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Synthesis and evaluation of anti-tuberculosis and anti-cancer activities of hydroxynaphthoquinone derivatives
Paper Type  |
Contributed Paper |
Title |
Synthesis and evaluation of anti-tuberculosis and anti-cancer activities of hydroxynaphthoquinone derivatives |
Author |
Wanthani Paengsri*[a] and Apiwat Baramee [a] |
Email |
Wanthani Paengsri*[a] and Apiwat Baramee [a] |
|
Abstract: Hydroxy-1,4-naphthoquinone derivatives associated with a variety of side chains have been synthesized from 2-hydroxy-1,4-naphthoquinone 1, butylamine, allylamine and selected aldehydes. Their biologically significant activities, anti-mycobacterium tuberculosis (H37Ra strain), anti-cancer (MCF7-breast cancer and NCI-H187-small cell lung cancer) were studied and reported. It was found that (2E,4E)-1,4-dioxo-1,4-dihydronaphthalen-2-yl-5(benzo[d][1,3]dioxol-5-yl)penta-2,4-dienoate 6 showed significant anti-MCF7 and anti-NCI-H187 activities with IC50 value at 3.84 µg/mL and 2.24 µg/mL and was found non-cytotoxic. In addition, 2-((allylamino)(phenyl)methyl)-3-hydroxynaphthalene-1,4-dione 2f also showed similar bioactivities to those of compound 6 and it showed anti-TB activity with MIC value 25 µg/mL however it was found to display cytotoxic activity against Vero cells. |
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Start & End Page |
70 - 76 |
Received Date |
2011-08-30 |
Revised Date |
|
Accepted Date |
2012-08-09 |
Full Text |
Download |
Keyword |
naphthoquinone, hydroxy-1, 4-naphthoquinone, anti-tuberculosis, anti-cancer |
Volume |
Vol.40 No.1 (JANUARY 2013) |
DOI |
|
Citation |
Paengsri*[a] W. and [a] A.B., Synthesis and evaluation of anti-tuberculosis and anti-cancer activities of hydroxynaphthoquinone derivatives, Chiang Mai Journal of Science, 2013; 40(1): 70-76. |
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