Anti-gastric ulcer and acute oral toxicity of aqueous extract of Turbinaria conoides from the Gulf of Thailand
Walailuck Boonchum[a], Panmuk Vacharapiyasophon[a], Duangta Kanjanapothi[b], Jeeraporn Pekkoh[a], Do* Author for corresponding; e-mail address: scboi017@chiangmai.ac.th
Volume: Vol.39 No.2 (APRIL 2012)
Research Article
DOI:
Received: 11 May 2011, Revised: -, Accepted: 8 August 2011, Published: -
Citation: Boonchum W., Vacharapiyasophon P., Kanjanapothi D., Pekkoh J. and Do , Anti-gastric ulcer and acute oral toxicity of aqueous extract of Turbinaria conoides from the Gulf of Thailand, Chiang Mai Journal of Science, 2012; 39(2): 292-299.
Abstract
Turbinaria conoides is a brown marine alga which was collected from the Gulf Thailand. In previous studies, aqueous extract (AE) of T. conoides have shown a potential in performing beneficial activities, including antioxidative, antimicrobial and anti-inflammatory activities. In this report, the potential of T. conoides as a protectant against gastric ulcers resulting from restraint water immersion stress, mixture of HCl/ethanol and indomethacin induced gastric ulcer in rats were studied. AE of T. conoides could reduce gastric ulceration in all assays in the range of 50.98 – 99.85 %. The highest activity was found in the HCl/ethanol model. Moreover, AE of T. conoides has non-oral toxicity in high dose. These results suggest that the AE of T. conoides could help protect the stomach from stress, indomethacin as well as HCl/ethanol induced gastric ulcers. Its safety as a neutraceutical or pharmaceutical product has also been determined.