Chiang Mai Journal of Science

Print ISSN: 0125-2526 | eISSN : 2465-3845

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Green Synthesis of Bis(indolyl)methanes Catalysed by Salicylic Acid

Hoda Banari, Hamzeh Kiyani and Alireza Pourali
* Author for corresponding; e-mail address: hkiyani@du.ac.ir
Volume: Vol.45 No.1 (January 2018)
Research Article
DOI:
Received: 1 March 2016, Revised: -, Accepted: 10 May 2016, Published: -

Citation: Banari H., Kiyani H. and Pourali A., Green Synthesis of Bis(indolyl)methanes Catalysed by Salicylic Acid, Chiang Mai Journal of Science, 2018; 45(1): 413-420.

Abstract

In this contribution, salicylic acid (SA) has been used to catalyze synthesis of a series of biologically relevant 3,3¢-bis(indolyl)methanes (BIMs) via the electrophilic substitution of indole derivatives on aldehyde compounds. The optimum catalyst loading was observed at 15 mol%. The procedure is simple and the expected bis-heterocyclic compounds were isolated in good to high yields. The present protocol provides the advantages of convenience, mild reaction conditions, eco-friendliness, energy-saving, and no use of hazardous solvents.

Keywords: 3,3¢-bis(indolyl)methanes, salicylic acid, indole, 2-methylindole, green

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