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Synthesis, Characterization, Antimicrobial, Antioxidant Activities of Schiff Base and its Transition Metal Complexes


Paper Type 
Contributed Paper
Title 
Synthesis, Characterization, Antimicrobial, Antioxidant Activities of Schiff Base and its Transition Metal Complexes
Author 
Atta Ullah Khan*, Iqbal Hussain and Riaz Ullah
Email 
attakhan3711@gmail.com
Abstract:
 The stoichiometric reaction of citronellal with anthranilic acid in methanol was conducted. The reaction was kept on for four hours and stirred at room temperature. Consequently a new product of Schiff base was obtained. The synthesized Schiff base was then allowed to react with chloride salts of different active transition metals, including nickel, cobalt, copper, and zinc, to prepare their complexes. The synthesized Schiff base and its transition metal complexes were characterized by spectroscopic techniques such as 1H-NMR, 13C-NMR, FT-IR. Employing Disc diffusion protocol, Schiff base, and its metal complexes were subjected to antimicrobial assay against two Gram-positive bacterial strains, six Gram-negative bacterial strains, and two fungal strains. Schiff base and its metal complexes exhibited remarkable antimicrobial activity against the tested pathogens. Schiff base is active against all the pathogenic bacteria and fungi. It showed the best inhibition activity against K. pneumonia (18.9mm). None of the complexes was active against S. typhi except the Schiff base (15.8 mm). Among the complexes, NiL2 showed the best inhibition performance. It showed the highest inhibition activity against P. aeruginosa (19.7 mm). All the synthesized compounds were also searched for their antioxidant potential applying DPPH assay. Schiff base and the complexes have significant antioxidant properties. Complex CuL2 has the highest anti-radical potential (73.40 %) followed by NiL2 (72.07%) and CoL2 (70.21%). Complex ZnL2 has exhibited 69.41 % anti-radical performance, while Schiff base has the lowest antioxidant potential (50.79%).
Start & End Page 
1241 - 1254
Received Date 
2019-12-11
Revised Date 
Accepted Date 
2020-04-30
Full Text 
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Keyword 
schiff base, anthranilic acid, citronellal, antioxidants, antimicrobial
Volume 
Vol.47 No.6 (November 2020)
DOI 
Citation 
Khan* A.U., Hussain I. and Ullah R., Synthesis, Characterization, Antimicrobial, Antioxidant Activities of Schiff Base and its Transition Metal Complexes, Chiang Mai Journal of Science, 2020; 47(6): 1241-1254.
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