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New 1,3,4-thiadiazole Derivatives Endowed with Analgesic and Anti-inflammatory Activities
Paper Type  |
Contributed Paper |
Title |
New 1,3,4-thiadiazole Derivatives Endowed with Analgesic and Anti-inflammatory Activities |
Author |
Ajit Kumar Pandey*, Pranita P Kashyap, Chanchal Deep Kaur, Hemant A Sawarkar, Hemant J Dhongade and Mukesh Kumar Singh |
Email |
ajitpandey588@gmail.com |
|
Abstract: In the present study, novel different Schiff bases of 2,5-disubstituted-1,3,4-thiadiazole were synthesized. The chemical structures were confirmed by IR, 1H NMR and elemental analysis. All the new compounds were tested in vivo for their analgesic and anti-inflammatory activities. Among them in particular compound 5-(2-Mercaptophenyl)-2-{N-(4-methoxybenzylidene)-4-aminophenyl}-1,3,4-thiadiazole 6f was found to have a superior analgesic and anti-inflammatory profile with low gastric ulceration incidence. |
|
Start & End Page |
917 - 926 |
Received Date |
2016-07-09 |
Revised Date |
|
Accepted Date |
2016-11-12 |
Full Text |
Download |
Keyword |
analgesic, Anti-inflammatory, schiff bases, thiadiazole |
Volume |
Vol.45 No.2 (March 2018) |
DOI |
|
Citation |
Pandey* A.K., Kashyap P.P., Kaur C.D., Sawarkar H.A., Dhongade H.J. and Singh M.K., New 1,3,4-thiadiazole Derivatives Endowed with Analgesic and Anti-inflammatory Activities, Chiang Mai Journal of Science, 2018; 45(2): 917-926. |
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