang Moo Kim
Vol.45 No.1 (January 2018)Research Article View: 1,174 Download: 453
page: 1407 - 1418
Worapaka Manosroi, Charinya Chankhampan, Jiradej Manosroi* and Aranya Manosroi*
Vol.44 No.4 (October 2017)Research Article View: 1,304 Download: 402
page: 1334 - 1346
Jiradej Manosroi, Charinya Chankhampan, Worapaka Manosroi and Aranya Manosroi*
Vol.44 No.4 (October 2017)Research Article View: 1,336 Download: 342
page: 929 - 938
Shruti Shukla* and Archana Mehta
Vol.44 No.3 (July 2017)Research Article View: 1,254 Download: 479
page: 869 - 880
Rajendra Mehta, Raj Kumar, Roshni Tandey and Vivekananda Mandal*
Vol.44 No.3 (July 2017)Research Article View: 1,123 Download: 310
page: 630 - 639
Likit Temprom [a], Suphasinee L. Seet [a,b,c], Patcharaporn Tippayawat [d], Pimsiree Suwanna* [a,b,
Vol.44 No.2 (April 2017)Research Article View: 1,225 Download: 271
page: 487 - 493
Teow Chong Teoh* [a], Hussin A. Rothan [b] and Mohammed Rizman Idid [a,c]
Vol.44 No.2 (April 2017)Research Article View: 996 Download: 303
page: 438 - 448
Sirikarn Sanpa [a,b], Milena Popova [c], Tawee Tunkasiri [d], Sukum Eitssayeam [d], Vassya Bankova [
Vol.44 No.2 (April 2017)Research Article View: 2,067 Download: 478
page: 193 - 202
Nadechanok Jiangseubchatveera, Saisunee Liawruangrath, Aphiwat Teerawutgulrag, Dammrong Santiarwor
Vol.44 No.1 (JANUARY 2017)Research Article View: 1,432 Download: 709
page: 144 - 156
Pawinee Deetae*[a, e], Kwanrudee Tseng [a], Chanathinart Pasuphan [a], Atikorn Panya [b], Pawadee Methacanon [c], Waranya Temthawee [a] and Manop Suphantharika [d]
Vol.44 No.1 (JANUARY 2017)Research Article View: 2,475 Download: 417
page: 1090 - 1101
Mehmet Boğa*[a], Abdulselam Ertaş [b], Nesrin Haşimi [c], Serpil Demirci [d], Mustafa Abdullah Yılmaz [e], Hamdi Temel [f] and Ufuk Kolak [g]
Vol.43 No.5 (OCTOBER 2016)Research Article View: 1,199 Download: 383
page: 834 - 844
Thidarat Somdee*[a], Udomsak Mahaweerawat [a], Methin Phadungkit [b] and Suneerat Yangyuen [a]
Vol.43 No.4 (JULY 2016)Research Article View: 1,140 Download: 295
page: 578 - 584
Nurziana Ngah*, Nor Azanita Mohamed, and Deny Susanti Darnis
Vol.43 No.3 (APRIL 2016)Research Article View: 1,072 Download: 327
page: 11 - 21
Pattarawadee Sumthong Nakmee* [a], Soontree Khuntong [a] and Nitra Nuengchamnong [b]
Vol.43 No.1 (JANUARY 2016)Research Article View: 1,246 Download: 426
page: 89 - 99
Abdulselam Ertas*[a,b], Mehmet Boga [b,c], Isil Gazioglu [d], Yeter Yesil [e] , Nesrin Hasimi [f], Cumali Ozaslan [g], Hasibe Yilmaz[h], Muammer Kaplan[j]
Vol.43 No.1 (JANUARY 2016)Research Article View: 1,176 Download: 385
page: 657 - 668
Trakul Prommajak, Sang Moo Kim, Cheol-Ho Pan, Sang Min Kim, Suthat Surawang, Nithiya
Vol.42 No.3 (JULY 2015)Research Article View: 1,215 Download: 340
page: 126 - 135
Suparin Bunkuna, Tippawan Singtripop and Manaporn Manaboon
Vol.42 No.1 (JANUARY 2015)Research Article View: 1,034 Download: 292
page: 981 - 991
Thanaset Senawong *[a,d], Somprasong Khaopha [a], Suwatchai Misuna [a], Wandee Bunyatratchata [b], N
Vol.41 No.5/1 (OCTOBER 2014)Research Article View: 1,214 Download: 281
page: 429 - 444
Teerayut Theantana [a,b], Duangta Kanjanapothi [c], Saisamorn Lumyong* [b]
Vol.39 No.3 (JULY 2012)Research Article View: 1,189 Download: 296
page: 76 - 83
Prasith Kekuda T. Ramamoorthy, Raghavendra H. LakshmanaShetty, Swathi Devidas, Venugopal T. Mudduraj
Vol.39 No.1 (JANUARY 2012)Research Article View: 994 Download: 385
page: 560 - 571
Asmita Dutta and Mukesh Singh
Vol.38 No.4 (OCTOBER 2011)Research Article View: 1,139 Download: 411
page: 85 - 94
Rudeewan Tungpradit, Supachok Sinchaikul, Suree Phutrakul, Weerah Wongkham, Shui-Tein Chen
Vol.38 No.1 (JANUARY 2011)Research Article View: 1,526 Download: 279
page: 117 - 122
Sarunya Chuanphongpanich* [a], Maitree Suttajit [b], Sukon Phanichphant [c Duang Buddhasukh [c]
Vol.33 No.1 (JANUARY 2006)Research Article View: 1,132 Download: 373
page: 123 - 130
Parichat Budrat and Artiwan Shotipruk
Vol.35 No.1 (JANUARY 2008)Research Article View: 1,237 Download: 687
page: 42 - 49
Em-on Chairote, Griangsak Chairote, and Saisamorn Lumyong
Vol.36 No.1 (JANUARY 2009)Research Article View: 1,317 Download: 386
page: 160 - 164
Kodchakorn Lapmak, Saisamorn Lumyong, Sutheera Thongkuntha, Pairote Wongputtisin, and Uraporn Sardsu
Vol.37 No.1 (JANUARY 2010)Short Communication View: 1,171 Download: 294
page: 1 - 5
Anchana Chanwitheesuk, Nuansri Rakariyatham*, Aphiwat Teerawutgulrag and Teerapol Wongchanapiboon
Vol.29 No.1 (APRIL 2002)Opinion View: 1,324 Download: 373
page: 476 - 488
Rudeewan Tungpradit, Supachok Sinchaikul, Suree Phutrakul, Weerah Wongkham and Shui-Tein Chen
Vol.37 No.3 (SEPTEMBER 2010)Research Article View: 1,128 Download: 1,039