Chiang Mai Journal of Science

Phenolic Profile, Fatty Acid and Essential Oil Composition Analysis and Antioxidant, Antialzheimer and Antibacterial Activities of Verbascum flavidum Extracts

Paper Type	Contributed Paper
Title	Phenolic Profile, Fatty Acid and Essential Oil Composition Analysis and Antioxidant, Antialzheimer and Antibacterial Activities of Verbascum flavidum Extracts
Author	Mehmet Boğa*[a], Abdulselam Ertaş [b], Nesrin Haşimi [c], Serpil Demirci [d], Mustafa Abdullah Yılmaz [e], Hamdi Temel [f] and Ufuk Kolak [g]
Email	mehmetboga1980@gmail.com; mehmet.boga@dicle.edu.tr
Abstract: This paper is the first report about phytochemical analysis with LC-MS/MS and biological activities of Verbascum flavidum (Boiss.) Freyn & Bornm. Rutin (1077.09±77.47 µg analyte/g extract) and chlorogenic acid (1012.42±97.18 µg analyte/g extract) were determined the most abundant phenolics in V. flavidum. The main components of fatty acid were found to be palmitic (30.3%) and oleic acids (17.9%); while the major essential oils were determined as arachidic acid (16.4%) and α-selinene (8.9%) by GC-MS analysis. In DPPH free radical scavenging activity the methanol extract showed higher activity than BHT with 72.62% inhibition at 100 µg/mL concentration. The methanol and water extracts of V. flavidum showed 86.01 % and 87.39 % inhibition in ABTS cation radical scavenging assay at 100 μg/mL concentration, respectively. The methanol extract showed moderate activity against E. coli with 250±0.3 MIC value and with 15 mm inhibition zone diameter at 30 mg/mL concentration.
Start & End Page	1090 - 1101
Received Date	2014-12-12
Revised Date
Accepted Date	2015-04-12
Full Text	Download
Keyword	Verbascum flavidum, antioxidant, anticholinesterase, antimicrobial, LC-MS/MS, GC-MS
Volume	Vol.43 No.5 (OCTOBER 2016)
DOI
SDGs
View:527 Download:150