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Anti-gastric ulcer and acute oral toxicity of aqueous extract of Turbinaria conoides from the Gulf of Thailand
Paper Type  |
Contributed Paper |
Title |
Anti-gastric ulcer and acute oral toxicity of aqueous extract of Turbinaria conoides from the Gulf of Thailand |
Author |
Walailuck Boonchum[a], Panmuk Vacharapiyasophon[a], Duangta Kanjanapothi[b], Jeeraporn Pekkoh[a], Do |
Email |
scboi017@chiangmai.ac.th |
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Abstract:
Turbinaria conoides is a brown marine alga which was collected from the Gulf Thailand. In previous studies, aqueous extract (AE) of T. conoides have shown a potential in performing beneficial activities, including antioxidative, antimicrobial and anti-inflammatory activities. In this report, the potential of T. conoides as a protectant against gastric ulcers resulting from restraint water immersion stress, mixture of HCl/ethanol and indomethacin induced gastric ulcer in rats were studied. AE of T. conoides could reduce gastric ulceration in all assays in the range of 50.98 – 99.85 %. The highest activity was found in the HCl/ethanol model. Moreover, AE of T. conoides has non-oral toxicity in high dose. These results suggest that the AE of T. conoides could help protect the stomach from stress, indomethacin as well as HCl/ethanol induced gastric ulcers. Its safety as a neutraceutical or pharmaceutical product has also been determined.
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Start & End Page |
292 - 299 |
Received Date |
2011-05-11 |
Revised Date |
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Accepted Date |
2011-08-08 |
Full Text |
Download |
Keyword |
gastroprotective activity, gastric ulcer, indomethacin, HCl/ethanol, restraint water immersion stress |
Volume |
Vol.39 No.2 (APRIL 2012) |
DOI |
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Citation |
Boonchum[a] W., Vacharapiyasophon[a] P., Kanjanapothi[b] D., Pekkoh[a] J. and Do , Anti-gastric ulcer and acute oral toxicity of aqueous extract of Turbinaria conoides from the Gulf of Thailand, Chiang Mai Journal of Science, 2012; 39(2): 292-299. |
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