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Synthesis of N-([1,1'-biphenyl]-4-ylmethyl)-4- methylpyridin-2-amines and Antibacterial Evaluation: Agar Well Diffusion Method, Docking Studies and DFT Insights


Paper Type 
Contributed Paper
Title 
Synthesis of N-([1,1'-biphenyl]-4-ylmethyl)-4- methylpyridin-2-amines and Antibacterial Evaluation: Agar Well Diffusion Method, Docking Studies and DFT Insights
Author 
Numan Sajid, Shehla Khalid, Abid Mahmood, Muhammad Usman Qamar, Nasir Rasool, Muhammad Imran ,Cezario Petru Podasca and Catalin Misarca
Email 
nasirrasool@gcuf.edu.pk, caesarpodaska@yahoo.com
Abstract:

     The pharmaceutical sector is facing major concerns in addressing effective drug molecules against extensively drug-resistant S. Typhi. Exploiting the medicinal benefits of amines, we synthesized novel small organic molecules bearing both pyridine and secondary amine linkages. The N-(4-bromobenzyl)-4-methylpyridin-2-amine (3) and derivatives (5a–c) have been synthesized which are effective against multiple drugresistant S. Typhi. Then, the antibacterial efficacy of these compounds was determined by using Agar Well diffusion assay (AWDA). Compound 5b was active (MIC 3.125 mg/mL). Molecular docking studies demonstrated the behavior of small molecules at the binding sites of XDR-S. Typhi 5ZTJ protein through atomic-level interaction. Moreover, the structure elucidation, evaluation of optimized geometry, and molecular stability were done via DFT analysis.

Graphical Abstract:
Article ID
e2025023
Received Date 
2024-11-27
Revised Date 
2025-02-11
Accepted Date 
2025-03-11
Published Date 
2025-05-15
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Keyword 
pyridine-2-amine, XDR S. Typhi, drug resistance, docking studies, DFT
Volume 
Vol.52 No.3 (May 2025)
DOI 
https://doi.org/10.12982/CMJS.2025.023
Citation 
Sajid N.,Khalid S.,Mahmood A.,Qamar M.,U.,Rasool N.,Imran M., et al., Synthesis of N-([1,1'-biphenyl]-4-ylmethyl)-4- methylpyridin-2-amines and Antibacterial Evaluation: Agar Well Diffusion Method, Docking Studies and DFT Insights, Chiang Mai Journal of Science, 2025; 52(3): e2025023. DOI 10.12982/CMJS.2025.023.
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