An Expeditious and Green Synthesis of 3,3¢-(Arylmethylene)-bis-(4-hydroxycoumarins) Catalyzed by 5-Sulfosalicylic Acid
Hamzeh Kiyani* and Hassan Darbandi* Author for corresponding; e-mail address: hkiyani@du.ac.ir
Volume: Vol.44 No.3 (July 2017)
Research Article
DOI:
Received: 12 June 2015, Revised: -, Accepted: 4 September 2015, Published: -
Citation: Kiyani H. and Darbandi H., An Expeditious and Green Synthesis of 3,3¢-(Arylmethylene)-bis-(4-hydroxycoumarins) Catalyzed by 5-Sulfosalicylic Acid , Chiang Mai Journal of Science, 2017; 44(3): 1002-1010.
Abstract
The expeditious synthesis of 3,3¢-(arylmethylene)-bis-(4-hydroxycoumarins) via a three-component domino Knoevenagel-Michael reaction (3CDKMR) of various aldehydes and 4-hydroxycoumarin, catalyzed by 5-sulfosalicylic acid (SA) is explored. The reactions were conducted at 80 °C using water as a green and environmentally benign medium. The method has several advantages such as reusability of reaction medium, the avoidance of hazardous organic solvents, readily available reagents, cost-effectiveness, and good to high yields.