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Anti-aging Cosmeceutical Product Containing of Nymphaea rubra Roxb. ex Andrews extract
Paper Type  |
Contributed Paper |
Title |
Anti-aging Cosmeceutical Product Containing of Nymphaea rubra Roxb. ex Andrews extract |
Author |
Marisa Kamma, Wei Chao Lin, Shang-Chian Lau Sunee Chansakaow and Pimporn Leelapornpisid* |
Email |
pim_leela@hotmail.com |
|
Abstract: The objectives of this study were to examine the biological activities of petal extract (PE) and
stamen extract (SE) from Nymphaea rubra Roxb. ex Andrews, develop the extracts into a cosmeceutical
product and evaluate the skin irritation as well as test the performance of the emulsion containing N. rubra
extract. The petal and stamen extracts of N. rubra were conducted with 95% ethanol. The antioxidant
activity, tyrosinase activities and total phenolic and flavonoid content of the extracts were determined.
The anti-aging capability of the extracts were also tested by the inhibition of MMP-2, MMP-9 and
hyaluronidase activities. The PE showed the highest antioxidant activity on lipid peroxidation inhibition
and inhibition of tyrosinase activity together with the highest amount of total phenolic and flavonoid
contents. Both the PE and SE showed high ability as antioxidants tested by DPPH and ABTS assays,
which are comparable to ascorbic acid and trolox. Furthermore, they strongly inhibited MMP-2 and
MMP-9, while the PE showed the highest in vitro hyaluronidase inhibition. The PE was then selected
for incorporation into O/W emulsion, and the PE emulsion was stable under various tested conditions.
According to the clinical evaluation, the PE emulsion was effective on skin wrinkle reduction and skin
whitening with no irritation in 30 healthy volunteers after 60 days of twice daily application. Thus, the petal
extract and PE emulsion possess potential anti-free radical, skin lightening and anti-aging properties.
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Start & End Page |
1143 - 1160 |
Received Date |
2019-06-17 |
Revised Date |
|
Accepted Date |
2019-08-25 |
Full Text |
Download |
Keyword |
Nymphaea rubra Roxb. ex Andrews, anti-aging, biological activities, cosmeceutical |
Volume |
Vol.46 No.6 (November 2019) |
DOI |
|
Citation |
Kamma M., Lin W.C., Chansakaow S.L.S. and Leelapornpisid* P., Anti-aging Cosmeceutical Product Containing of Nymphaea rubra Roxb. ex Andrews extract, Chiang Mai Journal of Science, 2019; 46(6): 1143-1160. |
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