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Formulation and Physicochemical Properties of Nanostructured Lipid Carriers from Beeswax and Rosemary oil as a Drug Carrier
Paper Type  |
Contributed Paper |
Title |
Formulation and Physicochemical Properties of Nanostructured Lipid Carriers from Beeswax and Rosemary oil as a Drug Carrier |
Author |
Farhanim Mohd Latif, Yin Yin Teo, Misni Misran, Vicit Rizal Eh Suk and Kah Hin Low |
Email |
yinyinteo@um.edu.my |
|
Abstract: The toxicity and insolubility of drugs in water remain a significant problem and has led to
the development of food-grade drug delivery systems such as nanostructured lipid carriers (NLCs). A
stable colloidal suspension of NLCs was prepared from a natural source of lipids. NLCs composed of
beeswax (BW), rosemary oil (RO), and poloxamer 188 (P188) were prepared using melt-emulsification
combined with ultrasonication. The optimised formulation with the smallest particle size and highest
magnitude of zeta potential was selected for loading with terbinafine hydrochloride (TBHCl). TBHCl
is a synthetic allylamine drug that functions as an antifungal. The optimised formulation comprised
3.75 % BW, 1.25 % RO, 3 % P188, and 92 % deionised water (DW). The mean particle size and zeta
potential of the optimised NLCs was 174 ± 2 nm and -36 ± 5 mV, respectively. The morphology of
the NLCs was observed as spherical with a dense appearance in the TEM images. The encapsulation
and loading efficiencies were found to be dependent on the amount of TBHCl. The release of TBHCl
from the optimised formulation was 62.87 ± 0.04 % during the 48-hour analysis. |
|
Start & End Page |
114 - 126 |
Received Date |
2019-06-17 |
Revised Date |
|
Accepted Date |
2019-08-25 |
Full Text |
Download |
Keyword |
colloidal, lipid, beeswax, rosemary oil, nanostructured lipid carriers |
Volume |
Vol.47 No.1 (January 2020) |
DOI |
|
Citation |
Latif F.M., Teo Y.Y., Misran M., Suk V.R.E. and Low K.H., Formulation and Physicochemical Properties of Nanostructured Lipid Carriers from Beeswax and Rosemary oil as a Drug Carrier, Chiang Mai Journal of Science, 2020; 47(1): 114-126. |
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