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Hepatotoxin Biosynthesis and Regulation in Cyanobacteria – the Putative Involvement of Nitrogen and Iron Homeostasis Mechanisms


Paper Type 
Short Communication
Title 
Hepatotoxin Biosynthesis and Regulation in Cyanobacteria – the Putative Involvement of Nitrogen and Iron Homeostasis Mechanisms
Author 
Hannah P. Ginn, Leanne A. Pearson and Brett A. Neilan
Email 
b.neilan@unsw.edu.au
Abstract:
Cyanobacteria are recognised globally as a human health threat due to their proliferation into toxic blooms. Of particular concern are strains that produce the hepatotoxins, microcystin and nodularin. Research over the past decade has revealed the biochemical and molecular mechanisms behind hepatotoxin production. However, there is still much to learn regarding the regulation of these biologically active metabolites. This review provides an overview of cyanobacterial hepatotoxin research to date and additionally, elaborates on the putative involvement of nitrogen and iron homeostatic mechanisms in cyanotoxin regulation.
Start & End Page 
200 - 223
Received Date 
Revised Date 
Accepted Date 
Full Text 
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Keyword 
Cyanobacteria, microcystin, nodularin, iron stress, nitrogen stress, NtcA, Fur, non-ribosomal peptide, polyketide, regulation
Volume 
Vol.36 No.2 (MAY 2009)
DOI 
Citation 
Ginn H.P., Pearson L.A. and Neilan B.A., Hepatotoxin Biosynthesis and Regulation in Cyanobacteria – the Putative Involvement of Nitrogen and Iron Homeostasis Mechanisms, Chiang Mai Journal of Science, 2009; 36(2): 200-223.
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