Antitubercular and Antiplasmodial Prenylated Flavones from the Roots of Artocarpus altilis
Surat Boonphong , Apiwat Baramee, Prasat Kittakoop , and Pakawan Puangsombat* Author for corresponding; e-mail address: pakawan@science.cmu.ac.th
Volume: Vol.34 No.3 (SEPTEMBER 2007)
Research Article
DOI:
Received: 3 May 2007, Revised: -, Accepted: 23 May 2007, Published: -
Citation: Boonphong S., Baramee A., Kittakoop P. and Puangsombat P., Antitubercular and Antiplasmodial Prenylated Flavones from the Roots of Artocarpus altilis, Chiang Mai Journal of Science, 2007; 34(3): 339-344.
Abstract
Antitubercular and antimalarial activity-guided study of the roots of Artocarpus altilis led to the isolation of nine prenylated flavones. Cycloartocarpin (1), artocarpin (2), and chaplashin (3) were isolated from the dichloromethane extract of the root stems, whereas morusin (4), cudraflavone B (5), cycloartobiloxanthone (6), artonin E (7), cudraflavone C (8) and artobiloxanthone (9) were found in the root barks. The isolated compounds exhibited antitubercular and antiplasmodial activities, and also showed moderate cytotoxicity against KB (human oral epidermoid carcinoma) and BC (human breast cancer) cell lines.