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Insights Into The Causes and Anti-hyperglycemic Effects Of Punica granatum Rind in Alloxan-induced Diabetic Rats
Paper Type  |
Contributed Paper |
Title |
Insights Into The Causes and Anti-hyperglycemic Effects Of Punica granatum Rind in Alloxan-induced Diabetic Rats |
Author |
Sushil Kumar Middha [a,c], Talambedu Usha [b]* and Veena Pande [a] |
Email |
ushatalambedu@gmail.com |
|
Abstract: In the present investigation, the anti-hyperglycemic potentialand scientific validation of Punica granatum rind/peel, a waste material and herbal drug,from Kumauni region was assessed in alloxan-induced diabetes model.The effectsof oral administration of different doses i.e low (LP) and high (HP) (LP; 75 mg/kg and HP; 150 mg/kg body weight) of methanolicfragment of P. granatumpeel(PGPE) on blood glucose, lipid peroxidation (MDA; malondialdehyde),antioxidant enzymes (SOD; superoxide dismutase and GPx; glutathione peroxidase) were estimated and compared with glibenclamide and insulin for 45 days.Treatment with PGPE, glibenclamide and insulin resulted in a significant reduction of blood glucoselevels as compared to solvent control (p<0.05).PGPEenhanced the plasma insulin level by five fold. PGPEalso resulted in a significant decrease in MDA values (p>0.001) in kidney (LP; 16.80 and HP; 52.08%) andan increase in antioxidants level (p>0.05) such as SOD 39.68% and 75.03%, GPx 20.07% and 67.60% in plasma and SOD 44% and 66%, GPx 50% and 80% inkidney, though MDA level was not significantly decreased(p<0.05) in plasma, when compared to diabetic controls.Histopathological studies also validated our studies of interest. To conclude, PGPE supplementation leads to an increase in insulin level in experimental animals, confirming restoration of pancreatic b-cells and other parameters clearly indicating the anti-hyperglycemic and antioxidant effect of PGPE.
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Start & End Page |
112 - 122 |
Received Date |
2013-12-09 |
Revised Date |
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Accepted Date |
2014-11-17 |
Full Text |
Download |
Keyword |
Punicagranatum rind, diabetes, alloxan, oxidative stress, antioxidant enzymes, malondialdehyde |
Volume |
Vol.43 No.1 (JANUARY 2016) |
DOI |
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Citation |
[a S.K.M., C] , [b]* T.U. and [a] V.P., Insights Into The Causes and Anti-hyperglycemic Effects Of Punica granatum Rind in Alloxan-induced Diabetic Rats, Chiang Mai Journal of Science, 2016; 43(1): 112-122. |
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