Chiang Mai Journal of Science

 A total of 108 isolates of endophytic fungi were isolated from the medicinal plant Artemisia argyi. The anti-tumor and anti-microbial bioactivities of the fermentation extracts (FEs) of each isolate were evaluated via different assay methods. Seventeen strains were found to produce bioactive components and identified via ITS rDNA sequence data. The results showed that the Fes from five (4.6 %) of the isolates exhibited anti-tumor activity and fifteen (13.9 %) of the isolates exhibitedanti-microbial activity. The phylogenetic tree based on ITS rDNA sequence identified these bioactive isolates into 10 genera in Ascomycetes, and 1 in Basidiomycetes. The main representative group namely Pleosporales had 4 isolates (23.5 %) along with three Alternaria spp. The results indicate that the endophytic fungi from A. argyi are promising novel source for bioactive compounds.