New 1,3,4-thiadiazole Derivatives Endowed with Analgesic and Anti-inflammatory Activities
Ajit Kumar Pandey*, Pranita P Kashyap, Chanchal Deep Kaur, Hemant A Sawarkar, Hemant J Dhongade and Mukesh Kumar Singh* Author for corresponding; e-mail address: ajitpandey588@gmail.com
Volume: Vol.45 No.2 (March 2018)
Research Article
DOI:
Received: 9 July 2016, Revised: -, Accepted: 12 November 2016, Published: -
Citation: Pandey A.K., Kashyap P.P., Kaur C.D., Sawarkar H.A., Dhongade H.J. and Singh M.K., New 1,3,4-thiadiazole Derivatives Endowed with Analgesic and Anti-inflammatory Activities, Chiang Mai Journal of Science, 2018; 45(2): 917-926.
Abstract
In the present study, novel different Schiff bases of 2,5-disubstituted-1,3,4-thiadiazole were synthesized. The chemical structures were confirmed by IR, 1H NMR and elemental analysis. All the new compounds were tested in vivo for their analgesic and anti-inflammatory activities. Among them in particular compound 5-(2-Mercaptophenyl)-2-{N-(4-methoxybenzylidene)-4-aminophenyl}-1,3,4-thiadiazole 6f was found to have a superior analgesic and anti-inflammatory profile with low gastric ulceration incidence.