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Nickel-catalyzed One-pot, Three-component Synthesis of 3,4-Disubstituted Isoxazole-5(4H)-ones in Aqueous Medium


Paper Type 
 Contributed Paper
Title 
 Nickel-catalyzed One-pot, Three-component Synthesis of 3,4-Disubstituted Isoxazole-5(4H)-ones in Aqueous Medium
Author 
 Hamzeh Kiyani* and Heshmat Allah Samimi
Email 
 hkiyani@du.ac.ir
Abstract:
An efficient and simple cyclocondensation approach for the one-pot, three-component synthesis of 3,4-disubtituted isoxazole-5(4H)-ones has been described. This three-component reaction was completed easily and cleanly to give corresponding isoxazoles in the presence of Ni(OAc)2.H2O as the catalyst. The reaction was implemented in aqueous media at room temoerature and the corresponding heterocyclic were obtained in good to high yields. The present work offers notable advantages, including easy work-up, simple procedure, mild condition, and no use of organic solvents.
Start & End Page 
 1011 - 1021
Received Date 
 2015-03-13
Revised Date 
Accepted Date 
 2015-05-17
Full Text 
   Download
Keyword 
 3,4-disubstituted isoxazole-5(4H)-ones, Ni(OAc)2.H2O, water, three-component synthesis, B-oxoesters
Volume 
 Vol.44 No.3 (July 2017)
DOI 
Citation 
 Kiyani* H. and Samimi H.A., Nickel-catalyzed One-pot, Three-component Synthesis of 3,4-Disubstituted Isoxazole-5(4H)-ones in Aqueous Medium, Chiang Mai Journal of Science, 2017; 44(3): 1011-1021.
View:865 Download:291

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Author:Jaroon Junsomboon, Ponlayuth Sooksamiti, Kate Grudpan, Somchai Lapanantnoppakhun, Prasak Thavornyuth
Vol.36 No.3 (SEPTEMBER 2009) View: 786 Download:215
Calculation of Weighted Averages Approach for the Estimation of Ping Tolerance Values
page: 151 - 159
Author:Somyot Silalom, James L. Carter, and Porntip Chantaramongkol
Vol.37 No.1 (JANUARY 2010) View: 769 Download:211
Aggregation and Pedogenesis of Seasonally Inundated Soils of a Tropical Watershed
page: 74 - 84
Author:Emmanuel U. Onweremadu, Ogochukwu P. Izuogu, and Frank O.R. Akamigbo
Vol.37 No.1 (JANUARY 2010) View: 808 Download:275
Concentrations of Arsenic in Water, Soil, Hair, and Biological Samples in Hizla, Bangladesh
page: 7 - 13
Author:Abu Sayed Md. Kamal* and Preeda Parkpian
Vol.29 No.1 (APRIL 2002) View: 801 Download:284
Fifty One New Record Species of Freshwater Diatoms in Thailand
page: 97 - 112
Author:Trai Pekthong and Yuwadee Peerapornpisal
Vol.28 No.2 (DECEMBER 2001) View: 778 Download:244
Solid Phase Extraction of Carbamate and Organochlorine Pesticides in Water
page: 9 - 15
Author:Wanna Kanchanamayoon, Sirichai Hathongkam and Amnat Laothong
Vol.28 No.1 (JUNE 2001) View: 773 Download:420
Benthic Macroinvertebrates Diversity and Water Quality of Some Main Wetlands in Chiang Mai-Lamphun Basin
page: 102 - 113
Author:Weerasak Roongruangwongse [a], Pongpor Asnachinda [b] and Wanchai Sonthichai [a]
Vol.27 No.2 (DECEMBER 2000) View: 797 Download:220
Population Dynamics of the Green-Lipped Mussel, Perna viridis from the Offshore Waters of Naf River Coast, Bangladesh
page: 344 - 354
Author:Mohammed A.A. Khan, Zaini B. Assim, and Norhadi Ismail
Vol.37 No.2 (MAY 2010) View: 834 Download:291



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