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Chiang Mai Journal of Science, Faculty of Science, Chiang Mai University
 


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Green Synthesis of Bis(indolyl)methanes Catalysed by Salicylic Acid


Paper Type 
Contributed Paper
Title 
Green Synthesis of Bis(indolyl)methanes Catalysed by Salicylic Acid
Author 
Hoda Banari, Hamzeh Kiyani and Alireza Pourali
Email 
hkiyani@du.ac.ir
Abstract:
In this contribution, salicylic acid (SA) has been used to catalyze synthesis of a series of biologically relevant 3,3¢-bis(indolyl)methanes (BIMs) via the electrophilic substitution of indole derivatives on aldehyde compounds. The optimum catalyst loading was observed at 15 mol%. The procedure is simple and the expected bis-heterocyclic compounds were isolated in good to high yields. The present protocol provides the advantages of convenience, mild reaction conditions, eco-friendliness, energy-saving, and no use of hazardous solvents.
Start & End Page 
413 - 420
Received Date 
2016-03-01
Revised Date 
Accepted Date 
2016-05-10
Full Text 
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Keyword 
3,3¢-bis(indolyl)methanes, salicylic acid, indole, 2-methylindole, green
Volume 
Vol.45 No.1 (January 2018)
DOI 
Citation 
Banari H., Kiyani H. and Pourali A., Green Synthesis of Bis(indolyl)methanes Catalysed by Salicylic Acid, Chiang Mai Journal of Science, 2018; 45(1): 413-420.
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