Chiang Mai Journal of Science

Synthesis, Characterization and Antioxidant Activity of 2-Halobenzoyl Thiourea bearing α- and β-Alanine

Paper Type	Contributed Paper
Title	Synthesis, Characterization and Antioxidant Activity of 2-Halobenzoyl Thiourea bearing α- and β-Alanine
Author	Nurziana Ngah*, Nor Azanita Mohamed, and Deny Susanti Darnis
Email	nurziana@iium.edu.my
Abstract:  Six new 2-halobenzoylthiourea compounds bearing α- and β-alanine have been successfully synthesized and characterized using CHNS microelemental analysis and spectroscopic methods including FTIR, UV-Vis and NMR. Microelemental analysis data of the compounds were in agreement with the theoretical values. The FTIR spectra showed the presence of important bands of the compounds while the 1H-NMR and 13C-NMR exhibited the expected chemical shifts. The compounds exerted weak antioxidant activity in DPPH scavenging test and moderate to good activity in β-carotene bleaching test. The inclusion of halogen atoms has facilitated the released of hydrogen atoms and introduction of α- and β-alanine have increased the β-carotene bleaching and DPPH scavenging activities of the compounds.
Start & End Page	578 - 584
Received Date	2014-07-14
Revised Date
Accepted Date	2014-10-13
Full Text	Download
Keyword	2-halobenzoyl thiourea, alanine, antioxidant
Volume	Vol.43 No.3 (APRIL 2016)
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