Nickel-catalyzed One-pot, Three-component Synthesis of 3,4-Disubstituted Isoxazole-5(4H)-ones in Aqueous Medium
Hamzeh Kiyani* and Heshmat Allah Samimi* Author for corresponding; e-mail address: hkiyani@du.ac.ir
Volume: Vol.44 No.3 (July 2017)
Research Article
DOI:
Received: 13 March 2015, Revised: -, Accepted: 17 May 2015, Published: -
Citation: Kiyani H. and Samimi H.A., Nickel-catalyzed One-pot, Three-component Synthesis of 3,4-Disubstituted Isoxazole-5(4H)-ones in Aqueous Medium, Chiang Mai Journal of Science, 2017; 44(3): 1011-1021.
Abstract
An efficient and simple cyclocondensation approach for the one-pot, three-component synthesis of 3,4-disubtituted isoxazole-5(4H)-ones has been described. This three-component reaction was completed easily and cleanly to give corresponding isoxazoles in the presence of Ni(OAc)2.H2O as the catalyst. The reaction was implemented in aqueous media at room temoerature and the corresponding heterocyclic were obtained in good to high yields. The present work offers notable advantages, including easy work-up, simple procedure, mild condition, and no use of organic solvents.