Chiang Mai Journal of Science, Faculty of Science, Chiang Mai University

1.0

2023CiteScore

33rd percentile

Journal Volumes

Visitors
ALL : 2,316,655
TODAY : 9,955
ONLINE : 1,031

Submit your paper

Download Template

JOURNAL DETAIL

Formulation and Physicochemical Properties of Nanostructured Lipid Carriers from Beeswax and Rosemary oil as a Drug Carrier

Paper Type	Contributed Paper
Title	Formulation and Physicochemical Properties of Nanostructured Lipid Carriers from Beeswax and Rosemary oil as a Drug Carrier
Author	Farhanim Mohd Latif, Yin Yin Teo, Misni Misran, Vicit Rizal Eh Suk and Kah Hin Low
Email	yinyinteo@um.edu.my
Abstract: The toxicity and insolubility of drugs in water remain a significant problem and has led to the development of food-grade drug delivery systems such as nanostructured lipid carriers (NLCs). A stable colloidal suspension of NLCs was prepared from a natural source of lipids. NLCs composed of beeswax (BW), rosemary oil (RO), and poloxamer 188 (P188) were prepared using melt-emulsification combined with ultrasonication. The optimised formulation with the smallest particle size and highest magnitude of zeta potential was selected for loading with terbinafine hydrochloride (TBHCl). TBHCl is a synthetic allylamine drug that functions as an antifungal. The optimised formulation comprised 3.75 % BW, 1.25 % RO, 3 % P188, and 92 % deionised water (DW). The mean particle size and zeta potential of the optimised NLCs was 174 ± 2 nm and -36 ± 5 mV, respectively. The morphology of the NLCs was observed as spherical with a dense appearance in the TEM images. The encapsulation and loading efficiencies were found to be dependent on the amount of TBHCl. The release of TBHCl from the optimised formulation was 62.87 ± 0.04 % during the 48-hour analysis.
Start & End Page	114 - 126
Received Date	2019-06-17
Revised Date
Accepted Date	2019-08-25
Full Text	Download
Keyword	colloidal, lipid, beeswax, rosemary oil, nanostructured lipid carriers
Volume	Vol.47 No.1 (January 2020)
DOI
Citation	Latif F.M., Teo Y.Y., Misran M., Suk V.R.E. and Low K.H., Formulation and Physicochemical Properties of Nanostructured Lipid Carriers from Beeswax and Rosemary oil as a Drug Carrier, Chiang Mai J. Sci., 2020; 47(1): 114-126.
SDGs
View:652 Download:428

Carbohydrate and Lipid Metabolism Characteristics of Hypoxia Tolerance in Gastrocnemius of the Gansu zokor, Eospalax cansus
page: 348 - 363
Author:Jinyan Lin, Li Zhao, Nannan Lin, Qi Yang, Zhiqiang Hao, Xiaoqi Sun, Jianping He and Jingang Li
Vol.49 No.2 (March 2022) View: 689 Download:291

Phytochemical Investigation and Antioxidant Properties of Different Extracts from Artabotrys harmandii Finet & Gagnep
page: 2338 - 2347
Author:Wararut Bunchareon, Supaporn Pamok, Supap Saenphet and Kanokporn Saenphet
Vol.45 No.6 (September 2018) View: 666 Download:331

Investigation of Anti-obesity and Anti-hyperlipidemic Activities of Morinda citrifolia Fruits in Rat Model
page: 1335 - 1344
Author:Hooi-Kheng Beh*, Zhari Ismail, Lay-Jing Seow, Mohd Zaini Asmawi, Pazilah Ibrahim, Vikneswaran Murugaiyah, Eng-Keng Seow and Khalid Hussain
Vol.45 No.3 (May 2018) View: 619 Download:200

In vitro Antioxidant Evaluation of Wood Vinegars from Carbonization of Wood and Bamboo
page: 868 - 880
Author:Yongyuth Theapparat*, Chanita Ponglimanont, Ausa Chandumpai and Nikhom Laemsak
Vol.45 No.2 (March 2018) View: 624 Download:277

Total Phenolic and Ascorbic Acid Contents and Antioxidant Activities of Twelve Different Ecotypes of Phyllanthus emblica from Pakistan
page: 904 - 911
Author:Syed Mubashar Sabir*, Rashad Hussain Shah and Asad Hussain Shah
Vol.44 No.3 (July 2017) View: 598 Download:235

Thermally Oxidized Olive Oil Produces Biochemical, Physiological Effects and Fatty Liver in Rats
page: 847 - 857
Author:Ayaz Ali Khan, Alam Zeb* and Syed Tufail Hussain Shirazi
Vol.44 No.3 (July 2017) View: 566 Download:208

Lipid Peroxidation of Escherichia coli by Triplet Non-thermal Atmospheric Pressure Plasma Jet
page: 678 - 687
Author:A. Hossienzadeh Colagar* [a,b], O. Alavi [a], F. Sohbatzadeh [b, c]
Vol.44 No.2 (April 2017) View: 604 Download:169

Properties and Colloidal Behavior of Casting Slip Containing Ratchaburi Red Clay
page: 660 - 666
Author:Anucha Wannagon*, Watcharee Sornlar and Pattarawan Choeycharoen
Vol.44 No.2 (April 2017) View: 565 Download:650

Catalytic Oxidation of Glucose with Hydrogen Peroxide and Colloidal Gold as Pseudo-Homogenous Catalyst: A Combined Experimental and Theoretical Investigation
page: 825 - 833
Author:Jitrayut Jitonnom [a] and Christoph Sontag *[a]
Vol.43 No.4 (JULY 2016) View: 606 Download:418

Ameliorating Reactive Oxygen Species-Induced in vitro Lipid Peroxidation in Liver, Carbohydrate and DNA Damage by Dendrocalamus hamiltonii Different Leaf Extracts
page: 80 - 88
Author:Arvind Kumar Goyal [a,b], Sushil Kumar Middha [c], Talambedu Usha [c] and Arnab Sen*[a]
Vol.43 No.1 (JANUARY 2016) View: 623 Download:143

Fatty Acid Composition, Physical Properties, Acute Oral Toxicity and Antioxidant Activity of Crude Lipids from Adipose Tissue of Some Commercialized Freshwater Catfish
page: 626 - 636
Author:Wiwat Wangcharoen, Kriangsak Mengumphan and Doungporn Amornlerdpison
Vol.42 No.3 (JULY 2015) View: 582 Download:162

Selection of some native microalgal strains for possibility of bio – oil production in Thailand
page: 593 - 602
Author:Krongkan Janta, Jeeraporn Pekkoh, Sudaporn Tongsiri, Chayakorn Pumas and Yuwadee Peerapornpisal
Vol.40 No.4 (OCTOBER 2013) View: 573 Download:190

Antioxidant Potential of Pleurotus porrigens Extract and Application in Sunflower Oil during Accelerated Storage
page: 34 - 48
Author:Hip Seng Yim*[a, b], Fook Yee Chye [b], Mei Lian Liow [a], and Chun Wai Ho [a]
Vol.40 No.1 (JANUARY 2013) View: 615 Download:206

In vitro INHIBITION OF LIPID PEROXIDATION AND THE ANTIOXIDANT SYSTEM OF ENDOPHYTIC FUNGI FROM THAI MEDICINAL PLANTS
page: 429 - 444
Author:Teerayut Theantana [a,b], Duangta Kanjanapothi [c], Saisamorn Lumyong* [b]
Vol.39 No.3 (JULY 2012) View: 608 Download:171

Comparative Analysis of Aqueous Extracts of Amaranth and Coriander in Scavenging Free Radical Activity and Protection of DNA against Oxidative Damage
page: 560 - 571
Author:Asmita Dutta and Mukesh Singh
Vol.38 No.4 (OCTOBER 2011) View: 604 Download:259

A Smart Hydrogel-Based System for Controlled Drug Release
page: 471 - 478
Author:Patchara Punyamoonwongsa * and Brian J. Tighe
Vol.32 No.3 (SEPTEMBER 2005) View: 593 Download:182

Search in this journal

Document Search

Author Search

A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z

Chiang Mai Journal of Science

Journal Volumes

JOURNAL DETAIL

Formulation and Physicochemical Properties of Nanostructured Lipid Carriers from Beeswax and Rosemary oil as a Drug Carrier

RELATED ARTICLE

Search in this journal

Popular Search

Chiang Mai Journal of Science