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Optimization of Solid-state Fermentation for Fruiting Body Growth and Cordecepin Production by Cordyceps militaris


Paper Type 
 Contributed Paper
Title 
 Optimization of Solid-state Fermentation for Fruiting Body Growth and Cordecepin Production by Cordyceps militaris
Author 
 Ting-chi Wen, Cuang-rong Li, Ji-chuan Kang*,Chao Kang and Kevin D. Hyde
Email 
 bcec.jckang@gzu.edu.cn
Abstract:

 Cordyceps militaris has traditionally been used in Traditional Chinese Medicine, however C. militaris has gained importance and is also used as a FUNCTIONAL FOOD. Cordyceps militaris contains similar biochemical components as C. sinensis as well as the anti-cancer component cordycepin. Because C. militaris can be grown in culture and has significant medicinal affects, market demand for artificial C. militaris has increased. This study was aimed to optimize the conditions of solid-state fermentation for fruiting body growth and cordycepin production frome C. militaris by one-factor-at-a-time and orthogonal layout methods. The optimal culture substate was brown rice. The optimal fruiting body growth and cordycepin production were observed at relatively low pH value. The optimum composition were 40 g/L glucose, 5 g/L peptone, 1.5 g/L MgSO4.7H2O, 1.5 g/L K2HPO4 and 1.0 mg/L NAA for optimal fruiting body growth and 10 g/L NAA for cordycepin production. These optimization strategies in solid medium culture lead to a 67.96% (1.73±0.08 g/bottle) increase in fruiting body yield and a 63.17% (9.17±0.09 mg/g) increase of cordecepin yield in fruiting body, which may be applied in industrial production of cordycepin via solid-state fermentation.
Start & End Page 
 858 - 872
Received Date 
 2013-12-15
Revised Date 
Accepted Date 
 2014-02-17
Full Text 
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Keyword 
 Cordyceps militaris , solid-state fermentation, fruiting-body, cordycepin, optimization
Volume 
 Vol.41 No.4 (SPECIAL ISSUE 1)
DOI 
Citation 
 Wen T., Li C., Kang* J., Kang C. and Hyde K.D., Optimization of Solid-state Fermentation for Fruiting Body Growth and Cordecepin Production by Cordyceps militaris, Chiang Mai Journal of Science, 2014; 41(4): 858-872.
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