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Chiang Mai Journal of Science, Faculty of Science, Chiang Mai University
 


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Nickel-catalyzed One-pot, Three-component Synthesis of 3,4-Disubstituted Isoxazole-5(4H)-ones in Aqueous Medium


Paper Type 
Contributed Paper
Title 
Nickel-catalyzed One-pot, Three-component Synthesis of 3,4-Disubstituted Isoxazole-5(4H)-ones in Aqueous Medium
Author 
Hamzeh Kiyani* and Heshmat Allah Samimi
Email 
hkiyani@du.ac.ir
Abstract:
An efficient and simple cyclocondensation approach for the one-pot, three-component synthesis of 3,4-disubtituted isoxazole-5(4H)-ones has been described. This three-component reaction was completed easily and cleanly to give corresponding isoxazoles in the presence of Ni(OAc)2.H2O as the catalyst. The reaction was implemented in aqueous media at room temoerature and the corresponding heterocyclic were obtained in good to high yields. The present work offers notable advantages, including easy work-up, simple procedure, mild condition, and no use of organic solvents.
Start & End Page 
1011 - 1021
Received Date 
2015-03-13
Revised Date 
Accepted Date 
2015-05-17
Full Text 
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Keyword 
3,4-disubstituted isoxazole-5(4H)-ones, Ni(OAc)2.H2O, water, three-component synthesis, B-oxoesters
Volume 
Vol.44 No.3 (July 2017)
DOI 
Citation 
Kiyani* H. and Samimi H.A., Nickel-catalyzed One-pot, Three-component Synthesis of 3,4-Disubstituted Isoxazole-5(4H)-ones in Aqueous Medium, Chiang Mai Journal of Science, 2017; 44(3): 1011-1021.
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Benthic Macroinvertebrates Diversity and Water Quality of Some Main Wetlands in Chiang Mai-Lamphun Basin
page: 102 - 113
Author:Weerasak Roongruangwongse [a], Pongpor Asnachinda [b] and Wanchai Sonthichai [a]
Vol.27 No.2 (DECEMBER 2000) View: 694 Download:196
Population Dynamics of the Green-Lipped Mussel, Perna viridis from the Offshore Waters of Naf River Coast, Bangladesh
page: 344 - 354
Author:Mohammed A.A. Khan, Zaini B. Assim, and Norhadi Ismail
Vol.37 No.2 (MAY 2010) View: 725 Download:248



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