Synthesis of (+/-) 3-Acetoxy-2-methylene-4-cyclopentenone, Pentenomycin II and Epipentenomycin II Precursors

Theeraphan Machan; Apiwat Baramee

Synthesis of (+/-) 3-Acetoxy-2-methylene-4-cyclopentenone, Pentenomycin II and Epipentenomycin II Precursors

Theeraphan Machan and Apiwat Baramee*
* Author for corresponding; e-mail address: chlapiba@science.cmu.ac.th
Volume: Vol.30 No.1 (APRIL 2003)
Research Article
DOI:
Received: 27 November 2002, Revised: -, Accepted: 19 March 2003, Published: -

Citation: Machan T. and Baramee A., Synthesis of (+/-) 3-Acetoxy-2-methylene-4-cyclopentenone, Pentenomycin II and Epipentenomycin II Precursors, Chiang Mai Journal of Science, 2003; 30(1): 41-45.

Abstract

A two steps synthesis of (+) 3-acetoxy-2-methylene-4-cyclopentenone was achieved, starting from epoxy-2-methylenecyclopentanone anthracene adduct. The key reaction involved flash vacuum pyrolysis of epoxy-2-methylenecyclopentanone anthracene adduct and acetylation of the resulting product.

Keywords: cyclopentenones, pentenomycin, epipentenomycin, synthesis

Chiang Mai Journal of Science

1,647

Q3 0.80

Q3 1.3

7 days

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