Chiang Mai Journal of Science

     Liver diseases, which encompass a wide spectrum from liver inflammation to hepatotoxicity, represent significant global health concerns due to their prevalence and severe health impacts. Extracts derived from Ganoderma species, renowned for their medicinal properties, have emerged as promising candidates for hepatoprotection. These extracts have shown efficacy in mitigating liver damage caused by various factors, such as toxins (e.g., alcohol, certain medications) and infections (e.g., hepatitis viruses). In addition, they demonstrate potential in reducing inflammatory responses within the liver and promoting its regeneration— key aspects of maintaining liver health. Furthermore, Ganoderma holds notable implications for cardiovascular health. Studies have highlighted its ability to modulate blood lipid profiles, potentially lowering cholesterol levels and reducing the risk of cardiovascular diseases. It also enhances endothelial function, which is critical for maintaining vascular health and regulating blood flow. Moreover, the anti-oxidant properties of Ganoderma help alleviate oxidative stress, a key factor implicated in cardiovascular diseases. The combination of these therapeutic attributes positions Ganoderma as a promising agent not only for managing liverrelated ailments but also for addressing cardiovascular disorders. This emphasis on the potential of Ganoderma fosters optimism about future treatments. However, comprehensive investigations are needed to fully elucidate the precise mechanisms underlying its hepatoprotective and cardiovascular effects. The potential for future discoveries in this area is substantial, and a deeper understanding of these mechanisms will be crucial for optimizing dosage regimens and unlocking the full clinical potential of Ganoderma in treating liver and cardiovascular conditions.