Synthesis and Applications of Silica Supported Dichlorotriazine (Si-DCT) in Nucleophilic Scavenging
Mookda Pattarawarapan* and Sunantanee Singhatana* Author for corresponding; e-mail address: mpatt155@yahoo.com
Volume: Vol.33 No.2 (MAY 2006)
Research Article
DOI:
Received: 29 September 2005, Revised: -, Accepted: 1 January 2006, Published: -
Citation: Pattarawarapan M. and Singhatana S., Synthesis and Applications of Silica Supported Dichlorotriazine (Si-DCT) in Nucleophilic Scavenging, Chiang Mai Journal of Science, 2006; 33(2): 203-209.
Abstract
A new method for heterogeneous nucleophilic scavenging with silica supported dichlorotriazine (Si-DCT, 2) is described. The Si-DCT was prepared by immobilized commercial grade silica gel with 3-aminopropyltrimethoxysilane, followed by reacting with cyanuric chloride. The applications of Si-DCT in removal of unwanted nucleophilic impurities from reaction mixture were demonstrated. It was shown that excess amines from sulfonamide and amide syntheses can be completely removed by adding Si-DCT and filtering off the solid. The desired products were obtained in high yields and purities without any further purification steps.