Journal Volumes
Visitors
ALL : 2,095,431
TODAY : 3,775
ONLINE : 274
ALL : 2,095,431
TODAY : 3,775
ONLINE : 274
Submit your paper 
Download Template JOURNAL DETAIL
Co-precipitation of Mefenamic acid and Polyethylene Glycol 4000 Using the Gas Anti-Solvent (GAS) Process
Paper Type  |
Contributed Paper |
Title |
Co-precipitation of Mefenamic acid and Polyethylene Glycol 4000 Using the Gas Anti-Solvent (GAS) Process |
Author |
Manop Charoenchaitrakool *[a, b], Siwaporn Suttikornchai [a, b] and Thitima Songjitsomboon [a] |
Email |
manop.c@ku.ac.th |
|
Abstract: Production of composites of mefenamic acid (MEF) and polyethylene glycol the highest % drug loading (22.83%) was achieved. A reduction in temperature or an increase in drug and polymer concentration yielded slightly smaller size of composite particles. In addition, it was found that the composites exhibited a higher dissolution rate than the MEF precipitated by the GAS process and could dissolve completely within 3 hours. However, the dissolution rate of the composites was lower than that of the physical mixture of MEF and PEG 4000. This could be attributed to the larger particle sizes of the composites compared to those of the physical mixture, less efficient wetting and lower degree of powder dispersion by PEG in the composites. |
|
Start & End Page |
440 - 446 |
Received Date |
2011-10-20 |
Revised Date |
|
Accepted Date |
|
Full Text |
Download |
Keyword |
GAS process, pharmaceutical products, supercritical fluids, composite materials, mefenamic acid, PEG |
Volume |
Vol.40 No.3 (JULY 2013) |
DOI |
|
Citation |
[a M.C., B] , [a S.S.., B] and Songjitsomboon T., Co-precipitation of Mefenamic acid and Polyethylene Glycol 4000 Using the Gas Anti-Solvent (GAS) Process, Chiang Mai J. Sci., 2013; 40(3): 440-446. |
SDGs |
|
| View:529 Download:167 | |
RELATED ARTICLE
In Vitro Selection of Mungbean Genotypes for Drought Tolerance by Polyethylene Glycol Induced Water Deficit
Article ID: e2023035
Author:Chadapon Chaiyapan, Apinya Khairum, Witsarut Chueakhunthod, Pakhawat Pookhamsak, Ketwalee Siwapithakpong and Piyada A. Tantasawat
Vol.50 No.3 (May 2023) View: 471 Download:300
Article ID: e2023035
Author:Chadapon Chaiyapan, Apinya Khairum, Witsarut Chueakhunthod, Pakhawat Pookhamsak, Ketwalee Siwapithakpong and Piyada A. Tantasawat
Vol.50 No.3 (May 2023) View: 471 Download:300
Conjugated Biopolymer-assisted the Binding of Polypropylene Toward Single-walled Carbon Nanotube:A Molecular Dynamics Simulation
page: 547 - 557
Author:Wanwisa Panman, Panupong Mahalapbutr, Oraphan Saengsawang, Chompoonut Rungnim, Nawee Kungwan, Thanyada Rungrotmongkol and Supot Hannongbua
Vol.46 No.3 (May 2019) View: 568 Download:312
page: 547 - 557
Author:Wanwisa Panman, Panupong Mahalapbutr, Oraphan Saengsawang, Chompoonut Rungnim, Nawee Kungwan, Thanyada Rungrotmongkol and Supot Hannongbua
Vol.46 No.3 (May 2019) View: 568 Download:312
Application of Polyethylene Glycol and Polymethyl
Methacrylate as a Binder for Powder Injection
Moulding of Hardmetals
page: 188 - 195
Author:Nutthita Chuankrerkkul, Peter F. Messer and Hywel A. Davies
Vol.35 No.1 (JANUARY 2008) View: 549 Download:160
page: 188 - 195
Author:Nutthita Chuankrerkkul, Peter F. Messer and Hywel A. Davies
Vol.35 No.1 (JANUARY 2008) View: 549 Download:160
Copyrights © Since 2021 All Rights Reserved by Chiang Mai Journal of Science