Phytochemical Screening, Phenolic and Flavonoid Contents, Antioxidant and Cytotoxic Activities of Graptophyllum pictum (L.) Griff.

Nadechanok Jiangseubchatveera; Saisunee Liawruangrath; Aphiwat Teerawutgulrag; Dammrong Santiarwor

Phytochemical Screening, Phenolic and Flavonoid Contents, Antioxidant and Cytotoxic Activities of Graptophyllum pictum (L.) Griff.

Nadechanok Jiangseubchatveera, Saisunee Liawruangrath, Aphiwat Teerawutgulrag, Dammrong Santiarwor
* Author for corresponding; e-mail address: liawruangrath@gmail.com
Volume: Vol.44 No.1 (JANUARY 2017)
Research Article
DOI:
Received: 19 December 2013, Revised: -, Accepted: 13 December 2014, Published: -

Citation: Jiangseubchatveera N., Liawruangrath S., Teerawutgulrag A. and Santiarwor D., Phytochemical Screening, Phenolic and Flavonoid Contents, Antioxidant and Cytotoxic Activities of Graptophyllum pictum (L.) Griff., Chiang Mai Journal of Science, 2017; 44(1): 193-202.

Abstract

The phytochemical screening of the leaves of Graptophyllum pictum (L.) Griff. was carried out using the standard procedures which revealed the presence of flavonoids, steroids, tannins, coumarins, saponins, anthraquinones, phenolics and sugars. In vitro antioxidant activity, total phenolic and total flavonoid contents of four different fractions from the ethanolic leave extract of G. pictum (L.) Griff. were determined using spectrophotometric methods. The ethyl acetate fraction showed the highest total phenolic content (102.57 ± 0.19 mg gallic acid equivalent/g) and the hexane fraction contained the highest flavonoid (28.21 ± 0.04 mg quercetin equivalent/g). The ethyl acetate fraction also exhibited the highest antioxidant capacities in the DPPH radical scavenging assay with the IC₅₀ value of 0.78 ± 0.01 mg/mL and was found 69.19 ± 0.73 mg trolox equivalent capacity/g and 48.04 ± 0.49 mg ascorbic acid equivalent capacity/g when investigating by the ABTS radical scavenging assay. Moreover, the hexane, the ethyl acetate and the aqueous fractions exhibited significant cytotoxicity against MCF-7 cell lines with IC₅₀ values of 38.66, 26.01 and 20.41 μg/mL, respectively. All fractions were non-cytotoxic against Vero cells. The results of all experiments suggest that the leaves of G. pictum (L.) Griff. can be a natural candidate for rich source of antioxidants for further chemical investigation.

Keywords: Phytochemical screening, Phenolic content, Flavonoid content, Antioxidant activity, Cytotoxicity, Graptophyllum pictum (L.) Griff

Development and Evaluation of Buckwheat-Fortified Mung Bean Extrudates: Effects on Physicochemical, Textural, and Antioxidant Properties
DOI: 10.12982/CMJS.2025.100.

Girish Ningappa Mathad and Jenshinn Lin

Vol.52 No.6 (November 2025)
Research Article View: 448 Download: 93

Exploring the Effect of Incubation pH, Temperature, and In Vitro Digestion on Antioxidant Potential of Mung Bean Protein Hydrolysates
DOI: 10.12982/CMJS.2024.090.

Zohreh Karami and Kiattisak Duangmal

Vol.51 No.6 (November 2024)
Research Article View: 1,010 Download: 324

Effects of Simulated Digestion on the Bioaccessibility of Phenolic Compounds and Antioxidant Activity of Dehydrated Bignay [Antidesma bunius (L.) Spreng]
DOI: 10.12982/CMJS.2024.032.

Ara Fatima A. Carbonera, Liezl M. Atienza, Maria Amelita C. Estacio, Sheba Mae M. Duque, Rona Camille M. Lizardo-Agustin, and Katherine Ann T. Castillo-Israel

Vol.51 No.2 (March 2024)
Research Article View: 1,598 Download: 507

Phytochemical Constituents and Potential of Different Extracts from Eleutherine bulbosa on Skin Infectious Treatment : Anti-fungal, Anti-bacterial, Anti-inflammatory and Cytotoxic Activities
DOI: 10.12982/CMJS.2024.002.

Wannisa Raksamat and Ingorn Kimkong

Vol.51 No.1 (January 2024)
Research Article View: 1,383 Download: 1,571

Effects of Aqueous Extraction Factors on Commercial Protease Inhibitory Activities, Phenolic Acid Profiles and Chemical Properties of Hom Mali-105 Rice (Oryza sativa L.) Bran Extract
DOI: 10.12982/CMJS.2023.054.

Worachai Wongwatcharayothin, Supawan Thawornchinsombut and Akkasit Jongjareonrak

Vol.50 No.5 (September 2023)
Research Article View: 1,629 Download: 950

Evaluation of Alcoholic Extracts of Mucuna pruriens (L.) DC. Var. utilis for Antibacterial, Antioxidant and Cytotoxic Activities toward Human Cancer Cell Lines
DOI: 10.12982/CMJS.2023.045.

Kanokwan Jitpimai, Lukana Ngiwsara, Weeranuch Lang, Thanawan Panichpat, Ratchanee Mingma, Jisnuson Svasti and Jintanart Wongchawalit

Vol.50 No.5 (September 2023)
Research Article View: 2,826 Download: 1,190

Efficacy of Dried Indian Gooseberry Kombucha on a Pre–industrial Scale: Chemical Composition, Antioxidant and Antibacterial Activity
DOI: 10.12982/CMJS.2023.034.

Tharinee Klawpiyapamornkun, Thida Kaewkod, Toungporn Uttarotai, Sunanta Wangkarn, Panee Sirisa-ard, Suwalee Kiatkarun, Yingmanee Tragoolpua and Sakunnee Bovonsombut

Vol.50 No.3 (May 2023)
Research Article View: 1,550 Download: 816

Berberine Loaded Nanoparticles Induce Apoptosis in Human Fibrosarcoma Cells
page: 123 - 134

Minh Thi Hong Nguyen, Lam Luong Nguyen, Tae-Hee Kim, Won-Kyo Jung and Phuong Thi Mai Nguyen*

Vol.48 No.1 (January 2021)
Research Article View: 1,121 Download: 900

Potent Antioxidant Activities of Half-Sib Families of Eucalyptus camaldulensis Dehnh. Leaf Essential Oils Planted in Thailand and Their Antioxidative Components
page: 112 - 122

Sapit Diloksumpun, Preeya Jeenho, Samran Namkhot, Tharinee Saleepochn, Suwaporn Luangkamin*

Vol.48 No.1 (January 2021)
Research Article View: 1,425 Download: 552

Multi-response Optimization of Ultrasonic Assisted Enzymatic Extraction of Antioxidant Polysaccharides from Waste Ginkgo biloba Sarcotesta
page: 499 - 512

Gui-Sheng Zhou, Yu-Ping Tang, Yao Li and Jin-Ao Duan

Vol.47 No.3 (May 2020)
Research Article View: 1,297 Download: 2,116

Solvent Extraction and Measurement of Antioxidant Activity and Total Phenolic Content from Capsicum chinense Jacq. Cv Habanero at Different Maturity Stages
page: 661 - 671

Víctor Manuel Moo-Huchin*, María de Lourdes Vargas y Vargas , Jorge Abraham Tamayo-Cortez, Daniel Arcángel López-Sauri, Enrique Sauri-Duch, Alejandro Ortiz-Fernández, César Abraham Can-Cauich, David Betancur-Ancona

Vol.46 No.4 (July 2019)
Research Article View: 1,183 Download: 451

Optimization of Ultrasonic-assisted Extraction Using Taguchi Design and In vivo Activities ofPolysaccharides from Flos populi
page: 510 - 522

Ying Zhang, Jiaxuan Li, Zheng Jia, Jianqing Chen, Chunbo Gao and Zunlai Sheng

Vol.46 No.3 (May 2019)
Research Article View: 1,130 Download: 341

Pharmaceutical and Cosmeceutical Biological Activities of Hemp (Cannabis sativa L var. sativa) Leaf and Seed Extracts
page: 180 - 195

Aranya Manosroi, Charinya Chankhampan, Bang-on Kietthanakorn, Warintorn Ruksiriwanich, Puxvadee Chaikul, Korawinwich Boonpisuttinant, Mathukorn Sainakham, Worapaka Manosroi, Theeraphong Tangjai and Jiradej Manosroi

Vol.46 No.2 (March 2019)
Research Article View: 2,022 Download: 662

Antibacterial, Antioxidant Properties and Bioactive Compounds of Thai Cultivated Mushroom Extracts Against Food-borne Bacterial Strains
page: 1713 - 1727

Mathurot Chaiharn, Waya S. Phutdhawong, Doungporn Amornlerdpison and Weerachai Phutdhawong

Vol.45 No.4 (July 2018)
Research Article View: 1,328 Download: 546

Antibacterial and Antioxidant Activities of 3-O-methyl Ellagic Acid from Stem Bark of Polyalthia longifolia Thw.
page: 858 - 867

Pankaj Kumar Jain, Arjun Patra*+, Swaha Satpathy, Sonika Jain and Saleemulla Khan

Vol.45 No.2 (March 2018)
Research Article View: 1,201 Download: 366

In vitro Anti-aging Activities of Centotheca lappacea (L) desv. (Ya Repair) Extract
page: 846 - 857

Thavatchai Kamoltham, Jiradej Manosroi, Charinya Chankhampan, Worapaka Manosroi and Aranya Manosroi*

Vol.45 No.2 (March 2018)
Research Article View: 1,310 Download: 785

Antioxidant Activity and Starch-digesting Enzyme Inhibition of Selected Thai Herb Extracts
page: 263 - 276

Krittalak Pasakawee, Somdet Srichairatanakool, Thunnop Laokuldilok and Niramon Utama-ang

Vol.45 No.1 (January 2018)
Research Article View: 1,212 Download: 296

In vitro Anti-aging Activities of Crocodile (Crocodylus siamensis) Blood Extracts
page: 1334 - 1346

Jiradej Manosroi, Charinya Chankhampan, Worapaka Manosroi and Aranya Manosroi*

Vol.44 No.4 (October 2017)
Research Article View: 1,294 Download: 341

Antioxidant, Total Phenolics and Total Flavonoid Content of the Aqueous Extract of Caesalpinia bonducella Seeds
page: 929 - 938

Shruti Shukla* and Archana Mehta

Vol.44 No.3 (July 2017)
Research Article View: 1,216 Download: 477

Carotenoid Composition and Antioxidant Activity of Extracts From Tropical Fruits
page: 605 - 616

V ctor M. Moo-Huchin [a], Gustavo A. Gonz lez-Aguilar [b], Mariela Moo-Huchin [c], Elizabeth Ortiz-V zquez [d], Luis Cuevas-Glory [d], Enrique Sauri-Duch [d] and David Betancur-Ancona* [e]

Vol.44 No.2 (April 2017)
Research Article View: 1,135 Download: 1,060

Antioxidant and Antimicrobial Properties of a Brown Alga Scytosiphon lomentaria
page: 595 - 604

Xiao Juan Xu, Yu Zhang, Hong Lin, Chao Kang, Xiao Ting Fu*

Vol.44 No.2 (April 2017)
Research Article View: 1,139 Download: 282

Antioxidant Activities and Stability of Seed Kernel Extracts from Mango (Mangifera indica linn.) Cultivated in Northern Thailand
page: 573 - 583

Nichana Nakpanich, Wantida Chaiyana and Pimporn Leelapornpisid*

Vol.44 No.2 (April 2017)
Research Article View: 1,275 Download: 402

Evaluation of Biphenylalanine and Its Derivatives as Potential HIV-1 gp120 Attachment Inhibitors Based on Molecular Docking, CD4 Capture ELISA and Cytotoxicity Analysis Entry Inhibitor of HIV-1 gp120
page: 487 - 493

Teow Chong Teoh* [a], Hussin A. Rothan [b] and Mohammed Rizman Idid [a,c]

Vol.44 No.2 (April 2017)
Research Article View: 970 Download: 303

Polyphenol Contents, Antioxidant and Anticancer Activity (MCF-7) of Soybean Products in Thailand
page: 176 - 183

Thidarat Somdee *, Udomsak Mahaweerawat, Jindawan Wibulutai, Namphuang Dungkokruad and Suneerat Yung

Vol.44 No.1 (JANUARY 2017)
Research Article View: 1,231 Download: 1,912

Determination of Antioxidant and Anticancer Activities together with Total Phenol and Flavonoid Contents of Cleidion javanicum Bl. and Bridelia retusa (L.) A. Juss.
page: 535 - 546

Duangsuree Sanseera, Boonsom Liawruangrath *, Stephen G. Pyne and Saisunee Liawruangrath*

Vol.43 No.3 (APRIL 2016)
Research Article View: 1,603 Download: 885

Optimization of the Preparation of Gelatin Hydrolysates with Antioxidative Activity from Lizardfish (Saurida spp.) Scales Gelatin
page: 68 - 79

Sutee Wangtueai [a, b]*, Susanne Siebenhandl-Ehn [c] and Dietmar Haltrich [c]

Vol.43 No.1 (JANUARY 2016)
Research Article View: 1,321 Download: 560

Antioxidant Capacity and Phenolic Content Evaluation on Peanut Skins from 3 Peanut Types
page: 123 - 137

Pornnapa Chuenchom, Prasan Swatsitang, Thanaset Senawong, Sanun Jogloy

Vol.43 No.1 (JANUARY 2016)
Research Article View: 1,243 Download: 595

Comparative Studies on Chemical Composition, Phenolic Compounds and Antioxidant Activities of Brown and White Perilla (Perilla frutescens) Seeds
page: 896 - 906

Sikeret Kongkeaw, Siriporn Riebroy and Manat Chaijan

Vol.42 No.4 (OCTOBER 2015)
Research Article View: 1,179 Download: 351

Fatty Acid Composition, Physical Properties, Acute Oral Toxicity and Antioxidant Activity of Crude Lipids from Adipose Tissue of Some Commercialized Freshwater Catfish
page: 626 - 636

Wiwat Wangcharoen, Kriangsak Mengumphan and Doungporn Amornlerdpison

Vol.42 No.3 (JULY 2015)
Research Article View: 1,106 Download: 268

Phenolics production from a novel substrate palm oil mill effluent by Aspergillus niger IBS-103ZA: Evaluation of fermentation conditions and antioxidant activity
page: 1 - 16

Zulkarnain Mohamed Idris, Parveen Jamal, Md Zahangir Alam, Abdul Haseeb Ansari, A

Vol.42 No.1 (JANUARY 2015)
Research Article View: 1,136 Download: 313

In vitro Antioxidant and Antitumor Activities of an Endophytic Fungus Phomopsis liquidambari QH4 from Artemisia annua
page: 992 - 1006

Yixin Qian [a, b], Jichuan Kang*[a, c], Lu Wang [a], Bangxing Lei [a] and Kevin D. Hyde [d, e]

Vol.41 No.5/1 (OCTOBER 2014)
Research Article View: 1,136 Download: 306

Physical Characteristics and Biological Activities of Thai Flower Extracts Loaded in Niosomes
page: 603 - 617

Aranya Manosroi*[a,b], Bang-on Kietthanakorn [b], Charinya Chankhampan [b], Narinthorn Khositsuntiwo

Vol.40 No.4 (OCTOBER 2013)
Research Article View: 1,148 Download: 365

Antimicrobial and Antioxidant Activities of Methanol, Dichloromethane and Ethyl Acetate Extracts of Scutellaria lindbergii Rech.f.
page: 49 - 59

Bibi Sedigheh Fazly-Bazzaz *[a], Atefeh Arab [b], Seyed Ahmad Emami [c], Javad Asili [c], Mohamad Ha

Vol.40 No.1 (JANUARY 2013)
Research Article View: 1,114 Download: 337

Antioxidant Potential of Pleurotus porrigens Extract and Application in Sunflower Oil during Accelerated Storage
page: 34 - 48

Hip Seng Yim*[a, b], Fook Yee Chye [b], Mei Lian Liow [a], and Chun Wai Ho [a]

Vol.40 No.1 (JANUARY 2013)
Research Article View: 1,137 Download: 363

Nutritional and Physicochemical Qualities of Thua Nao (Thai Traditional Fermented Soybean)
page: 562 - 574

Katekan Dajanta1,2, Ekachai Chukeatirote3,* and Arunee Apichartsrangkoon2

Vol.39 No.4 (OCTOBER 2012)
Research Article View: 1,120 Download: 348

Antioxidant, Antibacterial, Anticancer Activities and Chemical Constituents of the Essential Oil from Mesua ferrea Leaves
page: 455 - 463

Sukanya Keawsa-ard* [a] and Samart Kongtaweelert [b]

Vol.39 No.3 (JULY 2012)
Research Article View: 1,221 Download: 629

Antifungal and Cytotoxic Activity ofEverniastrum cirrhatum (Fr.) Hale
page: 76 - 83

Prasith Kekuda T. Ramamoorthy, Raghavendra H. LakshmanaShetty, Swathi Devidas, Venugopal T. Mudduraj

Vol.39 No.1 (JANUARY 2012)
Research Article View: 959 Download: 383

L-Asparaginase Production by Bipolaris sp. BR438 Isolated from Brown Rice in Thailand
page: 160 - 164

Kodchakorn Lapmak, Saisamorn Lumyong, Sutheera Thongkuntha, Pairote Wongputtisin, and Uraporn Sardsu

Vol.37 No.1 (JANUARY 2010)
Short Communication View: 1,147 Download: 291

Antioxidant and Anti-inflammatory Activities of Brown Marine Alga, Padina minor Yamada
page: 507 - 516

Yuwadee Peerapornpisal, Doungporn Amornlerdpison, Utan Jamjai, Tawat Taesotikul, Yanee Pongpaibul,

Vol.37 No.3 (SEPTEMBER 2010)
Research Article View: 1,173 Download: 380

Anti-Cancer Compound Screening and Isolation: Coscinium fenestratum Tinospora crispa and Tinospora cordifolia
page: 476 - 488

Rudeewan Tungpradit, Supachok Sinchaikul, Suree Phutrakul, Weerah Wongkham and Shui-Tein Chen

Vol.37 No.3 (SEPTEMBER 2010)
Research Article View: 1,095 Download: 1,037

Chiang Mai Journal of Science

1,647

Q3 0.80

Q3 1.3

7 days

Outline

Figures and Tables