Tetra-n-Butyl Ammonium Iodide Catalyzed Ring Opening of Epoxides with Sodium Saccharin
Sadia Faiz, Ameer Fawad Zahoor*, Nasir Rasool, Muhammad Ajmal and Muhammad Irfan* Author for corresponding; e-mail address: fawad.zahoor@gcuf.edu.pk, fawad.zahoor@gmail.com
Volume: Vol.46 No.6 (November 2019)
Research Article
DOI:
Received: 11 May 2019, Revised: -, Accepted: 19 July 2019, Published: -
Citation: Faiz S., Zahoor A.F., Rasool N., Ajmal M. and Irfan M., Tetra-n-Butyl Ammonium Iodide Catalyzed Ring Opening of Epoxides with Sodium Saccharin, Chiang Mai Journal of Science, 2019; 46(6): 1229-1233.
Abstract
Ring opening of phenyl glycidyl ether with sodium saccharin has been investigated and the methodology has been developed successfully. The product has been obtained via ring opening of the epoxide by the attack of the sodium saccharin at the less substituted carbon (SN2-type mechanism). We have also proposed a potential route to access 1,2-benzothiazine/ isoquinolines derivatives over a few steps.