Chiang Mai Journal of Science

Insights Into The Causes and Anti-hyperglycemic Effects Of Punica granatum Rind in Alloxan-induced Diabetic Rats

Paper Type	Contributed Paper
Title	Insights Into The Causes and Anti-hyperglycemic Effects Of Punica granatum Rind in Alloxan-induced Diabetic Rats
Author	Sushil Kumar Middha [a,c], Talambedu Usha [b]* and Veena Pande [a]
Email	ushatalambedu@gmail.com
Abstract:  In the present investigation, the anti-hyperglycemic potentialand scientific validation of Punica granatum rind/peel, a waste material and herbal drug,from Kumauni region was assessed in alloxan-induced diabetes model.The effectsof oral administration of different doses i.e low (LP) and high (HP) (LP; 75 mg/kg and HP; 150 mg/kg body weight) of methanolicfragment of P. granatumpeel(PGPE) on blood glucose, lipid peroxidation (MDA; malondialdehyde),antioxidant enzymes (SOD; superoxide dismutase and GPx; glutathione peroxidase) were estimated and compared with glibenclamide and insulin for 45 days.Treatment with PGPE, glibenclamide and insulin resulted in a significant reduction of blood glucoselevels as compared to solvent control (p<0.05).PGPEenhanced the plasma insulin level by five fold. PGPEalso resulted in a significant decrease in MDA values (p>0.001) in kidney (LP; 16.80 and HP; 52.08%) andan increase in antioxidants level (p>0.05) such as SOD 39.68% and 75.03%, GPx 20.07% and 67.60% in plasma and SOD 44% and 66%, GPx 50% and 80% inkidney, though MDA level was not significantly decreased(p<0.05) in plasma, when compared to diabetic controls.Histopathological studies also validated our studies of interest. To conclude, PGPE supplementation leads to an increase in insulin level in experimental animals, confirming restoration of pancreatic b-cells and other parameters clearly indicating the anti-hyperglycemic and antioxidant effect of PGPE.
Start & End Page	112 - 122
Received Date	2013-12-09
Revised Date
Accepted Date	2014-11-17
Full Text	Download
Keyword	Punicagranatum rind, diabetes, alloxan, oxidative stress, antioxidant enzymes, malondialdehyde
Volume	Vol.43 No.1 (JANUARY 2016)
DOI
Citation	Middha S.K., Usha T. and Pande V., Insights Into The Causes and Anti-hyperglycemic Effects Of Punica granatum Rind in Alloxan-induced Diabetic Rats, Chiang Mai J. Sci., 2016; 43(1): 112-122.
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