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Helvolic Acid, A Secondary Metabolite Produced by Neosartorya spinosa KKU-1NK1 and Its Biological Activities
Paper Type  |
Contributed Paper |
Title |
Helvolic Acid, A Secondary Metabolite Produced by Neosartorya spinosa KKU-1NK1 and Its Biological Activities |
Author |
Wareerat Sanmanoch [a], Wiyada Mongkolthanaruk [a], Somdej Kanokmedhakul [b], Tadanori Aimi [c] and Sophon Boonlue *[a, b] |
Email |
bsopho@kku.ac.th |
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Abstract: Helvolic acid, an antimicrobial metabolite was isolated from the crude ethyl acetate extract of the soil fungus [A1] Neosartorya spinosa KKU-1NK1. The isolated helvolic acid inhibited growth of[A2] Gram positive [A3] pathogenic bacteria (Methicillin-resistant Staphylococcus aureus DMST 20654, Staphylococcus aureus ATCC 25923, Staphylococcus saprophyticus ATCC 15305, Streptococcus pneumonia DMST 15319, Enterococus faecalis ATCC 29212 and Bacillus subtilis ATCC 6633) and Gram negative [A4] plant pathogenic bacteria (Ralstonia solanacearum, Xanthomonas campestris pv. vesicatoria) with the MIC ranging from 16-32 µg/ml. It also showed an unprecedented antimicrobial activity against Mycobacterium tuberculosis H37Ra strain with the MIC ranging from 12.5-25.0 [KKU5] µg/ml. In addition, the result of time kill assay revealed that helvolic acid was bacteriostatic, which inhibited the growth of pathogenic bacteria at 2 fold of MIC. As a result of irregular-shaped cell division was observed by scanning electron microscopy.
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Start & End Page |
484 - 494 |
Received Date |
2015-06-17 |
Revised Date |
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Accepted Date |
2015-10-27 |
Full Text |
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Keyword |
Antibacterial metabolite, Antimycobacterium, Bacteriostatic, Helvolic acid, Neosartorya sp. |
Volume |
Vol.43 No.3 (APRIL 2016) |
DOI |
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Citation |
[a] W.S., [a] W.M., [b] S.K., [c] T.A., *[a S.B. and B] , Helvolic Acid, A Secondary Metabolite Produced by Neosartorya spinosa KKU-1NK1 and Its Biological Activities, Chiang Mai Journal of Science, 2016; 43(3): 484-494. |
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