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New 1,3,4-thiadiazole Derivatives Endowed with Analgesic and Anti-inflammatory Activities


Paper Type 
 Contributed Paper
Title 
 New 1,3,4-thiadiazole Derivatives Endowed with Analgesic and Anti-inflammatory Activities
Author 
 Ajit Kumar Pandey*, Pranita P Kashyap, Chanchal Deep Kaur, Hemant A Sawarkar, Hemant J Dhongade and Mukesh Kumar Singh
Email 
 ajitpandey588@gmail.com
Abstract:
In the present study, novel different Schiff bases of 2,5-disubstituted-1,3,4-thiadiazole were synthesized. The chemical structures were confirmed by IR, 1H NMR and elemental analysis. All the new compounds were tested in vivo for their analgesic and anti-inflammatory activities. Among them in particular compound 5-(2-Mercaptophenyl)-2-{N-(4-methoxybenzylidene)-4-aminophenyl}-1,3,4-thiadiazole 6f was found to have a superior analgesic and anti-inflammatory profile with low gastric ulceration incidence.
Start & End Page 
 917 - 926
Received Date 
 2016-07-09
Revised Date 
Accepted Date 
 2016-11-12
Full Text 
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Keyword 
 analgesic, Anti-inflammatory, schiff bases, thiadiazole
Volume 
 Vol.45 No.2 (March 2018)
DOI 
Citation 
 Pandey A.K., Kashyap P.P., Kaur C.D., Sawarkar H.A., Dhongade H.J. and Singh M.K., New 1,3,4-thiadiazole Derivatives Endowed with Analgesic and Anti-inflammatory Activities, Chiang Mai J. Sci., 2018; 45(2): 917-926.
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Chiang Mai Journal of Science

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