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The Potential of Electrospun Poly(L-lactic Acid) Fiber Mats Containing a Crude Garcinia Dulcis Extract for Use as Wound Dressings


Paper Type 
 Contributed Paper
Title 
 The Potential of Electrospun Poly(L-lactic Acid) Fiber Mats Containing a Crude Garcinia Dulcis Extract for Use as Wound Dressings
Author 
 Orawan Suwantong *[a], Porntipa Pankongadisak [a], Suwanna Deachathai [a] and Pitt Supaphol [b]
Email 
 o.suwantong@gmail.com
Abstract:

Electrospun poly(L-lactic acid) (PLLA) fiber mats containing an acetone crude extract of Garcinia dulcis Roxb. (GD) at either amount of 30% or 50% (based on the weight of PLLA) were successfully prepared by electrospinning. Both the neat and the GD-loaded
PLLA fibers were smooth, with the average diameters of the fibers ranged between 0.60 and 1.13

mm. The release characteristics of GD from the GD-loaded PLLA fiber mats were carried out by total immersion method in acetate or phosphate buffer solution that contained 0.5% v/v Tween 80 and 3% v/v methanol (hereafter, A/T/M or P/T/M medium) at either 32 or 37ฐC, respectively. The cumulative amounts of the released GD from the GD-loaded PLLA fiber mats in both types of the releasing medium gradually increased with increase in submersion time and then reached a plateau value at the longest submersion investigated time. The antioxidant activity based on the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay of the
GD-loaded PLLA fiber mats remained active even after it had been subjected to a high electrical potential during electrospinning process. The antimicrobial activity of the GD-loaded PLLA fiber mats was greatest against Streptococcus pyogenes. Lastly, the GD-loaded PLLA fiber mats were proven non-toxic to normal human dermal fibroblasts, making their potential for use as wound dressings.
Start & End Page 
 517 - 533
Received Date 
 2012-03-12
Revised Date 
Accepted Date 
 2012-11-09
Full Text 
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Keyword 
 poly(L-lactic acid), Garcinia dulcis extract, electrospinning, antioxidants, wound dressing
Volume 
 Vol.40 No.3 (JULY 2013)
DOI 
SDGs
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Chiang Mai Journal of Science

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