Chiang Mai Journal of Science

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Antitubercular and antimalarial activity-guided study of  the roots of Artocarpus altilis led to the isolation of  nine prenylated flavones. Cycloartocarpin (1), artocarpin (2), and chaplashin (3) were isolated from the dichloromethane extract of the root stems, whereas morusin (4), cudraflavone B (5), cycloartobiloxanthone (6), artonin E (7), cudraflavone C (8) and artobiloxanthone (9) were found in the root barks. The isolated compounds exhibited antitubercular and antiplasmodial activities, and also showed moderate cytotoxicity against KB (human oral epidermoid carcinoma) and BC (human breast cancer) cell lines.

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