One-pot Three Components Synthesis of 3-(α-arylaminobenzylidene)indoles Catalysed by L-proline
Tahira Naqvi, Masood Ahmad Rizvi and Kamal K. Kapoor* Author for corresponding; e-mail address: k2kapoor@yahoo.com; masoodku2@gmail.com
Volume: Vol.42 No.4 (OCTOBER 2015)
Research Article
DOI:
Received: 30 April 2014, Revised: -, Accepted: 28 October 2014, Published: -
Citation: Naqvi T., Rizvi M.A. and Kapoor K.K., One-pot Three Components Synthesis of 3-(α-arylaminobenzylidene)indoles Catalysed by L-proline , Chiang Mai Journal of Science, 2015; 42(4): 877-885.
Abstract
The one-pot three-components synthesis of 3-(α-arylaminobenzyl)indoles is achieved from indole, aromatic aldehydes and anilines by using L-proline as a catalyst. The reaction produced 3-alkyl-indoles in dominance over the bisindolyl alkanes. The reported L-proline catalyzed synthetic methodology is an environmentally benign alternative for the synthesis of 3-alkyl-indoles with comparable catalytic efficiency to that of costly and toxic metal based catalysts.