Antimalarial Activity in Vitro of Some Natural Extracts from Vitex trifolia
Sombat Chowwanapoonpohn and Apiwat Baramee* Author for corresponding; e-mail address: -
Volume: Vol.27 No.1 (JUNE 2000)
Opinion
DOI:
Received: 15 August 1999, Revised: -, Accepted: 23 December 1999, Published: -
Citation: Chowwanapoonpohn S. and Baramee A., Antimalarial Activity in Vitro of Some Natural Extracts from Vitex trifolia, Chiang Mai Journal of Science, 2000; 27(1): 9-13.
Abstract
Activity-guided investigation of Vitex trifolia (Verbenaceae) has led to the isolation of heptatriacontane (1), a -pinene (2) and (4R,5R)-caryophyllene-oxide (3). The structural elucidation of these compounds was based upon the basis of spectroscopic analysis. These compounds exhibited EC50 values in the range of 10-100x10-6g/mL against Plasmodium falciparum (K1, multidrug resistant strain) in vitro. More particularly, compound (3), a tentative sesquiterpene antimalarial, exhibited a rather high potency against the parasites among the compounds (1) and (2), which were isolated in this research.