Chiang Mai Journal of Science

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The biological activities of crude extracts of Chromolaena odorata, collected from Thapho, Muang district, Phitsanulok Province, Thailand were investigated. It is evident that, the DCM/water extract of the aerial part of the plant (fraction EU9C) showed potent anti-HSV-1 activity (IC₅₀ = 1.74¹/4g/mL) and also showed moderate activity against Mycobacterium tuberculosis in vitro. The anti malarial activity against Plasmodium falciparum K1 strain with the EC₅₀  of 9.39¹/4g/mL has been pioneered in the DCM/water extract of the subterranean part of this plant (fraction EU10C). Only fraction EU9B showed anti-inflammatory activity. The essential oil of the aerial parts also showed antibacterial activity against Staphylococcus aureus and Escherichia coli. The chemical constituents of the aerial part extract were also investigated after separation and purification. Six flavonoids were obtained in which three of them were isolated from this plant for the first time including 3,5,4′-trihydroxy-7-methoxyflavanone; 5,7,3 trihydroxy-5′- methoxyflavanone and 3,5,7-trihydroxy-4′-methoxyflavanone. Further investigation will be made to find out some new bioactive compounds which may be useful for drug development.

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