Chiang Mai Journal of Science

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Activity-guided investigation of Vitex trifolia (Verbenaceae) has led to the isolation of heptatriacontane (1), a -pinene (2) and (4R,5R)-caryophyllene-oxide (3). The structural elucidation of these compounds was based upon the basis of spectroscopic analysis. These compounds exhibited EC₅₀ values in the range of 10-100x10^-6g/mL against Plasmodium falciparum (K1, multidrug resistant strain) in vitro. More particularly, compound (3), a tentative sesquiterpene antimalarial, exhibited a rather high potency against the parasites among the compounds (1) and (2), which were isolated in this research.

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