Chiang Mai Journal of Science

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The research was primarily to test the toxicity of antifertility plant extracts eg. aqueous and ethanolic extract of Pueraria mirifica, chloroform extract of Sida rhombifolia and methanolic extract of Aegle marmelos on mice by micronucleus test. The results showed that the ethanolic extract of P. mirifica (0.33 g/Kg.BW ) treated to rats for 7 and 14 days was significantly effective in inducing the formation of micronucleus in polychromatic erythrocytes (P<0.05) whereas aqueous extract of the same plant did not give the appreciable result. Chloroform extract of S. rhombifolia (1.6 g/Kg.BW ) was also able to induce micronucleus formation in a markedly high frequency as compared to controls (P< 0.05). Nevertheless, extracts of both P. mirifica and S. rhombifolia, were less effective to induce micronucleus formation than cyclophosphamide, a genuine mutagenic agent (P<0.01).Methanolic extract of A. marmelos at all doses used (1.6 and 3.2 g/Kg.BW) had no effect on the induction of micronuclei in polychromatic erythrocytes.

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