Actinomycins Produced by Streptomyces lichenis LCR6-01T and its Antibacterial Activity
Pawina Kanchanasin, Patcharin Saeng-in, Takuji Nakashima, Hirotaka Matsuo, Yōko Takahashi and Somboon Tanasupawat* Author for corresponding; e-mail address: Somboon.T@chula.ac.th
Volume: Vol.47 No.5 (September 2020)
Research Article
DOI:
Received: 16 April 2020, Revised: -, Accepted: 10 June 2020, Published: -
Citation: Kanchanasin P., Saeng-in P., Nakashima T., Matsuo H., Takahashi Y. and Tanasupawat S., Actinomycins Produced by Streptomyces lichenis LCR6-01T and its Antibacterial Activity, Chiang Mai Journal of Science, 2020; 47(5): 864-871.
Abstract
A new actinomycete species, Streptomyces lichenis LCR6-01T was isolated from lichen collected in Chiang Rai province, Thailand. On the course of screening for antimicrobial activity, the culture broth of strain LCR6-01T exhibited antibacterial activity against Bacillus subtilis ATCC 6633, Kocuria rhizophila ATCC 9341, Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 (inhibition zone 14.7 ± 0.6 - 23.0 ± 0.9 mm). The culture extracts analyzed by liquid chromatographyelectrospray ionization-mass spectrometry (LC-ESI-MS) and the physicochemical properties of secondary metabolites were searched in database. The antibacterial agents were detected as actinomycins which contained 3 analogs of Au7a, D, and D 43β.