Chiang Mai Journal of Science

     Ganoderma has attracted significant scientific interest due to its extensive range of therapeutic properties. The bioactive compounds in Ganoderma, including polysaccharides, triterpenoids, steroids, phenols, and proteins, play crucial roles in its pharmacological effects. These compounds interact synergistically to exert various biological activities. In the management of diabetes, Ganoderma has been shown to enhance insulin sensitivity, modulate glucose metabolism, and reduce oxidative stress. These actions collectively contribute to the improvement of hyperglycemia and its associated complications. The polysaccharides in Ganoderma, particularly β-glucans, have been shown to improve pancreatic function and enhance insulin secretion. Triterpenoids and phenolic compounds also possess potent antioxidant properties that mitigate oxidative damage in diabetic conditions. This review synthesizes current research findings from both in vitro and in vivo studies, providing a detailed analysis of the therapeutic potential of Ganoderma in diabetes management. The anti-diabetic activities of Ganoderma are discussed in the context of molecular pathways and biochemical interactions. Furthermore, the review highlights the importance of dosage, administration routes, and the synergistic effects of bioactive compounds in Ganoderma. However, despite the promising therapeutic potential of Ganoderma, further research is necessary to fully understand its mechanisms of action and establish standardized protocols for its clinical use. The need for future studies, focusing on large-scale clinical trials, identifying specific bioactive compounds, and exploring the effects of Ganoderma on various disease models, is crucial to bridging the gap between traditional use and modern scientific validation, highlighting its potential as a natural therapeutic agent for diabetes.