Paper Type |
Contributed Paper |
Title |
Analytical Validation of Sildenafil Citrate Inhaler Preparation |
Author |
Somchai Sawatdee [a] and Teerapol Srichana* [a,b] |
Email |
teerapol.s@psu.ac.th |
Abstract: The aim of this study was to develop and validate a high performance liquid chromatographic (HPLC) system for the analysis of sildenafil citrate in pharmaceutical inhaler preparations. Sildenafil was partially degraded by acid and alkali and was completely degraded by oxidation. Direct exposure to heat and UV in solid state had no effect on the degradation of sildenafil. This method was able to resolve any degradation products from the sildenafil peak. Sildenafil citrate showed UV absorption maximum at 240 and 276 nm. A reversed phase HPLC system for the separation and quantitation of sildenafil citrate assay was successfully developed and validated. The chromatographic conditions employed a C18 column (4.6 x |
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Start & End Page |
669 - 680 |
Received Date |
2012-12-13 |
Revised Date |
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Accepted Date |
2013-02-15 |
Full Text |
Download |
Keyword |
sildenafil citrate, validation, liquid chromatography, degradation |
Volume |
Vol.40 No.4 (OCTOBER 2013) |
DOI |
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Citation |
Sawatdee S. and Srichana T., Analytical Validation of Sildenafil Citrate Inhaler Preparation, Chiang Mai J. Sci., 2013; 40(4): 669-680. |
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