The Potential of Electrospun Poly(L-lactic Acid) Fiber Mats Containing a Crude Garcinia Dulcis Extract for Use as Wound Dressings
Orawan Suwantong *[a], Porntipa Pankongadisak [a], Suwanna Deachathai [a] and Pitt Supaphol [b]* Author for corresponding; e-mail address: o.suwantong@gmail.com
Volume: Vol.40 No.3 (JULY 2013)
Research Article
DOI:
Received: 12 March 2012, Revised: -, Accepted: 9 November 2012, Published: -
Citation: Suwantong O., Pankongadisak P., Deachathai S. and Supaphol P., The Potential of Electrospun Poly(L-lactic Acid) Fiber Mats Containing a Crude Garcinia Dulcis Extract for Use as Wound Dressings, Chiang Mai Journal of Science, 2013; 40(3): 517-533.
Abstract
Electrospun poly(L-lactic acid) (PLLA) fiber mats containing an acetone crude extract of Garcinia dulcis Roxb. (GD) at either amount of 30% or 50% (based on the weight of PLLA) were successfully prepared by electrospinning. Both the neat and the GD-loaded PLLA fibers were smooth, with the average diameters of the fibers ranged between 0.60 and 1.13 mm. The release characteristics of GD from the GD-loaded PLLA fiber mats were carried out by total immersion method in acetate or phosphate buffer solution that contained 0.5% v/v Tween 80 and 3% v/v methanol (hereafter, A/T/M or P/T/M medium) at either 32 or 37ฐC, respectively. The cumulative amounts of the released GD from the GD-loaded PLLA fiber mats in both types of the releasing medium gradually increased with increase in submersion time and then reached a plateau value at the longest submersion investigated time. The antioxidant activity based on the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay of the GD-loaded PLLA fiber mats remained active even after it had been subjected to a high electrical potential during electrospinning process. The antimicrobial activity of the GD-loaded PLLA fiber mats was greatest against Streptococcus pyogenes. Lastly, the GD-loaded PLLA fiber mats were proven non-toxic to normal human dermal fibroblasts, making their potential for use as wound dressings.