Chiang Mai Journal of Science

A  three-component  Mannich-type  reaction  of  aromatic  aldehydes, aromatic  amines, and ketones  was  catalyzed  by  a  novel  task-specific  ionic  liquid, 4-(3-sulfopropyl) morpholinium  hydrogen  sulfate ([C₃SO₃Hnhm]HSO₄)  at  room  temperature  to  give  various  β-amino  carbonyl  compounds  in  good  yields. The  products  could  simply  be  separated  from  catalyst/ethanol, and the  catalytic  system  could  be  recycled  and reused  for  six  times  without  noticeably  decreasing  catalytic  activity.