Synthesis, Characterization and Antioxidant Activity of 2-Halobenzoyl Thiourea bearing α- and β-Alanine

Nurziana Ngah; Nor Azanita Mohamed; and Deny Susanti Darnis

Synthesis, Characterization and Antioxidant Activity of 2-Halobenzoyl Thiourea bearing α- and β-Alanine

Nurziana Ngah*, Nor Azanita Mohamed, and Deny Susanti Darnis
* Author for corresponding; e-mail address: nurziana@iium.edu.my
Volume: Vol.43 No.3 (APRIL 2016)
Research Article
DOI:
Received: 14 July 2014, Revised: -, Accepted: 13 October 2014, Published: -

Citation: Ngah N., Mohamed N.A. and Darnis D.S., Synthesis, Characterization and Antioxidant Activity of 2-Halobenzoyl Thiourea bearing α- and β-Alanine, Chiang Mai Journal of Science, 2016; 43(3): 578-584.

Abstract

Six new 2-halobenzoylthiourea compounds bearing α- and β-alanine have been successfully synthesized and characterized using CHNS microelemental analysis and spectroscopic methods including FTIR, UV-Vis and NMR. Microelemental analysis data of the compounds were in agreement with the theoretical values. The FTIR spectra showed the presence of important bands of the compounds while the ¹H-NMR and ¹³C-NMR exhibited the expected chemical shifts. The compounds exerted weak antioxidant activity in DPPH scavenging test and moderate to good activity in β-carotene bleaching test. The inclusion of halogen atoms has facilitated the released of hydrogen atoms and introduction of α- and β-alanine have increased the β-carotene bleaching and DPPH scavenging activities of the compounds.

Keywords: 2-halobenzoyl thiourea, alanine, antioxidant

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