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Co-precipitation of Mefenamic acid and Polyethylene Glycol 4000 Using the Gas Anti-Solvent (GAS) Process
Paper Type  |
Contributed Paper |
Title |
Co-precipitation of Mefenamic acid and Polyethylene Glycol 4000 Using the Gas Anti-Solvent (GAS) Process |
Author |
Manop Charoenchaitrakool *[a, b], Siwaporn Suttikornchai [a, b] and Thitima Songjitsomboon [a] |
Email |
manop.c@ku.ac.th |
|
Abstract: Production of composites of mefenamic acid (MEF) and polyethylene glycol the highest % drug loading (22.83%) was achieved. A reduction in temperature or an increase in drug and polymer concentration yielded slightly smaller size of composite particles. In addition, it was found that the composites exhibited a higher dissolution rate than the MEF precipitated by the GAS process and could dissolve completely within 3 hours. However, the dissolution rate of the composites was lower than that of the physical mixture of MEF and PEG 4000. This could be attributed to the larger particle sizes of the composites compared to those of the physical mixture, less efficient wetting and lower degree of powder dispersion by PEG in the composites. |
|
Start & End Page |
440 - 446 |
Received Date |
2011-10-20 |
Revised Date |
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Accepted Date |
|
Full Text |
Download |
Keyword |
GAS process, pharmaceutical products, supercritical fluids, composite materials, mefenamic acid, PEG |
Volume |
Vol.40 No.3 (JULY 2013) |
DOI |
|
Citation |
[a M.C., B] , [a S.S.., B] and Songjitsomboon T., Co-precipitation of Mefenamic acid and Polyethylene Glycol 4000 Using the Gas Anti-Solvent (GAS) Process, Chiang Mai J. Sci., 2013; 40(3): 440-446. |
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