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Assessment of the Anti-inflammatory Activity of Piceatannol-rich Extract from Senna garrettiana Heartwood
Paper Type  |
Contributed Paper |
Title |
Assessment of the Anti-inflammatory Activity of Piceatannol-rich Extract from Senna garrettiana Heartwood |
Author |
Suparada Surapanthanakorn, Chatchai Wattanapiromsakul and Wantana Reanmongkol |
Email |
wantana.r@psu.ac.th |
|
Abstract: Senna garrettiana (F. Caesalpiniaceae) is a Thai medicinal plant. Its heartwood is a rich source of piceatannol. In the present study, piceatannol-rich extract (PRE) from S. garrettiana containing 39.2% w/w piceatannol was investigated on inflammatory models in rodents. Topical application (2-8 mg/ear) of the PRE inhibited croton oil-induced mouse ear swelling with a maximal suppression of 45.85% and reduced myeloperoxidase activity by 30.21%. Oral administration of the PRE (10-40 mg/kg) dose-dependently produced a significant suppression of rat paw swelling with 75.81% maximal inhibition at 4 h. The PRE (40 mg/kg) decreased the granuloma weight and attenuated joint swelling at day 13 by 27.93% and 69.25%, respectively. The PRE (40 mg/kg) also suppressed the production of PGE2, TNF-a and IL-1b in the Complete Freund’s adjuvant-injected paw to levels comparable with indomethacin (5 mg/kg). These results demonstrated that the PRE possessed anti-inflammatory effect, and its action might be attributed to inhibition of leukocyte infiltration, as well as modulating the production of PGE2 and pro-inflammatory cytokines, TNF-a and IL-1b. |
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Start & End Page |
2691 - 2702 |
Received Date |
2018-04-09 |
Revised Date |
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Accepted Date |
2018-06-25 |
Full Text |
Download |
Keyword |
arthritis, ear edema, inflammation, paw swelling, Senna garrettiana |
Volume |
Vol.45 NO.7 (November 2018) |
DOI |
|
Citation |
Surapanthanakorn S., Wattanapiromsakul C. and Reanmongkol W., Assessment of the Anti-inflammatory Activity of Piceatannol-rich Extract from Senna garrettiana Heartwood, Chiang Mai Journal of Science, 2018; 45(7): 2691-2702. |
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