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Antimalarial Activity in Vitro of Some Natural Extracts from Vitex trifolia
Paper Type  |
Opinion |
Title |
Antimalarial Activity in Vitro of Some Natural Extracts from Vitex trifolia |
Author |
Sombat Chowwanapoonpohn and Apiwat Baramee |
Email |
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Abstract: Activity-guided investigation of Vitex trifolia (Verbenaceae) has led to the isolation of heptatriacontane (1), a -pinene (2) and (4R,5R)-caryophyllene-oxide (3). The structural elucidation of these compounds was based upon the basis of spectroscopic analysis. These compounds exhibited EC50 values in the range of 10-100x10-6g/mL against Plasmodium falciparum (K1, multidrug resistant strain) in vitro. More particularly, compound (3), a tentative sesquiterpene antimalarial, exhibited a rather high potency against the parasites among the compounds (1) and (2), which were isolated in this research.
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Start & End Page |
9 - 13 |
Received Date |
1999-08-15 |
Revised Date |
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Accepted Date |
1999-12-23 |
Full Text |
Download |
Keyword |
Vitex trifolia, antimalarial |
Volume |
Vol.27 No.1 (JUNE 2000) |
DOI |
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Citation |
Chowwanapoonpohn S. and Baramee A., Antimalarial Activity in Vitro of Some Natural Extracts from Vitex trifolia, Chiang Mai J. Sci., 2000; 27(1): 9-13. |
SDGs |
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