Chiang Mai Journal of Science

Print ISSN: 0125-2526 | eISSN : 2465-3845

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Investigation of Skin Whitening Property of Soybean Seed Protein; Anti-tyrosinase, Anti-inflammation and Antioxidant

Anupong Joompang, Wisarut Payoungkiattikun, Jirayut Dansuk, Napat Nuramrum, Nisachon Jangpromma, Santi Phosri, Bancha Mahong and Sompong Klaynongsruang*
* Author for corresponding; e-mail address: somkly@kku.ac.th
Volume: Vol.48 No.1 (January 2021)
Research Article
DOI:
Received: 9 June 2020, Revised: -, Accepted: 22 July 2020, Published: -

Citation: Joompang A., Payoungkiattikun W., Dansuk J., Nuramrum N., Jangpromma N., Phosri S., et al., Investigation of Skin Whitening Property of Soybean Seed Protein; Anti-tyrosinase, Anti-inflammation and Antioxidant, Chiang Mai Journal of Science, 2021; 48(1): 150-162.

Abstract

 This research exhibited that soybean (var. CM. 60) seed protein (3.00 μg/μL protein) was able to inhibit mushroom tyrosinase toward both monophenolase (32.86%) and diphenolase (43.30%). ABTS radical was decreased by 9.30-90.12%, when using 0.016-0.50 μg/μL protein. NO in RAW 264.7 cells was reduced by 10.89-47.77%, when using 0.19-1.50 μg/μL protein. Additionally, a protection toward H2O2-induced HaCaT cell oxidation was also found. ABTS radical scavenging activity and the protection toward H2O2 were contributed by small proteins (<10 kDa) more than large proteins (>10 kDa). The potent protection of <10 kDa (1.50 μg/μg protein) against H2O2 induced HaCaT cell oxidation was observed by increasing the cell viability to be 46.67%, resulting from the decrease of ROS and cell apoptosis. Moreover, CM. 60 protein showed low cytotoxicity toward HaCaT cells and Vero cells. These results suggest that soybean protein could be developed as a safe and potent skin whitening agent.

Keywords: tyrosinase inhibition, antioxidant, soybean protein, anti-inflammation

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