Chiang Mai Journal of Science

Print ISSN: 0125-2526 | eISSN : 2465-3845

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Phenolic Profile, Fatty Acid and Essential Oil Composition Analysis and Antioxidant, Antialzheimer and Antibacterial Activities of Verbascum flavidum Extracts

Mehmet Boğa*[a], Abdulselam Ertaş [b], Nesrin Haşimi [c], Serpil Demirci [d], Mustafa Abdullah Yılmaz [e], Hamdi Temel [f] and Ufuk Kolak [g]
* Author for corresponding; e-mail address: mehmetboga1980@gmail.com; mehmet.boga@dicle.edu.tr
Volume: Vol.43 No.5 (OCTOBER 2016)
Research Article
DOI:
Received: 12 December 2014, Revised: -, Accepted: 12 April 2015, Published: -

Citation: Boğa M., Ertaş A., Haşimi N., Demirci S., Yılmaz M.A., Temel H., et al., Phenolic Profile, Fatty Acid and Essential Oil Composition Analysis and Antioxidant, Antialzheimer and Antibacterial Activities of Verbascum flavidum Extracts, Chiang Mai Journal of Science, 2016; 43(5): 1090-1101.

Abstract

This paper is the first report about phytochemical analysis with LC-MS/MS and biological activities of Verbascum flavidum (Boiss.) Freyn & Bornm. Rutin (1077.09±77.47 µg analyte/g extract) and chlorogenic acid (1012.42±97.18 µg analyte/g extract) were determined the most abundant phenolics in V. flavidum. The main components of fatty acid were found to be palmitic (30.3%) and oleic acids (17.9%); while the major essential oils were determined as arachidic acid (16.4%) and α-selinene (8.9%) by GC-MS analysis. In DPPH free radical scavenging activity the methanol extract showed higher activity than BHT with 72.62% inhibition at 100 µg/mL concentration. The methanol and water extracts of V. flavidum showed 86.01 % and 87.39 % inhibition in ABTS cation radical scavenging assay at 100 μg/mL concentration, respectively. The methanol extract showed moderate activity against E. coli with 250±0.3 MIC value and with 15 mm inhibition zone diameter at 30 mg/mL concentration.

Keywords: Verbascum flavidum, antioxidant, anticholinesterase, antimicrobial, LC-MS/MS, GC-MS

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V ctor M. Moo-Huchin [a], Gustavo A. Gonz lez-Aguilar [b], Mariela Moo-Huchin [c], Elizabeth Ortiz-V zquez [d], Luis Cuevas-Glory [d], Enrique Sauri-Duch [d] and David Betancur-Ancona* [e]

Vol.44 No.2 (April 2017)
Research Article View: 1,038 Download: 1,054
Antioxidant and Antimicrobial Properties of a Brown Alga Scytosiphon lomentaria
page: 595 - 604

Xiao Juan Xu, Yu Zhang, Hong Lin, Chao Kang, Xiao Ting Fu*

Vol.44 No.2 (April 2017)
Research Article View: 1,047 Download: 277
Antioxidant Activities and Stability of Seed Kernel Extracts from Mango (Mangifera indica linn.) Cultivated in Northern Thailand
page: 573 - 583

Nichana Nakpanich, Wantida Chaiyana and Pimporn Leelapornpisid*

Vol.44 No.2 (April 2017)
Research Article View: 1,138 Download: 401
Chemical Profiles and Antimicrobial Activities of Thai Propolis Collected from Apis mellifera
page: 438 - 448

Sirikarn Sanpa [a,b], Milena Popova [c], Tawee Tunkasiri [d], Sukum Eitssayeam [d], Vassya Bankova [

Vol.44 No.2 (April 2017)
Research Article View: 1,873 Download: 473
In vitro Antimicrobial and Cytotoxic Activities of Mangrove Actinomycetes from Eastern Thailand
page: 322 - 337

Janpen Tangjitjaroenkun [a], Rungnapa Tangchitcharoenkhul [b], Waraporn Yahayo [c] and Roongtawan Su

Vol.44 No.2 (April 2017)
Research Article View: 1,005 Download: 228
Phytochemical Screening, Phenolic and Flavonoid Contents, Antioxidant and Cytotoxic Activities of Graptophyllum pictum (L.) Griff.
page: 193 - 202

Nadechanok Jiangseubchatveera, Saisunee Liawruangrath, Aphiwat Teerawutgulrag, Dammrong Santiarwor

Vol.44 No.1 (JANUARY 2017)
Research Article View: 1,253 Download: 686
Polyphenol Contents, Antioxidant and Anticancer Activity (MCF-7) of Soybean Products in Thailand
page: 176 - 183

Thidarat Somdee *, Udomsak Mahaweerawat, Jindawan Wibulutai, Namphuang Dungkokruad and Suneerat Yung

Vol.44 No.1 (JANUARY 2017)
Research Article View: 1,128 Download: 1,909
Ultrasonic Extraction, Antioxidant and Anti-glycation Activities of Polysaccharides from Gynura divaricata Leaves
page: 144 - 156

Pawinee Deetae*[a, e], Kwanrudee Tseng [a], Chanathinart Pasuphan [a], Atikorn Panya [b], Pawadee Methacanon [c], Waranya Temthawee [a] and Manop Suphantharika [d]

Vol.44 No.1 (JANUARY 2017)
Research Article View: 2,299 Download: 413
Photo-remediation of Phenanthrene Contaminated Soil under Visible Light Irradiation
page: 845 - 850

Chonlada Dechakiatkrai Theerakarunwong*[a], and Sukon Phanichphant[b]

Vol.43 No.4 (JULY 2016)
Research Article View: 932 Download: 352
Antioxidant Compounds and Activities in Selected Fresh and Blanched Vegetables from Northeastern Thailand
page: 834 - 844

Thidarat Somdee*[a], Udomsak Mahaweerawat [a], Methin Phadungkit [b] and Suneerat Yangyuen [a]

Vol.43 No.4 (JULY 2016)
Research Article View: 1,008 Download: 291
Synthesis, Characterization and Antioxidant Activity of 2-Halobenzoyl Thiourea bearing α- and β-Alanine
page: 578 - 584

Nurziana Ngah*, Nor Azanita Mohamed, and Deny Susanti Darnis

Vol.43 No.3 (APRIL 2016)
Research Article View: 948 Download: 318
Determination of Antioxidant and Anticancer Activities together with Total Phenol and Flavonoid Contents of Cleidion javanicum Bl. and Bridelia retusa (L.) A. Juss.
page: 535 - 546

Duangsuree Sanseera, Boonsom Liawruangrath *, Stephen G. Pyne and Saisunee Liawruangrath*

Vol.43 No.3 (APRIL 2016)
Research Article View: 1,526 Download: 867
Phytochemical Constituents with Antimicrobial and Antioxidant Activities from Xylia xylocarpa (Roxb.) Taub. Sawdust Extracts
page: 11 - 21

Pattarawadee Sumthong Nakmee* [a], Soontree Khuntong [a] and Nitra Nuengchamnong [b]

Vol.43 No.1 (JANUARY 2016)
Research Article View: 1,083 Download: 424
Identificationof Bioactive Moleculesfrom Thai Centipede, Scolopendra subspinipes dehaani, Venom
page: 1 - 10

Muchalin Meunchan, Nunthawun Uawonggul, Praroonkorn Incamnoi, Sophida Sukprasert, Prapenpuksiri Rungsa, Theerasak Somdee, Sittiruk Roytrakul, Sompong Thammasirirak and Sakda Daduang*

Vol.43 No.1 (JANUARY 2016)
Research Article View: 1,031 Download: 308
Optimization of the Preparation of Gelatin Hydrolysates with Antioxidative Activity from Lizardfish (Saurida spp.) Scales Gelatin
page: 68 - 79

Sutee Wangtueai [a, b]*, Susanne Siebenhandl-Ehn [c] and Dietmar Haltrich [c]

Vol.43 No.1 (JANUARY 2016)
Research Article View: 1,197 Download: 559
Antioxidant Capacity and Phenolic Content Evaluation on Peanut Skins from 3 Peanut Types
page: 123 - 137

Pornnapa Chuenchom, Prasan Swatsitang, Thanaset Senawong, Sanun Jogloy

Vol.43 No.1 (JANUARY 2016)
Research Article View: 1,118 Download: 594
Insights Into The Causes and Anti-hyperglycemic Effects Of Punica granatum Rind in Alloxan-induced Diabetic Rats
page: 112 - 122

Sushil Kumar Middha [a,c], Talambedu Usha [b]* and Veena Pande [a]

Vol.43 No.1 (JANUARY 2016)
Research Article View: 938 Download: 406
Ameliorating Reactive Oxygen Species-Induced in vitro Lipid Peroxidation in Liver, Carbohydrate and DNA Damage by Dendrocalamus hamiltonii Different Leaf Extracts
page: 80 - 88

Arvind Kumar Goyal [a,b], Sushil Kumar Middha [c], Talambedu Usha [c] and Arnab Sen*[a]

Vol.43 No.1 (JANUARY 2016)
Research Article View: 1,005 Download: 245
Fatty Acid, Essential Oil and Phenolic Compositions of Alcea pallida and Alcea apterocarpa with Antioxidant, Anticholinesterase and Antimicrobial Activities
page: 89 - 99

Abdulselam Ertas*[a,b], Mehmet Boga [b,c], Isil Gazioglu [d], Yeter Yesil [e] , Nesrin Hasimi [f], Cumali Ozaslan [g], Hasibe Yilmaz[h], Muammer Kaplan[j]

Vol.43 No.1 (JANUARY 2016)
Research Article View: 1,049 Download: 379
Comparative Studies on Chemical Composition, Phenolic Compounds and Antioxidant Activities of Brown and White Perilla (Perilla frutescens) Seeds
page: 896 - 906

Sikeret Kongkeaw, Siriporn Riebroy and Manat Chaijan

Vol.42 No.4 (OCTOBER 2015)
Research Article View: 1,084 Download: 349
HPTLC Analysis, Antioxidant, Anti-Inflammatory and Xanthine Oxidase Inhibitory Activity of Plumbago zeylanica L
page: 886 - 895

Shivraj Hariram Nile, Umesh Bapurao Patil and Se Won Park

Vol.42 No.4 (OCTOBER 2015)
Research Article View: 1,061 Download: 514
Prediction of Antioxidant Capacity of Thai Vegetable Extracts by Infrared Spectroscopy
page: 657 - 668

Trakul Prommajak, Sang Moo Kim, Cheol-Ho Pan, Sang Min Kim, Suthat Surawang, Nithiya

Vol.42 No.3 (JULY 2015)
Research Article View: 1,083 Download: 334
Determination of the Effects of Adding Milk and Sugar on the Antioxidant Capacity of Oolong Tea by Chemical and Cell Culture-Based Antioxidant Assays
page: 699 - 711

Angkana Wipatanawin, Sudarat Phongsawanit, Thadthanan Maneeratprasert, Sittiwat Lertsiri

Vol.42 No.3 (JULY 2015)
Research Article View: 1,165 Download: 377
Fatty Acid Composition, Physical Properties, Acute Oral Toxicity and Antioxidant Activity of Crude Lipids from Adipose Tissue of Some Commercialized Freshwater Catfish
page: 626 - 636

Wiwat Wangcharoen, Kriangsak Mengumphan and Doungporn Amornlerdpison

Vol.42 No.3 (JULY 2015)
Research Article View: 997 Download: 265
Synthesis, Characterization and Antimicrobial Evaluation of Transition Metal Complexes of Monodentate 2-(Substituted Phenyl)-1H-benzo[d]imidazoles
page: 216 - 227

Minaxi S Maru and Manish K Shah

Vol.42 No.1 (JANUARY 2015)
Research Article View: 1,021 Download: 296
Phenolics production from a novel substrate palm oil mill effluent by Aspergillus niger IBS-103ZA: Evaluation of fermentation conditions and antioxidant activity
page: 1 - 16

Zulkarnain Mohamed Idris, Parveen Jamal, Md Zahangir Alam, Abdul Haseeb Ansari, A

Vol.42 No.1 (JANUARY 2015)
Research Article View: 1,056 Download: 310
Plasma Assisted Immobilization of TiO2 nanoparticles onto PLA Surface to Promote the Antimicrobial Activity
page: 1361 - 1374

Chonlada Theerakarunwong*[a], Somruthai Tunma[b] and Dheerawan Boonyawan[c]

Vol.41 No.5/2 (OCTOBER 2014)
Research Article View: 895 Download: 259
In vitro Antioxidant and Antitumor Activities of an Endophytic Fungus Phomopsis liquidambari QH4 from Artemisia annua
page: 992 - 1006

Yixin Qian [a, b], Jichuan Kang*[a, c], Lu Wang [a], Bangxing Lei [a] and Kevin D. Hyde [d, e]

Vol.41 No.5/1 (OCTOBER 2014)
Research Article View: 1,044 Download: 305
Gastroprotective Effects and Antioxidant Activities of Paederia pilifera Hook.f. Root Extract
page: 1121 - 1131

Kantarat Jirakittirat, Supap Saenphet and Kanokporn Saenphet*

Vol.41 No.5/1 (OCTOBER 2014)
Research Article View: 902 Download: 269
Betel-like-scented Piper Plants as Diverse Sources of Industrial and Medicinal Aromatic Chemicals
page: 1171 - 1181

Arisa Sanubol [a], Arunrat Chaveerach*[a], Runglawan Sudmoon [a], Tawatchai Tanee [b], Kowit Noikotr

Vol.41 No.5/1 (OCTOBER 2014)
Research Article View: 1,673 Download: 310
Phenolic acids content and antioxidant capacity of fruit extracts from Thailand
page: 636 - 642

Nattaya Ongphimai [a], Supathra Lilitchan*[a], Kornkanok Aryusuk [b], Akkarach Bumrungpert [a], et a

Vol.40 No.4 (OCTOBER 2013)
Research Article View: 1,062 Download: 366
Physical Characteristics and Biological Activities of Thai Flower Extracts Loaded in Niosomes
page: 603 - 617

Aranya Manosroi*[a,b], Bang-on Kietthanakorn [b], Charinya Chankhampan [b], Narinthorn Khositsuntiwo

Vol.40 No.4 (OCTOBER 2013)
Research Article View: 1,043 Download: 361
Role of Quercetin and L-Arginine in Alleviating Zinc Oxide Nanoparticle Hepatotoxicity in Rats
page: 577 - 592

Nayira A. Abdel Baky [a]*, L.M. Faddah [a] , Nouf M. Al-Rasheed [a], Nawal M. Al-Rasheed [a] , and W

Vol.40 No.4 (OCTOBER 2013)
Research Article View: 1,013 Download: 321
The Potential of Electrospun Poly(L-lactic Acid) Fiber Mats Containing a Crude Garcinia Dulcis Extract for Use as Wound Dressings
page: 517 - 533

Orawan Suwantong *[a], Porntipa Pankongadisak [a], Suwanna Deachathai [a] and Pitt Supaphol [b]

Vol.40 No.3 (JULY 2013)
Research Article View: 999 Download: 314
Supercritical Fluid Extraction and Gas Chromatographic-Mass Spectrometric Analysis of Terpenoids in Fresh Kaffir Lime Leaf Oil†
page: 240 - 247

Orranuch Norkaew[a], Kitsada Pitija[a], Patcharee Pripdeevech[b], Phumon Sookwong[a], and Sugunya Wo

Vol.40 No.2 (APRIL 2013)
Research Article View: 911 Download: 445
Development of Sequential Injection Analysis Using Peristaltic Pump and Electrochemical Detection for Antioxidant Capacity Test by ABTS Assay
page: 224 - 231

Jakkrapun Kongkedsuk [a], Apisake Hongwitayakorn [a], Wannarekha Bootnapang [b], Nisachon Boonto [b

Vol.40 No.2 (APRIL 2013)
Research Article View: 1,439 Download: 338
Antibacterial Activity and Chemical Composition of Essential Oil and Various Extracts of Fagraea fragrans Roxb. Flowers
page: 214 - 223

Patcharee Pripdeevech* [a] and Jarupux Saansoomchai [b]

Vol.40 No.2 (APRIL 2013)
Research Article View: 1,135 Download: 519
Antimicrobial and Antioxidant Activities of Methanol, Dichloromethane and Ethyl Acetate Extracts of Scutellaria lindbergii Rech.f.
page: 49 - 59

Bibi Sedigheh Fazly-Bazzaz *[a], Atefeh Arab [b], Seyed Ahmad Emami [c], Javad Asili [c], Mohamad Ha

Vol.40 No.1 (JANUARY 2013)
Research Article View: 1,016 Download: 333
Antioxidant Potential of Pleurotus porrigens Extract and Application in Sunflower Oil during Accelerated Storage
page: 34 - 48

Hip Seng Yim*[a, b], Fook Yee Chye [b], Mei Lian Liow [a], and Chun Wai Ho [a]

Vol.40 No.1 (JANUARY 2013)
Research Article View: 1,047 Download: 359
Screening of Volcanic Cave Actinomycetes for Antimicrobial Activity Against Paenibacillus larvae, A Honey Bee Pathogen
page: 26 - 33

Silvia Kay [a], Wasu Pathom-aree [b], and Naowarat Cheeptham*[a]

Vol.40 No.1 (JANUARY 2013)
Research Article View: 1,007 Download: 362
Preparation, characterization, and antimicrobial activity of electrospun nanofibers from cotton waste fibers
page: 712 - 722

Piyaporn Kampeerapappun*

Vol.39 No.4 (OCTOBER 2012)
Research Article View: 885 Download: 243
Antioxidant and Sensory Properties of Thai Herbal Teas with emphasis on Thunbergia laurifolia Lindl.
page: 599 - 609

Eric W.C. Chan*, Suit Ying Eng, Yuen Ping Tan, Zhiew Cheng Wong, Phui Yan Lye, and Lea Ngar Tan

Vol.39 No.4 (OCTOBER 2012)
Research Article View: 1,219 Download: 353
Nutritional and Physicochemical Qualities of Thua Nao (Thai Traditional Fermented Soybean)
page: 562 - 574

Katekan Dajanta1,2, Ekachai Chukeatirote3,* and Arunee Apichartsrangkoon2

Vol.39 No.4 (OCTOBER 2012)
Research Article View: 985 Download: 342
Evaluation of Effective Entomopathogenic Fungi to Fruit Fly Pupa, Bactrocera spp., and Their Antimicrobial Activity
page: 464 - 477

Thet Thet Mar and Saisamorn Lumyong*

Vol.39 No.3 (JULY 2012)
Research Article View: 920 Download: 293
Antioxidant, Antibacterial, Anticancer Activities and Chemical Constituents of the Essential Oil from Mesua ferrea Leaves
page: 455 - 463

Sukanya Keawsa-ard* [a] and Samart Kongtaweelert [b]

Vol.39 No.3 (JULY 2012)
Research Article View: 1,088 Download: 626
In vitro INHIBITION OF LIPID PEROXIDATION AND THE ANTIOXIDANT SYSTEM OF ENDOPHYTIC FUNGI FROM THAI MEDICINAL PLANTS
page: 429 - 444

Teerayut Theantana [a,b], Duangta Kanjanapothi [c], Saisamorn Lumyong* [b]

Vol.39 No.3 (JULY 2012)
Research Article View: 1,031 Download: 294
Comparative Analysis of Aqueous Extracts of Amaranth and Coriander in Scavenging Free Radical Activity and Protection of DNA against Oxidative Damage
page: 560 - 571

Asmita Dutta and Mukesh Singh

Vol.38 No.4 (OCTOBER 2011)
Research Article View: 1,009 Download: 404
Antibacterial Activity of Bauhinia acuminata L. Seed Protein Extract with Low Hemolytic Activity Against Human Erythrocytes
page: 242 - 251

Karaket Phansri [a], Rakrudee Sarnthima [a], Sompong Thammasirirak [b], Pasakorn Boonchalee [c] and

Vol.38 No.2 (APRIL 2011)
Research Article View: 1,074 Download: 277
Antioxidant Capacity of Broccoli Seeds Grown in Thailand
page: 117 - 122

Sarunya Chuanphongpanich* [a], Maitree Suttajit [b], Sukon Phanichphant [c Duang Buddhasukh [c]

Vol.33 No.1 (JANUARY 2006)
Research Article View: 1,013 Download: 367
Extraction of Phenolic Compounds from Fruits of Bitter Melon (Momordica charantia ) with Subcritical Water Extraction and Antioxidant Activities of These Extracts
page: 123 - 130

Parichat Budrat and Artiwan Shotipruk

Vol.35 No.1 (JANUARY 2008)
Research Article View: 1,071 Download: 677
Red Yeast Rice Prepared from Thai Glutinous Rice and the Antioxidant Activities
page: 42 - 49

Em-on Chairote, Griangsak Chairote, and Saisamorn Lumyong

Vol.36 No.1 (JANUARY 2009)
Research Article View: 1,184 Download: 374
GC-MS Analysis of Fatty Acids in Thai Durian Aril
page: 155 - 158

Weerachai Phutdhawong* [a], Sumittra Kaewkong [a] and Duang Buddhasukh [b]

Vol.32 No.2 (MAY 2005)
Short Communication View: 972 Download: 721
Screening of Antioxidants from Some Thai Vegetables and Herbs
page: 1 - 5

Anchana Chanwitheesuk, Nuansri Rakariyatham*, Aphiwat Teerawutgulrag and Teerapol Wongchanapiboon

Vol.29 No.1 (APRIL 2002)
Opinion View: 1,169 Download: 367
Inhibitory Effect of Thermotolerant Lactic Acid Bacteria on the Growth of Bacillus cereus, Staphylococcus aureus, Salmonella enteritidis and Vibrio parahaemolyticus
page: 119 - 124

Atchara Lapmak [a], Sumana Kumpai [b] and Abhinya Plikomol*[b]

Vol.28 No.2 (DECEMBER 2001)
Opinion View: 1,092 Download: 278
Antioxidant and Anti-inflammatory Activities of Brown Marine Alga, Padina minor Yamada
page: 507 - 516

Yuwadee Peerapornpisal, Doungporn Amornlerdpison, Utan Jamjai, Tawat Taesotikul, Yanee Pongpaibul,

Vol.37 No.3 (SEPTEMBER 2010)
Research Article View: 1,075 Download: 375
In vitro Antioxidant Activity of Vitex negundo L. Leaf Extracts
page: 489 - 497

Raghavendra H. Lakshmanashetty, Vijayananda B. Nagaraj, Madhumathi G. Hiremath and Vadlapudi Kumar

Vol.37 No.3 (SEPTEMBER 2010)
Research Article View: 1,575 Download: 1,186
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