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Simultaneous Determination of Nonsteroidal Anti-Inflammatory Drugs Using Vortex-Assisted Liquid-Liquid Microextraction With Back Extraction Coupled With HPLC-UV
Paper Type  |
Contributed Paper |
Title |
Simultaneous Determination of Nonsteroidal Anti-Inflammatory Drugs Using Vortex-Assisted Liquid-Liquid Microextraction With Back Extraction Coupled With HPLC-UV |
Author |
Rania Edrees Adam Mohammad, Elbaleeq Adam Gubartallah, Abdalla Ahmed Elbashir, Bahruddin Saad, Noorfatimah Yahaya, Nur Nadhirah Mohamad Zain, Nurul Yani Rahim and Mazidatulakmam Miskam |
Email |
mazidatul@usm.my |
|
Abstract: A microextraction technique based on vortex-assisted liquid-liquid microextraction with back extraction (VALLME-BE) combined with high-performance liquid chromatography-UV-Vis detector (HPLC-UV) was successfully developed for extraction and preconcentration of nonsteroidal anti-inflammatory drugs (NSAIDs). The procedure was carried out by adding butyl acetate into the working standard for VALLME step, followed by the back-extraction into sodium hydroxide for further preconcentration and clean-up. Under optimum conditions (NSAIDs concentration; 0.5 μg L−1; volume of sample; 10 mL; pH 3; volume of butyl acetate; 225 μL; vortex time; 105 s; 2250 rpm; back extraction; 20 μL NaOH (0.05 M); vortex speed; 2250 rpm; 60 s). The proposed technique provided good linearity (R2 ≥ 0.9809), repeatability (% RSD 3.4 – 16.1%) with the limit of detection (LOD) and limit of quantification (LOQ) of 0.015 - 0.134 μg L−1 and 0.047 - 0.407 μg L−1, respectively. Under this condition, the enrichment factors for the four NSAIDs were achieved between 219.2 and 379.7-folds. The developed VALLME-BE procedure resulted in a more selective and sensitive technique for the determination of NSAIDs in environmental water samples. |
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Start & End Page |
1363 - 1373 |
Received Date |
2021-01-12 |
Revised Date |
2021-05-07 |
Accepted Date |
2021-05-27 |
Full Text |
Download |
Keyword |
Vortex-assisted liquid-liquid microextraction with back extraction, nonsteroidal anti-inflammatory drugs, high performance liquid chromatography |
Volume |
Vol.48 No.5 (September 2021) |
DOI |
|
Citation |
Mohammad R.,E.,A.,Gubartallah E.,A.,Elbashir A.,A.,Saad B.,Yahaya N.,Zain N.,N.,M., et al., Simultaneous Determination of Nonsteroidal Anti-Inflammatory Drugs Using Vortex-Assisted Liquid-Liquid Microextraction With Back Extraction Coupled With HPLC-UV, Chiang Mai Journal of Science, 2021; 48(5): 1363-1373. |
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